Metabolism

Metabolic parameters can be measured reliably—accordingly, the studies are robust, and the question of whether an altered laboratory value also has clinical significance is all the more important.

1. Which Substances Were Investigated for This Purpose

The overview shows how many studies exist per substance and type of investigation. A single study may be assigned to multiple topics—therefore, the numbers cannot be added together but instead describe this specific subset.

2. All Substances and Therapies with Controlled Studies on Metabolism

104 substance and therapy pages assign controlled human studies to this area. The number comes from each page; one study can belong to several areas.

3. The Most Robust Studies

Ranked by evidential strength, not by familiarity.

Controlled Human Study

• 1 The Essential Medicinal Chemistry of Curcumin (2017)
• 2 Vitamin D for the Prevention of Disease: An Endocrine Society Clinical Practice Guideline (2024)
• 3 Antioxidant and anti-inflammatory effects of curcuminoid-piperine combination in subjects with metabolic syndrome: A randomized controlled trial and an (2015)
• 4 Can supplementation with vitamin D reduce the risk or modify the course of autoimmune diseases? A systematic review of the literature (2012)
• 5 Effects of phytosomal curcumin on anthropometric parameters, insulin resistance, cortisolemia and non-alcoholic fatty liver disease indices: a double- (2020)
• 6 Nano-curcumin improves glucose indices, lipids, inflammation, and Nesfatin in overweight and obese patients with non-alcoholic fatty liver disease (NAFLD): A (2019)
• 7 Enriched Marine Oil Supplements Increase Peripheral Blood Specialized Pro-Resolving Mediators Concentrations and Reprogram Host Immune Responses: A Ra (2020)
• 8 Phytosome complex of curcumin as complementary therapy of advanced pancreatic cancer improves safety and efficacy of gemcitabine: Results of a prospec (2018)
• 9 Dietary Supplementation with Curcumin Reduce Circulating Levels of Glycogen Synthase Kinase-3β and Islet Amyloid Polypeptide in Adults with High Risk of Type 2 Diabetes (2020)
• 10 Curcumin and/or omega-3 polyunsaturated fatty acids supplementation reduces insulin resistance and blood lipids in individuals with high risk of type 2 diabetes (2019)
• 11 Anti-Inflammatory Diet Prevents Subclinical Colonic Inflammation and Alters Metabolomic Profile of Ulcerative Colitis Patients in Clinical Remission (2022)
• 12 Curcumin Supplementation and Human Disease: A Scoping Review of Clinical Trials (2023)
• 13 Safety and clinical effectiveness of Withania Somnifera (Linn.) Dunal root in human ailments (2020)
• 14 Highly bioavailable micellar curcuminoids accumulate in the blood, are safe, and do not reduce blood lipids or inflammation markers in moderate hyperlipidaemia (2016)
• 15 Further evidence of benefits to mood and working memory from lipidated curcumin in healthy older adults: A 12-week, double-blind, placebo-controlled trial (2020)
• 16 A narrative review of the evidence for variations in serum 25-hydroxyvitamin D concentration thresholds for optimal health (2022)
• 17 Ergocalciferol and microcirculatory function in chronic kidney disease with concomitant vitamin D deficiency: An exploratory, double-blind, randomised trial (2014)
• 18 Stimulating the resolution of inflammation through omega-3 polyunsaturated fatty acids in COVID-19: Rationale for the COVID-Omega-F trial (2020)
• 19 Colloidal submicron-particle curcumin demonstrates high absorption efficiency: A double-blind, three-way crossover study (2015)
• 20 Effects of Rhodiola rosea supplementation on mental performance, physical capacity, and oxidative stress biomarkers in healthy men (2018)