Knowledge · Natural Compounds

Green Tea and EGCG

Q: Does Green Tea and EGCG help with body weight and metabolism? What the studies show

We evaluated 18 meta-analyses or systematic reviews, 25 controlled studies and 13 further studies; the controlled studies include 900 participants in total. Result of the controlled studies: mixed. Strength of evidence under our published rules: high. Sources: [1, 5, 7, 8]

Q: Does Green Tea and EGCG help with heart and circulation? What the studies show

We evaluated 13 meta-analyses or systematic reviews, 22 controlled studies and 12 further studies; the controlled studies include 1,114 participants in total. Result of the controlled studies: mostly improved. Strength of evidence under our published rules: high. Sources: [2, 3, 6, 9]

Q: Does Green Tea and EGCG help with teeth and oral cavity? What the studies show

We evaluated 2 meta-analyses or systematic reviews, 18 controlled studies and one further study; the controlled studies include 716 participants in total. Result of the controlled studies: mostly improved. Strength of evidence under our published rules: high. Sources: [14, 26, 44, 95]

Q: Does Green Tea and EGCG help with skin? What the studies show

We evaluated one meta-analysis or systematic review, 5 controlled studies and 4 further studies; the controlled studies include 239 participants in total. Result of the controlled studies: mixed. Strength of evidence under our published rules: high. Sources: [20, 33, 34, 103]

Q: Does Green Tea and EGCG help with cancer? What the studies show

We evaluated 2 meta-analyses or systematic reviews, 5 controlled studies and 13 further studies; the controlled studies include 1,371 participants in total. Result of the controlled studies: mostly no difference. Strength of evidence under our published rules: moderate. Sources: [11, 19, 49, 55]

Q: Does Green Tea and EGCG help with liver? What the studies show

We evaluated one meta-analysis or systematic review, 4 controlled studies and 5 further studies; the controlled studies include 1,199 participants in total. Result of the controlled studies: mostly no difference. Strength of evidence under our published rules: moderate. Sources: [7, 15, 46, 64]

Q: Does green tea help with weight loss?

Meta-analyses found only a slight decrease in body weight, BMI and body fat percentage with green tea extract [5, 37]; drinks with added catechins reduced abdominal fat [13, 85]. One meta-analysis found no weight difference outside Japan, and a decaffeinated catechin extract did not change weight over one year [59, 91].

Q: Does green tea lower blood sugar?

Meta-analyses found slightly lower fasting blood sugar and HbA1c values with green tea, green tea extract or EGCG [17, 38, 45]. An overview of meta-analyses and a meta-analysis in metabolic syndrome, by contrast, found no difference [30, 47]. The findings come predominantly from short to medium-term studies.

Q: Does green tea help against caries and gum inflammation?

Mouth rinses, dental floss and chewing gum with green tea extract reduced dental plaque and gum bleeding [110, 121]; in periodontitis, locally applied green tea extract or EGCG reduced gum pocket depth [14, 149, 173].

Green tea and green tea extract slightly lowered cholesterol, blood pressure and weight, mouth rinses reduced dental plaque; for cancer, no confirmed benefit was shown, and high-dose extracts can stress the liver.

Last updated: 2026-10-15

We evaluated 265 human studies on Green Tea and EGCG, including 156 randomised controlled trials and 61 meta-analyses or systematic reviews; the controlled studies include 12,147 participants in total. As of 5 October 2026.

This page as PDF · Summary

1. What Is Green Tea and EGCG? Occurrence, Origin and Forms

Green tea is an infusion of the leaves of the tea plant Camellia sinensis, which are barely oxidised after harvesting. EGCG (epigallocatechin gallate) is the most abundant catechin in green tea and belongs to the polyphenol group. Traditionally, green tea is drunk as an everyday beverage in East Asia; studies examine both the beverage and extracts made from it.

The leaves of Camellia sinensis provide the infusion; extracts are obtained from them and used in capsules, powders or beverages. The plant is cultivated mainly in East Asia and other subtropical regions.

For green tea, the leaf is briefly heated or steamed after harvesting and then dried, which largely prevents oxidation. For extracts, the leaves are leached with water or solvents and the result is dried; studies examine the infusion, the extract and individual catechins such as EGCG.

Forms and Preparations Studied

Infusion of the leaves (beverage)
Green tea extract in capsules or tablets
Decaffeinated green tea or extract
EGCG-enriched extract
Ground leaf powder (for stirring in)

Not covered on this page:

Black tea and oolong tea, in which the leaf is oxidised more strongly
Herbal and fruit teas from other plant species
Other catechins and polyphenols from sources other than Camellia sinensis

2. What Does Green Tea and EGCG Do? Results by Area

Area	Result in controlled studies	Strength of evidence	Studies	Participants
Body weight and metabolism	mixed	high	18 meta-analyses · 25 controlled · 13 other	900
Heart and circulation	mostly improved	high	13 meta-analyses · 22 controlled · 12 other	1,114
Teeth and oral cavity	mostly improved	high	2 meta-analyses · 18 controlled · 1 other	716
Skin	mixed	high	1 meta-analyses · 5 controlled · 4 other	239
Cancer	mostly no difference	moderate	2 meta-analyses · 5 controlled · 13 other	1,371
Liver	mostly no difference	moderate	1 meta-analyses · 4 controlled · 5 other	1,199
Other investigations	mostly improved	high	9 meta-analyses · 72 controlled · 38 other	4,697

How to read the table: counted are human studies whose results concern the area. “High” means at least one meta-analysis and two controlled studies showing improvement, or at least three controlled studies of which three quarters show improvement, with at least 300 participants in total. “Moderate” means at least two controlled studies showing improvement, as a majority, or one meta-analysis alongside controlled studies. “Low” means one controlled study showing improvement. Where an area has no controlled study, the strength of evidence is at most “low” (result “reviews only” or “observational data only”). Everything else is “unclear”. A study counts as showing improvement when at least half of its outcomes in this area improved. Reviews of combination products do not count as meta-analyses; results that only describe side effects or shares of users do not count as an effect. The same study is counted only once.

3. What the Studies Show in Detail

Green Tea and EGCG, Body Weight and Metabolism: Human Studies

In overweight, according to meta-analyses, green tea extract slightly lowered body weight, BMI and body fat percentage 5 37. Drinks with added tea catechins reduced abdominal fat, including visceral fat, compared with placebo drinks 13 85. In girls with obesity, a decaffeinated polyphenol extract lowered body fat percentage more than placebo 109. In addition to exercise, according to a meta-analysis, green tea brought only little additional weight loss 43. One meta-analysis found no weight difference outside Japan 59. Studies from Japan showed small advantages that the authors consider hardly clinically meaningful 59. A decaffeinated catechin extract did not change weight over one year 91. Meta-analyses found somewhat lower fasting blood sugar and HbA1c values with green tea, green tea extract and EGCG, but only a small effect for HbA1c 17 38 45. Three cups of green tea daily lowered HbA1c and total cholesterol in type 2 diabetes with kidney damage compared with a group without tea 104. An overview of meta-analyses and a meta-analysis in metabolic syndrome, by contrast, found no difference 30 47.

Study	Design · participants	Preparation · dose · duration · comparison	Result
1 Wang et al. 2025	systematic review · 30,133 participants	Dietary supplements, including green tea catechins; vs. Placebo or control in 46 randomized trials	Adiposity: improved
5 Asbaghi et al. 2024	meta-analysis · 3,802 participants	green tea extract (GTE) as dietary supplement; vs. placebo or control	body mass (BM): improved (significantly reduced); body fat percentage (BFP): improved (significantly reduced); BMI: improved (significantly reduced)
7 Ranneh et al. 2024	systematic review · 1,840 participants	Polyphenol dietary supplementation, including green tea extract; vs. various polyphenol supplements versus control or each other	lipid profile: improved
8 Jayedi et al. 2024	meta-analysis · 1,710 participants	Green tea (beverage), compared with coffee, black tea, sour tea; average 10 weeks; vs. placebo, water, other beverages	weight loss versus placebo: improved (MD: −1·23 kg, 95 % CrI: −2·45, −0·02); weight loss versus water: improved (MD: −1·61 kg, 95 % CrI: −2·90, −0·35); weight loss versus water (healthy individuals): improved (MD: −3·31 kg, 95 % CrI: −5·83, −1·04)
12 Zago et al. 2026	meta-analysis · 1,109 participants	Green tea / green tea extract; vs. Placebo	Weight, BMI, body composition, blood glucose: no difference
13 Hibi et al. 2018	meta-analysis · 921 participants	Green tea catechin (GTC)-containing beverages; 540-588 mg GTC per beverage; 12 weeks; vs. Placebo beverage	Total fat area: improved (-17.7cm2, 95%CI: -20.9 to -14.4); Visceral fat area: improved (-7.5cm2, 95%CI: -9.3 to -5.7); Subcutaneous fat area: improved (-10.2cm2, 95%CI: -12.5 to -7.8)
17 Jia et al. 2024	meta-analysis · 722 participants	Green tea (form not specified); vs. Control group	Fasting blood glucose: improved (SMD = -0.41, 95% CI: -0.67 to -0.19, P = .001); Glycated hemoglobin: improved (SMD = -0.68, 95% CI: -1.15 to 0.21, P = .004); Insulin resistance index: improved (SMD = -0.70, 95% CI: -1.18 to -0.22, P = .005)
18 Wang et al. 2023	meta-analysis · 613 participants	green tea catechin supplement (extract); vs. control group (placebo) in 11 RCTs	waist circumference: improved (pooled WMD = -1.37 cm, 95 % CI: -2.52 to -0.22 cm, p = 0.019); triglyceride: improved (pooled WMD = -0.18 mmol/L, 95 % CI: -0.35 to -0.02 mmol/L, p = 0.032); HDL cholesterol: improved (pooled WMD = 0.07 mmol/L, 95 % CI: 0.01-0.14 mmol/L, p = 0.031)

Further studies in this area: 21 23 30 37 38 39 43 45 46 47 53 57 59 63 78 85 91 104 109 115 120 126 132 137 140 142 151 155 156 157 158 159 160 167 171 174 175 184 189 205 211 213 215 222 223 224 231 232

Green Tea and EGCG, Heart and Circulation: Human Studies

Meta-analyses found somewhat lower total and LDL cholesterol with green tea and green tea catechins than in the control groups 6 10 45 57. Two types of green tea extract powder lowered LDL cholesterol more than placebo 78. For HDL cholesterol and triglycerides, the results were inconsistent 6 10 18 50. Meta-analyses also found a slight lowering of blood pressure by about one to two mmHg 9 29 57. In overweight, metabolic syndrome and in a one-year extract study, by contrast, no difference was shown 18 30 67. With green tea extract, HDL cholesterol fell in two studies, in one of them in addition to brisk walking 145 184.

Study	Design · participants	Preparation · dose · duration · comparison	Result
2 Osadnik et al. 2022	meta-analysis · 13,062 participants	Green tea extract compared with other nutraceuticals; vs. Placebo/no intervention and other nutraceuticals	LDL cholesterol: improved (-1.21 [-46.8 mg/dL] to -0.17 [-6.6 mg/dL] mmol/l reduction); Total cholesterol: improved (-1.75 [-67.7 mg/dL] to -0.18 [7 mg/dL] mmol/l reduction)
3 Lagou et al. 2025	meta-analysis · 5,205 participants	Flavan-3-ol-rich foods, beverages or supplements (incl. EGCG, tea, cocoa); 586 mg total flavan-3-ols (95% CI 510, 662); chronic repetitive consumption, duration not reported; vs. control (placebo/no intervention)	office blood pressure systolic/diastolic: improved (-2.8 [95% CI -3.9, -1.7]/-2.0 [-2.6, -1.3] mmHg); 24 h-ambulatory blood pressure systolic/diastolic: improved (-3.7 [-5.8, -1.6]/-2.6 [-4.5, -0.8] mmHg); flow-mediated dilation after acute consumption: improved (+2.0% [1.6, 2.3])
6 Xu et al. 2020	meta-analysis · 3,321 participants	Green tea consumption (preparation form not specified); vs. Green tea supplementation versus control group	Total cholesterol: improved (WMD: - 4.66 mg/dL; 95% CI: - 6.36, - 2.96 mg/dL; P < 0.0001); LDL cholesterol: improved (WMD:- 4.55 mg/dL; 95% CI: - 6.31, - 2.80 mg/dL; P < 0.0001); HDL cholesterol: no difference
9 Xu et al. 2020	meta-analysis · 1,697 participants	Green tea supplementation (form not specified); short-term trials; vs. Placebo	Systolic blood pressure: improved (MD: -1.17 mm Hg; 95%CI: -2.18 to -0.16mm Hg; P = .02); Diastolic blood pressure: improved (MD: -1.24 mm Hg; 95%CI:-2.07 to -0.40mm Hg; P = .004)
10 Kim et al. 2011	meta-analysis · 1,415 participants	Green tea catechins (GTCs); 145 to 3,000 mg/day; 3 to 24 weeks; vs. Control	Total cholesterol: improved (-5.46 mg/dL [-0.14 mmol/L]; 95% CI -9.59 to -1.32); LDL cholesterol: improved (-5.30 mg/dL [-0.14 mmol/L]; 95% CI -9.99 to -0.62); HDL cholesterol: no difference (-0.27 mg/dL [-0.007 mmol/L]; 95% CI -1.62 to 1.09)
12 Zago et al. 2026	meta-analysis · 1,109 participants	Green tea / green tea extract; vs. Placebo	Total cholesterol: improved (MD: -7.03; 95% CI: -13.24 to -0.82; p = 0.03; I² = 0%); Lipid profile (other than total cholesterol): no difference
13 Hibi et al. 2018	meta-analysis · 921 participants	Green tea catechin (GTC)-containing beverages; 540-588 mg GTC per beverage; 12 weeks; vs. Placebo beverage	Blood pressure: improved
18 Wang et al. 2023	meta-analysis · 613 participants	green tea catechin supplement (extract); vs. control group (placebo) in 11 RCTs	blood pressure: no difference

Further studies in this area: 22 28 29 30 39 43 45 50 56 57 67 78 99 104 112 126 137 138 142 145 150 151 152 154 157 160 171 177 180 184 187 189 195 200 208 215 226 228 231

Green Tea and EGCG, Teeth and Oral Cavity: Human Studies

For teeth and the oral cavity, mouth rinses, dental floss and chewing gum with green tea extract lowered dental plaque compared with placebo or usual care 95 110 111 121. Compared with chlorhexidine, they performed the same or somewhat weaker 95 110 111. Gum bleeding also decreased in two controlled trials 110 121. For gum inflammation, however, a meta-analysis saw no confirmed benefit for green tea mouth rinses 14. In periodontitis, gum pocket depth decreased more when EGCG solution served as a coolant during cleaning or a green tea gel was applied 14 149 173. After tooth extraction, swabs soaked with green tea extract lowered pain and painkiller use compared with saline 122 135. In advanced head and neck cancer in palliative treatment, a green tea mouth rinse improved the oral condition, but not pain and quality of life 105. After periodontal surgery, a gel of green tea extract and hyaluronic acid worked as well as chlorhexidine gel and caused fewer taste disturbances and discolorations 133. On the palate after removal of a gum graft, a gel of green tea extract and hyaluronic acid brought no difference in wound healing and pain 191.

Study	Design · participants	Preparation · dose · duration · comparison	Result
14 Heuzeroth et al. 2025	meta-analysis · 814 participants	green tea extract as mouthrinse or local delivery; vs. chlorhexidine, control group, turmeric	Gingival Index reduction in gingivitis: unclear (MD = 0.08; 95% CI = 0.01 to 0.14; P = 0.01); probing depth in periodontitis: unclear (MD=-0.79; 95% CI=-1.29 to -0.29 mm; P = 0.002); Gingival Index in periodontitis: unclear (MD=-0.53; 95% CI=-1.01 to -0.05; P = 0.02)
26 Julien et al. 2026	systematic review	Green tea as a bioactive agent, among other foods; vs. Sugar-sweetened beverages and sweets as dysbiosis-promoting	Suppression of cariogenic pathways (Streptococcus mutans): improved
44 Woelber et al. 2023	systematic review	Green tea (beverage) adjunct to non-surgical periodontal therapy; vs. Non-surgical periodontal therapy alone	Pocket probing depth (PPD): improved; Bleeding on probing: improved
95 Sharma et al. 2023	randomised controlled · 90 participants	5% Camellia sinensis mouth rinse; 5% mouth rinse, amount not stated; 21 days; vs. 0.2% chlorhexidine and saline	plaque buildup: improved (1.08 ± 0.11); oral halitosis: improved (1.50 ± 0.50); tongue coating: no difference (0.75 ± 0.36)
105 Roy et al. 2026	randomised controlled · 64 participants	green tea-based mouth rinse; thrice daily; 6 weeks; vs. usual care (control group)	Oral Assessment Guide (OAG): improved (F = 34.32, P = < 0.001); Oral Hygiene Index-Simplified (OHI-S): improved (F = 5.67, P = < 0.001)
110 Sandesh et al. 2026	randomised controlled · 60 participants	5% green tea extract-impregnated dental floss; 5% extract, twice daily; 15 days; vs. 5% chlorhexidine floss, waxed floss, toothbrushing only	Plaque index (Turesky Modified Quigley-Hein): improved (0.86 ± 0.11); Plaque reduction vs. chlorhexidine: no difference (p > 0.05); Gingival bleeding (Modified Sulcular Bleeding Index): improved (p ≤ 0.008)
111 Lile et al. 2025	randomised controlled · 60 participants	mouthrinse with 5% green tea extract; rinsed twice daily for four weeks; 4 weeks; vs. placebo, 0.2% chlorhexidine, 10% propolis	plaque index (Silness-Löe) after 4 weeks: improved (1.12); plaque index versus chlorhexidine: worsened (p = 0.03)
114 Deshpande et al. 2021	randomised controlled · 60 participants	Green tea mouthwash, partly with ginger; 30 days; vs. Chlorhexidine mouthwash	Gingival index: no difference (P < 0.05); Plaque index: no difference (P < 0.05)

Further studies in this area: 121 122 125 128 129 133 135 136 149 163 173 174 191

Green Tea and EGCG and Skin: Human Studies

For skin and hair, a mixed picture emerges. According to a meta-analysis, ingested green tea catechins mitigated skin redness after UV irradiation more strongly than placebo 20. Green tea catechins with vitamin C showed no difference in sunburn and skin inflammation after UV irradiation in a controlled study 119. A second study found only protection of the connective tissue protein fibulin-5 118. A mixed preparation of green tea extract, bamboo extract and selenium improved hair density in acute hair loss compared with placebo 103. Which component acted is open. A face cream with green tea extract in chitosan microparticles improved skin elasticity and wrinkles more strongly than a placebo cream in a split-face comparison 139. A cream of EGCG, vitamin E and grape seed procyanidins reduced the affected area in atopic dermatitis faster than the comparison cream 123. The overall picture improved in both groups 123.

Study	Design · participants	Preparation · dose · duration · comparison	Result
20 Kapoor et al. 2021	meta-analysis · 100 participants	Oral green tea catechins (supplement/extract); 6 to 12 weeks; vs. Placebo	Erythema index after UV exposure (MED 1.25-1.30): improved (SMD: -0.35; 95% CI, -0.57 to -0.13; I2 = 4%, p = 0.40); Pooled difference in erythema index vs. placebo: improved (p = 0.002)
33 Śladowska et al. 2025	systematic review	EGCG alone as saline solution or as shampoo/cream component; vs. Placebo, baseline, or active conventional treatment	Skin symptoms in radiation-induced dermatitis: improved (significant reduction); Seborrheic scalp dermatitis (EGCG shampoo vs. conventional): no difference (similar)
34 Allam et al. 2025	systematic review	Green tea among other herbal remedies; vs. Conventional treatment or control (unspecified)	hair growth, hair density, hair shedding, patient satisfaction: improved
103 Lacetera et al. 2025	randomised controlled · 66 participants	Hair'InsideTM: green tea extract, bamboo extract, selenium; 84 days; vs. placebo, randomized, double-blind	anagen hair density: improved (+10.3 and +15.0 hair/cm2); anagen/telogen ratio: improved (+1.8 and +2.7); telogen hair density: improved (–6.3 and -7.6 hair/cm2)
118 Charoenchon et al. 2022	randomised controlled · 50 participants	Green tea catechins 540 mg plus vitamin C 50 mg or placebo; 540 mg GTC plus 50 mg vitamin C twice daily; 12 weeks; vs. Placebo, double-blind randomized	UVR-induced change in fibulin-5: improved; collagen and elastic fibres in papillary dermis: no difference (P < 0.001); fibrillin-rich microfibrils: no difference (P = 0.02)
119 Farrar et al. 2015	randomised controlled · 50 participants	Encapsulated green tea extract (540 mg GTC) plus vitamin C; 1350 mg extract (540 mg GTC) + 50 mg vitamin C twice daily (1080 mg GTC/d); 3 months; vs. Placebo, double-blind randomized	Sunburn threshold (minimal erythema dose): no difference (28 (20-28) and 20 (20-28) mJ/cm(2)); Erythema index (AUC): no difference; Neutrophil and CD3+ T-lymphocyte infiltration in skin: no difference (P < 0.01)
123 Patrizi et al. 2016	randomised controlled · 44 participants	MD2011001 cream containing vitamin E, EGCG and grape seed procyanidins; 28 days; vs. placebo cream	IGA reduction: improved; reduction in affected surface area: improved (significantly faster)
139 Wisuitiprot et al. 2022	randomised controlled · 29 participants	Green tea extract encapsulated chitosan microparticles (GTP) in emulsion base; 8 weeks, monitored every 2 weeks; vs. Placebo cream on the other half face	Skin elasticity (R2): improved (0.748 ± 0.05 vs 0.722 ± 0.05 at 4th week); Melanin index (skin dullness): improved (placebo =295.60 ± 58.81, GTP =282.70 ± 59.62); Facial wrinkles (photographs): improved

Further studies in this area: 217 221

Green Tea and EGCG and Cancer: Human Studies

In cancer, the controlled studies predominantly found no difference 65 116. With green tea extract, new intestinal adenomas did not occur less often than with placebo 65. In prostate cancer precursors, just as many cancer cases occurred with green tea catechins as with placebo 116. A gene analysis of the intestinal study saw fewer adenomas only in people without a certain transporter gene variant 66. A meta-analysis found recurrence less often with EGCG after removal of intestinal polyps than with placebo 11. A meta-analysis mainly of observational studies found no difference in prostate cancer risk between drinking a lot and a little tea 55. Only above seven cups daily was the risk lower 55. Two meta-analyses of small placebo studies calculated a lower cancer risk for catechin preparations in prostate cancer precursors 19 55. Hypothesis: In observational studies, green tea drinking was associated with less frequent ovarian and uterine cancer 60. Such data do not show whether the tea is the cause.

Study	Design · participants	Preparation · dose · duration · comparison	Result
11 He et al. 2024	meta-analysis · 1,389 participants	EGCG (green tea extract) or placebo; long-term; vs. Placebo	colorectal cancer recurrence rate: improved (Z=2.83, p < 0.05)
19 Perletti et al. 2019	meta-analysis · 223 participants	concentrated green tea catechin extracts; vs. Placebo	prostate cancer risk: improved (risk-ratio = 0.41; 95% CI: 0.19- 0.86; I2 = 0)
49 Grammatikopoulou et al. 2020	systematic review	Green tea catechins, also in combined supplements; vs. Placebo or other intervention in RCTs	PSA concentration: unclear
55 Guo et al. 2017	cohort study	Green tea (beverage) or green tea catechins; Categories of green tea intake, >7 cups/day; vs. highest vs. lowest intake category; catechins vs. control	Prostate cancer incidence (highest vs. lowest category): no difference (no statistical significance); Prostate cancer incidence per 1 cup/day increase: improved (P = 0.08); Prostate cancer risk with >7 cups/day: improved (linearly associated with a reduced risk)
60 Butler et al. 2011	cohort study	Green tea (beverage) and black tea as comparator; vs. Black tea or no tea	Ovarian cancer risk with green tea intake: improved (OR=0.66; 95% CI: 0.54, 0.80); Endometrial cancer risk with green tea intake: improved (OR=0.78, 95% CI: 0.62, 0.98); Ovarian cancer risk with black tea: no difference (OR=0.94, 95% CI: 0.87, 1.02)
65 Seufferlein et al. 2022	randomised controlled · 1,001 participants	Green tea extract standardized to 150 mg EGCG; 150 mg EGCG twice daily; 3 years; vs. Placebo, double-blind, randomized	Adenoma rate (modified ITT): no difference (55.7% in the placebo and 51.1% in the GTE groups); Adenoma rate (per-protocol): no difference (54.3% (151/278) in the placebo group and 48.3% (129/267) in the GTE group)
79 Biernacka et al. 2019	randomised controlled · 133 participants	EGCG capsules 600 mg/day or green tea drink; 600 mg/day EGCG; 6 months; vs. Placebo	Serum IGFBP-3: no difference (205.2 ng/ml; 95% confidence interval: -583.3-172.9, P = 0.3); Serum IGF-I, IGF-II, IGFBP-2: no difference
93 Kumar et al. 2015	randomised controlled · 97 participants	Polyphenon E, decaffeinated green tea catechin mixture; 400 mg EGCG per day; 1 year; vs. Placebo	Prostate cancer cases at one year: no difference (5 of 49 (PolyE) versus 9 of 48 (placebo), P = 0.25); Prostate cancer plus ASAP in men with HGPIN without ASAP: no difference (3 of 26 (PolyE) versus 10 of 25 (placebo), P < 0.024)

Further studies in this area: 97 116 194 198 202 206 209 216 229 230 231 233

Green Tea and EGCG and Liver: Human Studies

For the liver, the picture is inconsistent: Together with brisk walking, AST decreased with green tea extract, but not with placebo 145. With high-dose extract, however, ALT increased, particularly strongly with a certain gene variant 64. A decaffeinated green tea extract confection did not change liver values compared with placebo in healthy people and people with metabolic syndrome 126. In an open-label study, young women received EGCG alone or with clomiphene or letrozole; none showed signs of liver damage 131. Hypothesis: A systematic review, partly with animal studies, sees in EGCG and green tea extract a possible help for fatty liver 46. Hypothesis: A systematic review on polyphenols in fatty liver reports improved liver values for green tea extract 7. Still open is which amount of extract burdens the liver and who, for instance because of their genes, reacts particularly sensitively.

Study	Design · participants	Preparation · dose · duration · comparison	Result
7 Ranneh et al. 2024	systematic review · 1,840 participants	Polyphenol dietary supplementation, including green tea extract; vs. various polyphenol supplements versus control or each other	liver enzymes: improved
15 Brooks et al. 2026	systematic review · 785 participants	Polyphenol supplements incl. EGCG, curcumin, silymarin, cranberry; vs. Control groups of included trials	Hepatoprotective effects of silymarin: improved (potential hepatoprotective effects)
46 Abunofal et al. 2022	systematic review	EGCG or green tea extract (GTE)	lipid and glucose metabolism, expression of lipid synthesis genes: improved; oxidative stress and pro-inflammatory pathways, liver damage: improved
64 Acosta et al. 2023	randomised controlled · 1,075 participants	High-dose green tea extract (capsules) with 843 mg EGCG/day; 843 mg EGCG/day; 12 months; vs. Placebo capsules	AST:ALT ratio change from baseline to month 3: worsened (+1.0% vs -4.8% (p = 0.03)); ALT change from baseline to month 6: worsened (+78.1% vs +28.0% (p < 0.001)); ALT change from baseline to month 9: worsened (+82.1% vs +30.1% (p = 0.004))
112 Pormlikul et al. 2025	randomised controlled · 60 participants	Green tea beverage vs. placebo beverage; 6 weeks; vs. Placebo beverage, randomized double-blind	Liver function tests: no difference (no alterations)
126 Zeng et al. 2024	randomised controlled · 40 participants	Decaffeinated green tea extract confection; 890 mg total catechins per day; 4 weeks; vs. Placebo, double-blind, crossover	Plasma aminotransferases: no difference (P > .05)
145 Zhang et al. 2020	randomised controlled · 24 participants	green tea extract (GTE) tablets; 2 tablets of 150 mg GTE daily; 12-week intervention, 4-week follow-up; vs. placebo plus brisk walking	aspartate aminotransferase: improved (P < 0.01)
199 He et al. 2025	study	Polyphenon E (Theaphenon E), green tea polyphenol extract; 400, 800, 1,200, 1,600, 2,000 mg EGCG daily; 24 weeks; vs. Dose escalation, 3+3 design, no control group	Liver γ-OHPdG levels: improved; VCTE-controlled attenuation parameter: improved

Further studies in this area: 222 227

Green Tea and EGCG: Further Outcomes in Studies

Green tea extract lowered CRP compared with placebo in hospitalized patients with COVID-19 and in overweight women after menopause 101 140. A meta-analysis and a one-year study with high-dose extract, however, found no difference in CRP, IL-6 and TNF-alpha 36 90. Meta-analyses found a higher antioxidant capacity in the blood with green tea supplementation and mostly less malondialdehyde, a marker of oxidative stress 5 16 36. In a one-year extract study, F2-isoprostanes, another marker, remained unchanged 178. In painful diabetic nerve damage, green tea extract relieved pain more strongly than placebo 75. A green tea ointment after episiotomy showed no confirmed group difference 113. Two placebo-controlled matcha studies showed only tendencies in sleep quality and mood; in the sleep EEG, no difference was found 89 176. A heat-treated green tea extract improved memory more strongly than placebo in people with subjective memory problems 98. Matcha and decaffeinated catechins improved individual attention and working memory tests 124 186. In older people with cognitive decline, the main measures remained unchanged with matcha 89. Investigated were mainly green tea extract in capsules or tablets, matcha powder 89 176 and decaffeinated extract 126 186. Statements on dose, preparation and duration remain open, since the studies used very different forms, amounts and comparison groups.

Study	Design · participants	Preparation · dose · duration · comparison	Result
4 Long et al. 2023	meta-analysis · 3,852 participants	Tea polyphenols among 14 other polyphenol sources; vs. Control without added polyphenols	Disease activity score (DAS28): improved; Inflammation markers (CRP, ESR): improved; Oxidative stress: improved
5 Asbaghi et al. 2024	meta-analysis · 3,802 participants	green tea extract (GTE) as dietary supplement; vs. placebo or control	malondialdehyde (MDA): improved (significantly reduced); total antioxidant capacity (TAC): improved (increased)
7 Ranneh et al. 2024	systematic review · 1,840 participants	Polyphenol dietary supplementation, including green tea extract; vs. various polyphenol supplements versus control or each other	inflammatory cytokines: improved
15 Brooks et al. 2026	systematic review · 785 participants	Polyphenol supplements incl. EGCG, curcumin, silymarin, cranberry; vs. Control groups of included trials	Disability (EDSS) with EGCG: no difference (no significant impact on disability); Relapse rate with EGCG: no difference (no significant impact on ... relapse rates); MRI changes with EGCG: no difference (no significant impact on ... MRI outcomes)
16 Rasaei et al. 2021	meta-analysis · 760 participants	Green tea supplementation (form not further specified in abstract); Dose in mg/day examined in meta-regression, specific values not reported; Intervention duration in weeks examined in meta-regression, specific values not reported; vs. Control group (placebo or no supplementation)	Total antioxidant capacity (TAC): improved (WMD: 0.20 mmol/L; 95% CI: 0.09, 0.30, p < 0.001); Malondialdehyde (MDA): no difference; MDA dose-response association (meta-regression): improved (r = -2117.18, p = 0.017)
24 Wójtowicz et al. 2026	systematic review	Dietary supplements, including EGCG; vs. Placebo in randomized trials	Endometriotic lesion size (animal and human studies): unclear; RCT efficacy of EGCG in endometriosis: unclear (no RCTs evaluating the effectiveness of ... EGCG)
25 Marsh et al. 2026	systematic review	Camellia sinensis (green tea), form not specified; vs. placebo or control in included RCTs	processing speed, attention, working memory, language, psychomotor function, overall cognitive performance: no difference (no benefit)
27 Payne et al. 2025	meta-analysis	Tea, theanine alone, or theanine plus caffeine; vs. Placebo	Choice reaction time (hour 1): improved (SMD, -0.48; 95% CI, -1.01, 0.05); Digit vigilance task accuracy (hour 2): improved (SMD, 0.20; 95% CI, 0.02, 0.38); Attention switching task accuracy (hour 2): improved (SMD, 0.33; 95% CI, 0.13, 0.54)

Further studies in this area: 31 32 35 36 40 41 42 48 51 52 54 58 61 62 69 71 72 73 74 75 76 80 81 82 83 84 86 87 88 89 90 92 93 94 96 98 100 101 102 105 106 107 108 109 113 116 117 124 126 127 130 132 134 137 138 140 141 143 146 147 151 153 155 156 157 162 165 169 170 171 172 174 176 177 178 179 180 181 182 183 185 186 188 189 190 192 193 196 197 198 199 200 201 202 203 204 207 208 210 212 214 215 217 218 219 220 221 223 225 231 234

4. How Is Green Tea and EGCG Dosed? Preparation, Dose and Duration in Studies

The infusion from the leaves, green tea extract in capsules or tablets, decaffeinated extract, EGCG-enriched extract and ground leaf powder were studied. For teeth and the oral cavity, mouth rinses, gels, chewing gum, dental floss and soaked pads were also used. Some of the studies tested combination preparations, for example with vitamin C, selenium or hyaluronic acid, or green tea together with exercise. They say nothing about the tea alone.

Preparation or form	Dose	Duration	Study
High-dose green tea extract (capsules) with 843 mg EGCG/day	843 mg EGCG/day	12 months	64
Green tea extract standardized to 150 mg EGCG	150 mg EGCG twice daily	3 years	65
Green tea extract (capsules) versus placebo	—	3 years	66
Green tea extract capsules (two each morning and evening with meals)	843 mg/day EGCG	12 months	67
Green-MED diet with green tea (3-4 cups/day) plus Mankai shake and walnuts	3-4 cups green tea per day	18 months	68
green-MED diet with green tea, walnuts, Mankai	+1240 mg/day polyphenols from walnuts, Mankai, green tea	18 months	69
Green-MED diet with green tea (3-4 cups/d) and Mankai shake	3-4 cups green tea per day	18 months	70
Green-MED diet with green tea (3-4 cups/day), Mankai and walnuts	3-4 cups green tea daily	18 months	71
Beverage with catechins and xanthan gum	high: 3×57 mg catechins + 100 mg xanthan; low: 1×57 mg + 100 mg xanthan	12 weeks (December 2017 to February 2018)	72
Green tea extract capsules, 843 mg EGCG daily	843 mg EGCG daily, two capsules twice daily	12 months	73
Capsules with green tea catechins and theanine	378 mg catechins and 210 mg theanine per day	5 months	74
Green tea extract (GTE)	—	16 weeks	75
Green tea extract capsules with 843.0 mg EGCG or placebo	843.0 mg EGCG daily	12 months	76
oral L-theanine (green tea amino acid)	—	single dose, measured 60 minutes before and after	77
Yabukita or Benifuuki green tea extract powder in capsules	1.8 g/day	12 weeks	78

5. Is Green Tea and EGCG Safe? Side Effects in Studies

In a large placebo-controlled trial, green tea extract was well tolerated, with no substantial differences in adverse events 65. However, high-dose green tea extract can stress the liver. In a large trial, liver values (ALT) rose with it, and markedly more so with a particular gene variant 64. A meta-analysis advises caution with concentrated extracts and, if necessary, monitoring of liver values 12. In a small open-label trial with EGCG, no woman showed signs of liver damage 131. In small trials, green tea and green tea extract led to lower blood levels of nadolol, lisinopril, atorvastatin, rosuvastatin, fexofenadine and nintedanib 144 148 161 164 166 168.

Study	Reported side effects
3 Lagou et al. 2025	minor and low (0.4%)
4 Long et al. 2023	Adding polyphenols did not increase adverse events
12 Zago et al. 2026	Caution with high-dose extracts, monitor hepatic function
15 Brooks et al. 2026	Intervention adverse events generally mild
16 Rasaei et al. 2021	not reported
23 Andrés et al. 2026	Most interventions were well tolerated at the nutritional doses tested
31 Ufomadu et al. 2025	Adverse skin reactions reported
32 Liang et al. 2025	SAEs rare but reported for Camellia sinensis
33 Śladowska et al. 2025	Generally well tolerated, no serious treatment-related adverse events
36 Dehzad et al. 2025	not reported
47 Willcox et al. 2021	no serious adverse effects reported
51 Marx et al. 2020	Adverse events reported for green tea and inosine; caution advised

6. What Remains Open: Limits of the Evidence

The controlled trials are mostly small and short, so long-term effects remain open.
Caffeine content and optimal preparation were rarely compared systematically.
Many findings come from combination preparations and cannot be attributed to green tea or EGCG alone.
For cancer and the liver, it is unclear which form and amount of EGCG has a favorable or unfavorable effect.
Interactions with medicines have been studied only for individual active substances.

7. Bottom Line: What Is Established About Green Tea and EGCG

Green tea and its catechins, especially EGCG, have been studied extensively in controlled trials in humans. The clearest are small reductions in total and LDL cholesterol, blood pressure and body weight in meta-analyses 5 6 9 10. Mouth rinses, dental floss and chewing gum with green tea extract reduced dental plaque and gum bleeding 95 110 111 121.

For cancer, the controlled trials mostly found no difference 65 116. The studies are mostly small and short and use very different forms and amounts. Combination preparations do not allow any statement about the tea alone. Interactions with medicines and possible liver stress with high-dose extracts should be noted 12 64 164 168.

Frequently Asked Questions

How well has Green Tea and EGCG been studied in humans?

Does Green Tea and EGCG help with body weight and metabolism? What the studies show

We evaluated 18 meta-analyses or systematic reviews, 25 controlled studies and 13 further studies; the controlled studies include 900 participants in total. Result of the controlled studies: mixed. Strength of evidence under our published rules: high. Sources: 1 5 7 8

Does Green Tea and EGCG help with heart and circulation? What the studies show

We evaluated 13 meta-analyses or systematic reviews, 22 controlled studies and 12 further studies; the controlled studies include 1,114 participants in total. Result of the controlled studies: mostly improved. Strength of evidence under our published rules: high. Sources: 2 3 6 9

Does Green Tea and EGCG help with teeth and oral cavity? What the studies show

We evaluated 2 meta-analyses or systematic reviews, 18 controlled studies and one further study; the controlled studies include 716 participants in total. Result of the controlled studies: mostly improved. Strength of evidence under our published rules: high. Sources: 14 26 44 95

Does Green Tea and EGCG help with skin? What the studies show

We evaluated one meta-analysis or systematic review, 5 controlled studies and 4 further studies; the controlled studies include 239 participants in total. Result of the controlled studies: mixed. Strength of evidence under our published rules: high. Sources: 20 33 34 103

Does Green Tea and EGCG help with cancer? What the studies show

We evaluated 2 meta-analyses or systematic reviews, 5 controlled studies and 13 further studies; the controlled studies include 1,371 participants in total. Result of the controlled studies: mostly no difference. Strength of evidence under our published rules: moderate. Sources: 11 19 49 55

Does Green Tea and EGCG help with liver? What the studies show

We evaluated one meta-analysis or systematic review, 4 controlled studies and 5 further studies; the controlled studies include 1,199 participants in total. Result of the controlled studies: mostly no difference. Strength of evidence under our published rules: moderate. Sources: 7 15 46 64

Does green tea help with weight loss?

Meta-analyses found only a slight decrease in body weight, BMI and body fat percentage with green tea extract 5 37; drinks with added catechins reduced abdominal fat 13 85. One meta-analysis found no weight difference outside Japan, and a decaffeinated catechin extract did not change weight over one year 59 91.

Does green tea lower blood sugar?

Meta-analyses found slightly lower fasting blood sugar and HbA1c values with green tea, green tea extract or EGCG 17 38 45. An overview of meta-analyses and a meta-analysis in metabolic syndrome, by contrast, found no difference 30 47. The findings come predominantly from short to medium-term studies.

Does green tea help against caries and gum inflammation?

Mouth rinses, dental floss and chewing gum with green tea extract reduced dental plaque and gum bleeding 110 121; in periodontitis, locally applied green tea extract or EGCG reduced gum pocket depth 14 149 173.

Can green tea prevent cancer?

For cancer, the controlled trials mostly found no difference 65 116. With green tea extract, new bowel adenomas did not occur less often than with placebo 65. For prostate cancer precursors, with green tea catechins as many cancer cases occurred as with placebo 116. One meta-analysis found less frequent recurrence with EGCG after removal of bowel polyps 11; in hereditary polyposis, green tea extract showed only a non-confirmed trend 97. Whether drink or extract and which amount of EGCG has an effect remains open.

Is green tea extract safe?

In the controlled trials, green tea extract was mostly well tolerated 65 91. However, high-dose extracts can increase liver values 64; a meta-analysis advises caution here and monitoring of liver values 12. Green tea and extract can also reduce the absorption of medicines such as nadolol and lisinopril 164 168.

Sources

1
Efficacy of dietary supplements as an adjunctive therapy for polycystic ovary syndrome: an umbrella meta-analysis
Wang R, Huang K, Wang M, Zou W, Huang Y, Jiang W et al. · 2025
2
A network meta-analysis on the comparative effect of nutraceuticals on lipid profile in adults
Osadnik T, Goławski M, Lewandowski P, Morze J, Osadnik K, Pawlas N et al. · 2022
3
Impact of flavan-3-ols on blood pressure and endothelial function in diverse populations: a systematic review and meta-analysis of randomized controlled trials
Lagou V, Greyling A, Ferruzzi MG, Skene SS, Dubost J, Demirkan A et al. · 2025
4
Efficacy and safety of dietary polyphenols in rheumatoid arthritis: A systematic review and meta-analysis of 47 randomized controlled trials
Long Z, Xiang W, He Q, Xiao W, Wei H, Li H et al. · 2023
5
The effects of green tea extract supplementation on body composition, obesity-related hormones and oxidative stress markers: a grade-assessed systematic review and dose-response meta-analysis of randomised controlled trials
Asbaghi O, Rezaei Kelishadi M, Larky DA, Bagheri R, Amirani N, Goudarzi K et al. · 2024
6
Effect of green tea consumption on blood lipids: a systematic review and meta-analysis of randomized controlled trials
Xu R, Yang K, Li S, Dai M, Chen G · 2020
7
Polyphenol Intervention Ameliorates Non-Alcoholic Fatty Liver Disease: An Updated Comprehensive Systematic Review
Ranneh Y, Bedir AS, Abu-Elsaoud AM, Al Raish S · 2024
8
Comparative effects of tea and coffee drinking on body weight in adults: a systematic review and network meta-analysis of randomised trials
Jayedi A, Norouziasl R, Aletaha A, Mirrafiei A, Soltani A, Shab-Bidar S · 2024
9
Effect of green tea supplementation on blood pressure: A systematic review and meta-analysis of randomized controlled trials
Xu R, Yang K, Ding J, Chen G · 2020
10
Green tea catechins decrease total and low-density lipoprotein cholesterol: a systematic review and meta-analysis
Kim A, Chiu A, Barone MK, Avino D, Wang F, Coleman CI et al. · 2011
11
Chemoprophylaxis Effect of EGCG on the Recurrence of Colorectal Cancer: A Systematic Review and Meta-Analysis
He B, Kang S, Su R, Wu S, Liu X, Liu M et al. · 2024
12
Effects of green tea use on the metabolic profile of postmenopausal women: systematic review and meta-analysis
Zago IHR, Colonetti L, Balbinot EL, Taschetto IS, Grande AJ, da Rosa MI et al. · 2026
13
Efficacy of tea catechin-rich beverages to reduce abdominal adiposity and metabolic syndrome risks in obese and overweight subjects: a pooled analysis of 6 human trials
Hibi M, Takase H, Iwasaki M, Osaki N, Katsuragi Y · 2018
14
Weighing up the potential of "superfoods" compounds of green tea or turmeric as adjuncts in comparison to established therapeutical approaches for periodontal disease
Heuzeroth G, Kaufmann ME, Herter-Aeberli I, Schlagenauf U, Liu CC, Papageorgiou SN et al. · 2025
15
The Effect of Polyphenol Supplementation in People with Multiple Sclerosis: A Systematic Review of Clinical Trials
Brooks L, Farid AFBA, Poobalan A, Johnstone A, Myint PK · 2026
16
Effect of Green Tea Supplementation on Antioxidant Status in Adults: A Systematic Review and Meta-Analysis of Randomized Clinical Trials
Rasaei N, Asbaghi O, Samadi M, Setayesh L, Bagheri R, Gholami F et al. · 2021
17
The effect of green tea on patients with type 2 diabetes mellitus: A meta-analysis
Jia MJ, Liu XN, Liang YC, Liu DL, Li HL · 2024
18
Effects of green tea catechin on the blood pressure and lipids in overweight and obese population-a meta-analysis
Wang Y, Xia H, Yu J, Sui J, Pan D, Wang S et al. · 2023
19
Green tea catechins for chemoprevention of prostate cancer in patients with histologically-proven HG-PIN or ASAP. Concise review and meta-analysis
Perletti G, Magri V, Vral A, Stamatiou K, Trinchieri A · 2019
20
Green Tea Catechin Association with Ultraviolet Radiation-Induced Erythema: A Systematic Review and Meta-Analysis
Kapoor MP, Sugita M, Fukuzawa Y, Timm D, Ozeki M, Okubo T · 2021
21
Effect of Green Tea Extract Supplementation on Substrate Utilization: A GRADE-Assessed Systematic Review and Dose-Response Meta Analysis of Randomized Controlled Trials
Khalilkhaneh AH, Bidsheki MV, Zebari SMS, Talebi S, Mohajerani A, Djafarian K · 2026
22
Nutraceutical enhancement of paraoxonase 1 activity in chronic inflammation: A systematic review of animal-based and plant-based nutraceuticals
Paparozzi J, Barroca C, Gogerdchian H, Girdler M, Akel M, Prashar S · 2026
23
Dietary Polyphenols in Type 2 Diabetes: A Metabolite-Centric Review of Human Evidence
Andrés CMC, Lastra JMP, Bustamante Munguira E, Juan CA, Lebeña EP · 2026
24
The Role of Dietary Supplements in the Treatment of Endometriosis: A Critical Review
Wójtowicz M, Małek P, Olszanecka-Glinianowicz M · 2026
25
The efficacy of nutritional phytochemical compounds in improving cognition
Marsh A, Quelch D, Mackonochie M, Hejmadi M, Rolfe V · 2026
26
The Impact of Children's Dietary Habits on the Oral Microbiome: A Systematic Review
Julien V, Carvalho JP, Andrade JC, Rodrigues CF, Rajão A · 2026
27
Effects of Tea (Camellia sinensis) or its Bioactive Compounds l-Theanine or l-Theanine plus Caffeine on Cognition, Sleep, and Mood in Healthy Participants: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Payne ER, Aceves-Martins M, Dubost J, Greyling A, de Roos B · 2025
28
The impact of consuming technologically processed functional foods enriched/fortified with (poly)phenols on cardiometabolic risk factors: a systematic review of randomized controlled trials
Frumuzachi O, Babotă M, Miere D, Mocan A, Crișan G · 2025
29
Effect of green tea supplementation on blood pressure in adults: a GRADE-assessed systematic review and dose-response meta-analysis of randomised controlled trials
Rezaei M, Akhavan N, Fathi F, Alavi SM, Fadaii M, Dehzad MJ et al. · 2025
30
The Association Between Green Tea Intake and Metabolic Syndrome: A Systematic Review and Meta-analysis of Randomized Controlled Trials
Ghoflchi S, Mohammadi H, Teimouri M, Imani M, Hosseini H · 2025
31
A Review of The Efficacy of Complementary and Alternative Medicines in Managing Dermatologic Infectious Diseases
Ufomadu P, Gill BJ, Shimizu I, Orengo I, Rosen T · 2025
32
Safety Considerations for Natural Products with Adaptogenic and Immunomodulating Activities
Liang CJW, Woerdenbag HJ, Ekhart C, Vitalone A, van Hunsel FPAM · 2025
33
Efficacy and Safety of Epigallocatechin Gallate in the Treatment and Prevention of Dermatitis: A Systematic Review
Śladowska K, Moćko P, Brzostek T, Malinowska-Lipień I, Owca M, Kawalec P · 2025
34
Pathophysiology, conventional treatments, and evidence-based herbal remedies of hair loss with a systematic review of controlled clinical trials
Allam AT, El-Shiekh RA, El-Dessouki AM, Gamil NM, Eisa NM, Ayoub MM et al. · 2025
35
The Impact of Green Tea and Its Bioactive Compounds on Mood Disorder Symptomology and Brain Derived Neurotrophic Factor: A Systematic Review of Randomized Controlled Trials
Cavanah AM, Robinson LA, Mattingly ML, Frugé AD · 2025
36
Effects of green tea supplementation on antioxidant status and inflammatory markers in adults: a grade-assessed systematic review and dose-response meta-analysis of randomised controlled trials
Dehzad MJ, Ghalandari H, Nouri M, Makhtoomi M, Askarpour M · 2025
37
Effects of green tea supplementation on obesity indices and adipokines in adults: a grade-assessed systematic review and dose-response meta-analysis of randomised controlled trials
Dehzad MJ, Ghalandari H, Fahimzad FS, Maghsoudi Z, Makhtoomi M, Nouri M et al. · 2025
38
Effect of Epigallocatechin Gallate on Glycemic Index: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Saadh MJ, Gataa IS, Hussam AS, Kaur I, Kumar A, Godara P et al. · 2025
39
Effects of Exercise Combined With Green Tea in Non-Aging on Anthropometric and Blood Lipids in Non-Aging Overweight/Obesity Adults-A Systematic Review and Network Meta-Analysis
Liu C, Wang Y, Shen Y, Gao Y · 2025
40
Relationship Between Depression and Epigallocatechin Gallate from the Perspective of Gut Microbiota: A Systematic Review
Zhang Y, Liu C, Zhu Q, Wu H, Liu Z, Zeng L · 2025
41
Potential Effects of Bioactive Compounds of Plant-Based Foods and Medicinal Plants in Chronic Kidney Disease and Dialysis: A Systematic Review
Josa E, Barril G, Ruperto M · 2024
42
Effect of Green Tea Supplementation on Inflammatory Markers among Patients with Metabolic Syndrome and Related Disorders: A Systematic Review and Meta-Analysis
de Oliveira Assis FS, Vasconcellos GL, Lopes DJP, de Macedo LR, Silva M · 2024
43
Does green tea catechin enhance weight-loss effect of exercise training in overweight and obese individuals? a systematic review and meta-analysis of randomized trials
Gholami F, Antonio J, Iranpour M, Curtis J, Pereira F · 2024
44
Dietary and Nutraceutical Interventions as an Adjunct to Non-Surgical Periodontal Therapy-A Systematic Review
Woelber JP, Reichenbächer K, Groß T, Vach K, Ratka-Krüger P, Bartha V · 2023
45
The effects of green tea supplementation on cardiovascular risk factors: A systematic review and meta-analysis
Zamani M, Kelishadi MR, Ashtary-Larky D, Amirani N, Goudarzi K, Torki IA et al. · 2022
46
Salubrious Effects of Green Tea Catechins on Fatty Liver Disease: A Systematic Review
Abunofal O, Mohan C · 2022
47
Effectiveness of Medicinal Plants for Glycaemic Control in Type 2 Diabetes: An Overview of Meta-Analyses of Clinical Trials
Willcox ML, Elugbaju C, Al-Anbaki M, Lown M, Graz B · 2021
48
Effect of food sources of nitrate, polyphenols, L-arginine and L-citrulline on endurance exercise performance: a systematic review and meta-analysis of randomised controlled trials
d'Unienville NMA, Blake HT, Coates AM, Hill AM, Hill AM, Nelson MJ et al. · 2021
49
Dietary Factors and Supplements Influencing Prostate Specific-Antigen (PSA) Concentrations in Men with Prostate Cancer and Increased Cancer Risk: An Evidence Analysis Review Based on Randomized Controlled Trials
Grammatikopoulou MG, Gkiouras K, Papageorgiou SΤ, Myrogiannis I, Mykoniatis I, Papamitsou T et al. · 2020
50
Effect of green tea extract on lipid profile in patients with type 2 diabetes mellitus: A systematic review and meta-analysis
Asbaghi O, Fouladvand F, Moradi S, Ashtary-Larky D, Choghakhori R, Abbasnezhad A · 2020
51
The effect of emerging nutraceutical interventions for clinical and biological outcomes in multiple sclerosis: A systematic review
Marx W, Hockey M, McGuinness AJ, Lane M, Christodoulou J, van der Mei I et al. · 2020
52
Botanicals and phytochemicals active on cognitive decline: The clinical evidence
Cicero AFG, Fogacci F, Banach M · 2018
53
Physiological effects of epigallocatechin-3-gallate (EGCG) on energy expenditure for prospective fat oxidation in humans: A systematic review and meta-analysis
Kapoor MP, Sugita M, Fukuzawa Y, Okubo T · 2017
54
Green tea effects on cognition, mood and human brain function: A systematic review
Mancini E, Beglinger C, Drewe J, Zanchi D, Lang UE, Borgwardt S · 2017
55
Green tea and the risk of prostate cancer: A systematic review and meta-analysis
Guo Y, Zhi F, Chen P, Zhao K, Xiang H, Mao Q et al. · 2017
56
Effects of supplementation with green tea catechins on plasma C-reactive protein concentrations: A systematic review and meta-analysis of randomized controlled trials
Serban C, Sahebkar A, Antal D, Ursoniu S, Banach M · 2015
57
Green tea catechins and blood pressure: a systematic review and meta-analysis of randomised controlled trials
Khalesi S, Sun J, Buys N, Jamshidi A, Nikbakht-Nasrabadi E, Khosravi-Boroujeni H · 2014
58
Acute effects of tea constituents L-theanine, caffeine, and epigallocatechin gallate on cognitive function and mood: a systematic review and meta-analysis
Camfield DA, Stough C, Farrimond J, Scholey AB · 2014
59
Green tea for weight loss and weight maintenance in overweight or obese adults
Jurgens TM, Whelan AM, Killian L, Doucette S, Kirk S, Foy E · 2012
60
Green and black tea in relation to gynecologic cancers
Butler LM, Wu AH · 2011
61
Efficacy, safety and tolerability of green tea catechins in the treatment of external anogenital warts: a systematic review and meta-analysis
Tzellos TG, Sardeli C, Lallas A, Papazisis G, Chourdakis M, Kouvelas D · 2011
62
Antioxidants and antiinflammatory dietary supplements for osteoarthritis and rheumatoid arthritis
Rosenbaum CC, O'Mathúna DP, Chavez M, Shields K · 2010
63
Complementary and alternative medicine for the treatment of type 2 diabetes
Nahas R, Moher M · 2009
64
Hepatotoxicity with High-Dose Green Tea Extract: Effect of Catechol-O-Methyltransferase and Uridine 5'-Diphospho-glucuronosyltransferase 1A4 Genotypes
Acosta L, Byham-Gray L, Kurzer M, Samavat H · 2023
65
Green Tea Extract to Prevent Colorectal Adenomas, Results of a Randomized, Placebo-Controlled Clinical Trial
Seufferlein T, Ettrich TJ, Menzler S, Messmann H, Kleber G, Zipprich A et al. · 2022
66
Genomewide association analysis on green tea chemoprevention of colorectal adenoma: the importance of SLCO1A2 variants
Stingl J, Scholl C, Steffens M, Koczera P, Muche R, Rohlmann F et al. · 2025
67
The Effect of 12-Month Green Tea Extract Supplementation and Impact of Catechol-O-Methyltransferase Genotype on Blood Pressure in Women Who Are Post-menopause
· 2021
68
Effect of green mediterranean diet on serum folate and its interaction with genetic variation in folate metabolism: The DIRECT PLUS 18-month dietary randomized controlled trial
Zelicha H, Keller M, Meir AY, Rinott E, Tsaban G, Kaplan A et al. · 2026
69
Serum Galectin-9 and Decorin in relation to brain aging and the green-Mediterranean diet: A secondary analysis of the DIRECT PLUS randomized trial
Pachter D, Yaskolka Meir A, Kaplan A, Tsaban G, Zelicha H, Rinott E et al. · 2025
70
Glycemic control contributes to the neuroprotective effects of Mediterranean and green-Mediterranean diets on brain age: the DIRECT PLUS brain-magnetic resonance imaging randomized controlled trial
Pachter D, Kaplan A, Tsaban G, Zelicha H, Meir AY, Rinott E et al. · 2024
71
The effect of a high-polyphenol Mediterranean diet (Green-MED) combined with physical activity on age-related brain atrophy: the Dietary Intervention Randomized Controlled Trial Polyphenols Unprocessed Study (DIRECT PLUS)
Kaplan A, Zelicha H, Yaskolka Meir A, Rinott E, Tsaban G, Levakov G et al. · 2022
72
Prevention of Acute Upper Respiratory Infections by Consumption of Catechins in Healthcare Workers: A Randomized, Placebo-Controlled Trial
Furushima D, Nishimura T, Takuma N, Iketani R, Mizuno T, Matsui Y et al. · 2019
73
Effect of Green Tea Extract Supplementation and Impact of Catechol-O-Methyltransferase Genotype on Plasma Concentration of F2-Isoprostanes in Women Who Are Post-menopause
· 2022
74
Effects of green tea catechins and theanine on preventing influenza infection among healthcare workers: a randomized controlled trial
Matsumoto K, Yamada H, Takuma N, Niino H, Sagesaka YM · 2011
75
Green tea extract for mild-to-moderate diabetic peripheral neuropathy A randomized controlled trial
Essmat A, Hussein MS · 2021
76
The Effect of Green Tea Extract Supplementation and Different Catechol-O-Methyltransferase Genotypes on Plasma Catechins Concentrations in Women Who Are Post-menopause
· 2022
77
Comparison of the effects of two amino acids, Gamma-aminobutyric acid (GABA) and L-theanine, on sedation, anxiety, and cognition in preoperative surgical patients - A randomized controlled study
Deshpande SS, Kurdi M, Baiju A, Athira AS, Sarasamma AG, Gangadharan AK · 2025
78
Randomized controlled trial of the effects of consumption of 'Yabukita' or 'Benifuuki' encapsulated tea-powder on low-density lipoprotein cholesterol level and body weight
Igarashi Y, Obara T, Ishikuro M, Matsubara H, Shigihara M, Metoki H et al. · 2017
79
Effect of green tea and lycopene on the insulin-like growth factor system: the ProDiet randomized controlled trial
Biernacka KM, Holly JMP, Martin RM, Frankow A, Bull CJ, Hamdy FC et al. · 2019
80
Two-step Randomisation: Applying the Results of Small Feasibility Studies of Interventions to Large-scale Mendelian Randomisation Studies to Robustly Infer Causal Effects on Clinical Endpoints
Sandu MR, Beynon R, Richmond R, Santos Ferreira DL, Hackshaw-McGeagh L, Davey Smith G et al. · 2019
81
ProDiet: A Phase II Randomized Placebo-controlled Trial of Green Tea Catechins and Lycopene in Men at Increased Risk of Prostate Cancer
Lane JA, Lane JA, Er V, Avery KNL, Horwood J, Cantwell M et al. · 2018
82
A multimodal lifestyle intervention complemented with epigallocatechin gallate to prevent cognitive decline in APOE- ɛ4 carriers with Subjective Cognitive Decline: a randomized, double-blinded clinical trial (PENSA study)
Forcano L, Soldevila-Domenech N, Boronat A, Sánchez-Benavides G, Puig-Pijoan A, Lorenzo T et al. · 2025
83
Chronic supplementation of a multi-ingredient herbal supplement increases speed of cognitive task performance alongside changes in the urinary metabolism of dopamine and the gut microbiome in cognitively intact older adults experiencing subjective memory decline: a randomized, placebo controlled, parallel groups investigation
Wightman E, Khan J, Smith E, Rolfe V, Smith D, Young G et al. · 2023
84
Investigating the effects of lycopene and green tea on the metabolome of men at risk of prostate cancer: The ProDiet randomised controlled trial
Beynon RA, Richmond RC, Santos Ferreira DL, Ness AR, May M, Smith GD et al. · 2019
85
Green tea beverages enriched with catechins with a galloyl moiety reduce body fat in moderately obese adults: a randomized double-blind placebo-controlled trial
Kobayashi M, Kawano T, Ukawa Y, Sagesaka YM, Fukuhara I · 2016
86
Interaction between green tea and metformin and its effects on oxidative stress and inflammation in overweight women: a randomised clinical trial
de Oliveira Vogado C, Ferreira MA, Nakano EY, Azevedo S, Magalhães KG, Fernandes Arruda S et al. · 2024
87
Effect of Combined Ingestion of L-Theanine and L-Arginine for Short-Term Psychological Stress in Young Adults: A Randomized Placebo-Controlled Study
Furushima D, Sugiyama I, Nomura Y, Unno K, Yamada H · 2022
88
Efficacy and safety of 7-day aerosolized epigallocatechin-3-gallate in oncologic patients with COVID-19 pneumonia
Zhu W, Jia L, Qiao Q, Li X, Peng X, Meng X et al. · 2026
89
Effect of matcha green tea on cognitive functions and sleep quality in older adults with cognitive decline: A randomized controlled study over 12 months
Uchida K, Meno K, Korenaga T, Liu S, Suzuki H, Baba Y et al. · 2024
90
Effects of Green Tea Extract Supplementation on Inflammatory Cytokines Among Postmenopausal Women with Overweight or Obesity-A Secondary Analysis of a Randomized Controlled Trial
Cunningham A, Gomes A, Meng L, Shapses S, Byham-Gray L, Samavat H · 2026
91
Long-term supplementation of decaffeinated green tea extract does not modify body weight or abdominal obesity in a randomized trial of men at high risk for prostate cancer
Kumar NB, Patel R, Pow-Sang J, Spiess PE, Salup R, Williams CR et al. · 2017
92
Randomized, placebo-controlled trial evaluating the safety of one-year administration of green tea catechins
Kumar NB, Pow-Sang J, Spiess PE, Park J, Salup R, Williams CR et al. · 2016
93
Randomized, Placebo-Controlled Trial of Green Tea Catechins for Prostate Cancer Prevention
Kumar NB, Pow-Sang J, Egan KM, Spiess PE, Dickinson S, Salup R et al. · 2015
94
A combination of green tea extract and l-theanine improves memory and attention in subjects with mild cognitive impairment: a double-blind placebo-controlled study
Park SK, Jung IC, Lee WK, Lee YS, Park HK, Go HJ et al. · 2011
95
Evaluation of the effectiveness of green tea mouth rinse on oral halitosis, tongue coating, and plaque accumulation in comparison with 0.2% chlorhexidine mouth rinse - A double-blind randomized control trial
Sharma P, Chandrashekar BR, Mruthunjaya K, Bhaskar V · 2023
96
A Randomized, Double-Blind, Placebo-Controlled Trial of a Polyphenol Botanical Blend on Sleep and Daytime Functioning
Tubbs AS, Kennedy KER, Alfonso-Miller P, Wills CCA, Grandner MA · 2021
97
Potential of green tea extract to suppress colorectal polyp development in patients with familial adenomatous polyposis: a double-blind, randomized controlled trial Japan Familial Adenomatous Polyposis Prevention Study (J-FAPP Study I)
Ishikawa H, Mutoh M, Yamane T, Wakabayashi K, Hirata K, Iwama T et al. · 2026
98
<b>Effects of Heat-Treated Green Tea Extract on Memory Function and Default Mode Network Connectivity in Individuals with Subjective Memory Impairment: A Randomized, Double-Blinded, Placebo-Controlled Trial</b>
Joo Y, Lee H, Jeong H, Suh C, Hong H, Kim Y et al. · 2025
99
A Double-Blind, Randomized, Placebo-Controlled Study to Evaluate the Efficacy and Safety of STA-2 (Green Tea Polyphenols) in Patients with Chronic Stable Angina
Lee TM, Charng MJ, Tseng CD, Lai LP · 2016
100
Effects of catechin-enriched green tea combined with exercise on physical performance and muscle mass in community-dwelling older adults: A cluster-randomized, placebo-controlled trial
Makizako H, Shiratsuchi D, Miyake Y, Tabira K, Tateishi M, Akaida S et al. · 2026
101
Effects of Green tea supplementation on the CRP, ESR, and CBC in the patients with COVID-19, a double-blind placebo-controlled clinical trial
Yousefi M, Hosseinzade Z, Mahmoodi S, Mahmoodabadi A, Pourmahmoudi A, Saeedinejad Z et al. · 2024
102
Green tea as an adjunctive therapy for treatment of acute uncomplicated cystitis in women: A randomized clinical trial
Kheirabadi Z, Mehrabani M, Sarafzadeh F, Dabaghzadeh F, Ahmadinia N · 2019
103
Preclinical and Clinical Efficacy of a Green Tea, Bamboo, and Selenium Supplement for the Management of Acute Telogen Effluvium in Women
Lacetera J, Pouchieu C, Pourtau L, Monchaux de Oliveira C, Roveda G, Nobile V · 2025
104
The effect of green tea (Camellia sinensis) on lipid profiles and renal function in people with type 2 diabetes and nephropathy: a randomized controlled clinical trial
Yazdanpanah Z, Salehi-Abargouei A, Mozaffari Z, Hemayati R · 2023
105
Effectiveness of green tea (Camellia sinensis) based mouth rinse on oral health status, pain and quality of life among advanced head and neck cancer patients in a tertiary care centre-a randomized controlled trial
Roy M, Dahiya U, Venkatesan L, Garg R, Priya H · 2026
106
A Randomized Controlled Trial to Determine the Effects of Curcumin and Epigallocatechin-3-Gallate Supplementation on Serum Brain-Derived Neurotrophic Factor and Mood Disturbance in Adults
Cavanah AM, Robinson LA, Aguilar MM, Molaison EF, Greene MW, Roberts MD et al. · 2026
107
Effect of a nutraceutical combination on sleep quality among people with mildly impaired sleep: A randomised, placebo-controlled trial
Gutiérrez-Romero SA, Torres-Narváez ES, Zamora-Gómez AC, Castillo-Castillo S, Latorre-Velásquez AL, Betancourt-Villamizar C et al. · 2023
108
Decaffeinated green tea polyphenols supplementation had no adverse health effects in girls with obesity: a randomized controlled trial
Yao D, Xie L, Du K, Yao X, Shen X · 2024
109
Effect of Decaffeinated Green Tea Polyphenols on Body Fat and Precocious Puberty in Obese Girls: A Randomized Controlled Trial
Xie L, Tang Q, Yao D, Gu Q, Zheng H, Wang X et al. · 2021
110
Efficacy of Green Tea Extract-Impregnated Dental Floss Compared to Chlorhexidine and Conventional Floss in Reducing Supragingival Plaque and Gingival Bleeding: A Randomized Controlled Trial
Sandesh N, Johar R, Mishra P, Gupta D, Sontakke S · 2026
111
Comparative Evaluation of Natural Mouthrinses and Chlorhexidine in Dental Plaque Management: A Pilot Randomized Clinical Trial
Lile IE, Hajaj T, Veja I, Hosszu T, Vaida LL, Todor L et al. · 2025
112
The Effect of Green Tea Beverage on Blood Cardiometabolic Risk Biomarkers in Dyslipidemia Subjects
Pormlikul T, On-Nom N, Suttisansanee U, Temviriyanukul P, Trachootham D, Khemthong C et al. · 2025
113
The effect of Camellia sinensis ointment on perineal pain and episiotomy wound healing in primiparous women: A triple-blind randomized clinical trial
Sayahi M, Jahangirimehr A, Hatami Manesh Z, Mojab F, Nikbina M · 2024
114
Effect of green tea, ginger plus green tea, and chlorhexidine mouthwash on plaque-induced gingivitis: A randomized clinical trial
Deshpande A, Deshpande N, Raol R, Patel K, Jaiswal V, Wadhwa M · 2021
115
Green tea extract and catechol-O-methyltransferase genotype modify the post-prandial serum insulin response in a randomised trial of overweight and obese post-menopausal women
Dostal AM, Arikawa A, Espejo L, Bedell S, Kurzer MS, Stendell-Hollis NR · 2017
116
Effect of green tea catechins in patients with high-grade prostatic intraepithelial neoplasia: Results of a short-term double-blind placebo controlled phase II clinical trial
Micali S, Territo A, Pirola GM, Ferrari N, Sighinolfi MC, Martorana E et al. · 2017
117
Essential Amino Acid and Tea Catechin Supplementation after Resistance Exercise Improves Skeletal Muscle Mass in Older Adults with Sarcopenia: An Open-Label, Pilot, Randomized Controlled Trial
Tokuda Y, Mori H · 2023
118
Ultraviolet radiation-induced degradation of dermal extracellular matrix and protection by green tea catechins: a randomized controlled trial
Charoenchon N, Rhodes LE, Nicolaou A, Williamson G, Watson REB, Farrar MD · 2022
119
A randomized controlled trial of green tea catechins in protection against ultraviolet radiation-induced cutaneous inflammation
Farrar MD, Nicolaou A, Clarke KA, Mason S, Massey KA, Dew TP et al. · 2015
120
Effect of Coffee and Tea Consumption on Adolescent Weight Control: An Interventional Pilot Study
Moran-Lev H, Cohen S, Zelber-Sagi S, Mazkeret Mayer E, Anafy A, Yerushalmy-Feler A et al. · 2023
121
The Efficacy of Green Tea Chewing Gum on Gingival Inflammation
Behfarnia P, Aslani A, Jamshidian F, Noohi S · 2016
122
Assessing the Impact of Green Tea Extract on Postoperative Pain Control in Children Undergoing Orthodontic Extractions: A Split-mouth, Randomized, Controlled, Double-blinded Trial
Chakravorty A, Govindaraju L · 2025
123
Randomized, controlled, double-blind clinical study evaluating the safety and efficacy of MD2011001 cream in mild-to-moderate atopic dermatitis of the face and neck in children, adolescents and adults
Patrizi A, Raone B, Neri I, Gurioli C, Carbonara M, Cassano N et al. · 2016
124
Matcha consumption maintains attentional function following a mild acute psychological stress without affecting a feeling of fatigue: A randomized placebo-controlled study in young adults
Baba Y, Kaneko T, Takihara T · 2021
125
Antimicrobial efficacy of disinfecting solutions against S. mutans on toothbrushes for school children in Uttar Pradesh, India
Singh S, Alok A, Shahnawaz K, Kumar S, Ramdas Naik S, Piyush K · 2026
126
A green tea extract confection decreases circulating endotoxin and fasting glucose by improving gut barrier function but without affecting systemic inflammation: A double-blind, placebo-controlled randomized trial in healthy adults and adults with metabolic syndrome
Zeng M, Hodges JK, Pokala A, Khalafi M, Sasaki GY, Pierson J et al. · 2024
127
Assessing brain function in stressed healthy individuals following the use of a combination of green tea, Rhodiola, magnesium, and B vitamins: an fMRI study
Pickering G, Noah L, Pereira B, Goubayon J, Leray V, Touron A et al. · 2023
128
A double blind randomized controlled trial to evaluate the efficacy of green tea in gingivitis
Thakur N, Kumar V, Agarwal A, Kumari S · 2021
129
Effect of Green Tea Extract Mouthwash on Salivary Streptococcus mutans Counts in a Group of Preschool Children: An In Vivo Study
Salama MT, Alsughier ZA · 2019
130
Evaluating the Effect of Epigallocatechin Gallate (EGCG) in Reducing Folate Levels in Reproductive Aged Women by MTHFR and DHFR Genotype in Combination With Letrozole or Clomiphene
Johnson JJ, Siblini H, Al-Hendy A, Segars JH, González F, Taylor HS et al. · 2025
131
Assessing the Hepatic Safety of Epigallocatechin Gallate (EGCG) in Reproductive-Aged Women
Siblini H, Al-Hendy A, Segars J, González F, Taylor HS, Singh B et al. · 2023
132
Green Tea Extract Increases Soluble RAGE and Improves Renal Function in Patients with Diabetic Nephropathy
Barocio-Pantoja M, Quezada-Fernández P, Cardona-Müller D, Jiménez-Cázarez MB, Larios-Cárdenas M, González-Radillo OI et al. · 2021
133
Evaluation of the effects of a gel containing green tea and hyaluronic acid on clinical and Microbiological outcomes following periodontal surgery. A randomized, controlled, double-blinded, noninferiority trial
Gonçalves LS, Melo SS, de Oliveira GJPL, Figueiredo LC, Bezerra FJB, Furlaneto FAC et al. · 2026
134
Acute effects of (-)-gallocatechin gallate-rich green tea extract on the cerebral hemodynamic response of the prefrontal cortex in healthy humans
Cha J, Kim HS, Kwon G, Cho SY, Kim JM · 2023
135
Evaluation of the effect of green tea extract on postoperative pain management following surgical removal of impacted mandibular third molar
Etemadi Sh M, Haghighat A, Fattahi B, Tajmiri G, Alizargar J · 2023
136
Effect of Green Tea on the Level of Salivary Interleukin-1 Beta in Patients with Chronic Periodontitis: A Randomized Clinical Trial
Rezvani G, Taleghani F, Valizadeh M · 2022
137
Does green tea extract enhance the anti-inflammatory effects of exercise on fat loss?
Bagheri R, Rashidlamir A, Ashtary-Larky D, Wong A, Alipour M, Motevalli MS et al. · 2020
138
Changes in pain following an interaction period of resistance training and green tea extract consumption in sedentary hypertensive women: impact of blood pressure swings
Arazi H, Taati B, Kheirkhah J, Ramezanpour S · 2019
139
Effect of green tea extract loaded chitosan microparticles on facial skin: A split-face, double-blind, randomized placebo-controlled study
Wisuitiprot W, Ingkaninan K, Jones S, Waranuch N · 2022
140
A 60-Day Green Tea Extract Supplementation Counteracts the Dysfunction of Adipose Tissue in Overweight Post-Menopausal and Class I Obese Women
Rondanelli M, Gasparri C, Perna S, Petrangolini G, Allegrini P, Fazia T et al. · 2022
141
A randomized placebo-controlled clinical trial of oral green tea epigallocatechin 3-gallate on erythropoiesis and oxidative stress in transfusion-dependent β-thalassemia patients
Settakorn K, Hantrakool S, Petiwathayakorn T, Hutachok N, Tantiworawit A, Charoenkwan P et al. · 2023
142
The Impact of Decaffeinated Green Tea Extract on Fat Oxidation, Body Composition and Cardio-Metabolic Health in Overweight, Recreationally Active Individuals
Roberts JD, Willmott AGB, Beasley L, Boal M, Davies R, Martin L et al. · 2021
143
Gut microbiota-targeted dietary supplementation with fermentable fibers and polyphenols prevents hypobaric hypoxia-induced increases in intestinal permeability
Karl JP, Fagnant HS, Radcliffe PN, Wilson M, Karis AJ, Sayers B et al. · 2025
144
The influence of green tea extract on nintedanib's bioavailability in patients with pulmonary fibrosis
Veerman GDM, van der Werff SC, Koolen SLW, Miedema JR, Oomen-de Hoop E, van der Mark SC et al. · 2022
145
Effects of green tea extract combined with brisk walking on lipid profiles and the liver function in overweight and obese men: A randomized, double-blinded, placebo-control trial
Zhang T, Li N, Chen SI, Hou Z, Saito A · 2020
146
An intervention study on the effect of matcha tea, in drink and snack bar formats, on mood and cognitive performance
Dietz C, Dekker M, Piqueras-Fiszman B · 2017
147
Mixed Flavonoid Supplementation Attenuates Post-Exercise Plasma Levels of Protein Carbonyls and 4-Hydroxynonenal Protein Adducts Levels in Endurance Athletes (P23-009-19)
Wentz L, Nieman D, Valacchi G, Ferrara F, Woodby B, Sakaguchi C et al. · 2019
148
Effect of Green Tea Extract and Soy Isoflavones on the Pharmacokinetics of Rosuvastatin in Healthy Volunteers
Zeng W, Hu M, Lee HK, Wat E, Lau CBS, Ho CS et al. · 2022
149
Efficacy of (-)-epigallocatechin gallate delivered by a new-type scaler tip during scaling and root planing on chronic periodontitis: a split-mouth, randomized clinical trial
Wang Y, Zeng J, Yuan Q, Luan Q · 2021
150
Effect of green tea extract on arterial stiffness, lipid profile and sRAGE in patients with type 2 diabetes mellitus: a randomised, double-blind, placebo-controlled trial
Quezada-Fernández P, Trujillo-Quiros J, Pascoe-González S, Trujillo-Rangel WA, Cardona-Müller D, Ramos-Becerra CG et al. · 2019
151
Effect of cocoa and green tea on biomarkers of glucose regulation, oxidative stress, inflammation and hemostasis in obese adults at risk for insulin resistance
Stote KS, Clevidence BA, Novotny JA, Henderson T, Radecki SV, Baer DJ · 2012
152
Green tea catechins prevent low-density lipoprotein oxidation via their accumulation in low-density lipoprotein particles in humans
Suzuki-Sugihara N, Kishimoto Y, Saita E, Taguchi C, Kobayashi M, Ichitani M et al. · 2016
153
Impact of Green Tea Consumption on Postoperative Ileus in Colon Cancer Patients: A Pilot Randomized Controlled Trial
Watanabe J, Kobayashi F, Tahara M, Kitabayashi H, Shiozawa M, Kondo S et al. · 2024
154
Effects of coffee and tea on postprandial cardiometabolic risk factors in healthy individuals: a randomized crossover trial
Zhang C, Zhang J, Li D, Hu X · 2024
155
Effect of Epigallocatechin Gallate Supplementation on Inflammation, Iron Status, and Metabolomic Profiles in Women With Obesity: A Pilot Randomized Controlled Trial
Aguree S, Turi KN, Handt AR, Kohut M, Reddy MB · 2026
156
Synergistic Effects of Green Tea Extract and Ginger Supplementation on Endurance Performance and Thermal Perception in Normothermic and Cold Environments: A Randomized, Placebo-Controlled, Double-Blind Crossover Trial
Demirli A, Ulupınar S, Terzi M, Özbay S, Özkara AB, Gençoğlu C et al. · 2025
157
A green tea-containing starch confection increases plasma catechins without protecting against postprandial impairments in vascular function in normoglycemic adults
Sapper TN, Mah E, Ahn-Jarvis J, McDonald JD, Chitchumroonchokchai C, Reverri EJ et al. · 2016
158
Time-of-day-dependent effects of a green tea extract on postprandial glycemia and insulinemia in healthy adults: a randomized, controlled, double-blind, cross-over intervention
Sulaimani N, Rosbotham EJ, Warnock R, Polzella L, Judowski R, Nicolotti L et al. · 2025
159
The role of catechol-O-methyl transferase Val(108/158)Met polymorphism (rs4680) in the effect of green tea on resting energy expenditure and fat oxidation: a pilot study
Hursel R, Janssens PL, Bouwman FG, Mariman EC, Westerterp-Plantenga MS · 2014
160
Green Tea Extract Concurrent with an Oral Nutritional Supplement Acutely Enhances Muscle Microvascular Blood Flow without Altering Leg Glucose Uptake in Healthy Older Adults
Din USU, Sian TS, Deane CS, Smith K, Gates A, Lund JN et al. · 2021
161
Effects of Green Tea Extract on Atorvastatin Pharmacokinetics in Healthy Volunteers
Abdelkawy KS, Abdelaziz RM, Abdelmageed AM, Donia AM, El-Khodary NM · 2020
162
Source density analysis of the human EEG after ingestion of a drink containing decaffeinated extract of green tea enriched with L-theanine and theogallin
Dimpfel W, Kler A, Kriesl E, Lehnfeld R, Keplinger-Dimpfel IK · 2007
163
Gel Containing Catechin and Mesoporous Silica Nanoparticles for Protecting Root Dentin Against Erosion: An In Situ Study
Alves HC, Gomes EAB, Uchoa AFJ, Ricardo NMPS, Passos VF, Santiago SL · 2025
164
Effects of single green tea ingestion on pharmacokinetics of nadolol in healthy volunteers
Misaka S, Abe O, Ono T, Ono Y, Ogata H, Miura I et al. · 2020
165
Effect of an herbal supplement on quality of life in participants with insomnia: A randomized placebo controlled cross-over pilot trial
Singh P, Griffith I, Tanksley M, Beyl RA, Greenway F · 2026
166
Exposure of Fexofenadine, but Not Pseudoephedrine, Is Markedly Decreased by Green Tea Extract in Healthy Volunteers
Misaka S, Ono Y, Taudte RV, Hoier E, Ogata H, Ono T et al. · 2022
167
Effect of Green Tea Extract Ingestion on Fat Oxidation during Exercise in the Menstrual Cycle: A Pilot Study
Ishikawa A, Matsuda T, Gam H, Kanno M, Yamada M, Ikegami N et al. · 2022
168
Impact of Green Tea Catechin Ingestion on the Pharmacokinetics of Lisinopril in Healthy Volunteers
Misaka S, Ono Y, Uchida A, Ono T, Abe O, Ogata H et al. · 2021
169
Acute effect of green tea catechins on uric acid metabolism after alcohol ingestion in Japanese men
Kawakami Y, Yasuda A, Hayashi M, Akiyama M, Asai T, Hosaka T et al. · 2021
170
A Combination of Essential Fatty Acids, Panax Ginseng Extract, and Green Tea Catechins Modifies Brain fMRI Signals in Healthy Older Adults
Carmichael OT, Pillai S, Shankapal P, McLellan A, Kay DG, Gold BT et al. · 2018
171
The polyphenol epigallocatechin gallate lowers circulating catecholamine concentrations and alters lipid metabolism during graded exercise in man: a randomized cross-over study
Churm R, Williams LM, Dunseath G, Prior SL, Bracken RM · 2023
172
Effect of regular green tea (<i>Camellia sinensis</i>) kombucha consumption on oxidative stress and endothelial health in individuals with excess body weight: a randomized controlled trial
Bonifácio DB, Macedo Fraiz G, Lacerda UV, Cardoso RR, Pelissari Kravchychyn AC, Corich V et al. · 2025
173
Evaluation of the clinical efficacy of green tea extract gel as local drug delivery for periodontitis
Rengaraj S, Thilagar SS, Yadalam PK, Pampani P, Mani E, Ardila CM · 2025
174
Green Tea Kombucha Impacts Inflammation and Salivary Microbiota in Individuals with Excess Body Weight: A Randomized Controlled Trial
Fraiz GM, Bonifácio DB, Lacerda UV, Cardoso RR, Corich V, Giacomini A et al. · 2024
175
Examination of sex-specific interactions between gut microbiota and host metabolism after 12-week combined polyphenol supplementation in individuals with overweight or obesity
Jardon KM, Goossens GH, Most J, Galazzo G, Venema K, Penders J et al. · 2024
176
Matcha Does Not Affect Electroencephalography during Sleep but May Enhance Mental Well-Being: A Randomized Placebo-Controlled Clinical Trial
Baba Y, Takihara T, Okamura N · 2024
177
Green Tea Epigallocatechin 3-Gallate Reduced Platelet Aggregation and Improved Anticoagulant Proteins in Patients with Transfusion-Dependent β-Thalassemia: A Randomized Placebo-Controlled Clinical Trial
Petiwathayakorn T, Hantrakool S, Settakorn K, Hutachok N, Tantiworawit A, Chalortham N et al. · 2024
178
Green tea extract supplementation does not modify plasma concentration of F2-isoprostanes in women who are postmenopause: Findings from a randomized controlled trial
Bathgate JR, Radler DR, Kurzer M, Samavat H · 2023
179
Effect of fluid replacement with green tea on body fluid balance and renal responses under mild thermal hypohydration: a randomized crossover study
Takamata A, Oka A, Nagata M, Kosugi N, Eguchi S, Sakagawa N et al. · 2023
180
Potential Effect Of Green Tea Extract For Adjuvant Treatment Of Acute Ischemic Stroke by S100ß Upregulation In Non Thrombolysis Patient
Machin A, Suprapto DA, Hanifah A, Suharjanti I, Shodiq J, Fatihuddin MF et al. · 2023
181
Effect of a Combination of Magnesium, B Vitamins, Rhodiola, and Green Tea (L-Theanine) on Chronically Stressed Healthy Individuals-A Randomized, Placebo-Controlled Study
Noah L, Morel V, Bertin C, Pouteau E, Macian N, Dualé C et al. · 2022
182
A Combination of Magnesium, B Vitamins, Rhodiola, and Green Tea (L-theanine) Alleviates Chronic Stress in Healthy Volunteers: A Randomized, Placebo-Controlled Study
· 2022
183
Therapeutic effectiveness of green tea leaf extract on clinical symptoms in children suffering viral gastroenteritis: A randomized clinical trial
Sadeghian M, Torabi A, Torabi S, Vafadar M, Oladi S · 2022
184
The Effect of Green Tea Extract on Individual Components of Metabolic Syndrome in Women Who Are Post-menopause
· 2021
185
(-)-Epicatechin-Enriched Extract from Camellia sinensis Improves Regulation of Muscle Mass and Function: Results from a Randomized Controlled Trial
Seo H, Lee SH, Park Y, Lee HS, Hong JS, Lim CY et al. · 2021
186
Effect of Daily Intake of Green Tea Catechins on Cognitive Function in Middle-Aged and Older Subjects: A Randomized, Placebo-Controlled Study
Baba Y, Inagaki S, Nakagawa S, Kaneko T, Kobayashi M, Takihara T · 2020
187
Impact of short-term flavanol supplementation on fasting plasma trimethylamine N-oxide concentrations in obese adults
Angiletta CJ, Griffin LE, Steele CN, Baer DJ, Novotny JA, Davy KP et al. · 2018
188
Nutraceutical intervention improves older adults' cognitive functioning
Small BJ, Rawson KS, Martin C, Eisel SL, Sanberg CD, McEvoy CL et al. · 2014
189
Health effects of green tea catechins in overweight and obese men: a randomised controlled cross-over trial
Brown AL, Lane J, Holyoak C, Nicol B, Mayes AE, Dadd T · 2011
190
Double-blind, placebo-controlled study of Fertilityblend: a nutritional supplement for improving fertility in women
Westphal LM, Polan ML, Trant AS · 2006
191
Effect of a gel containing green tea extract and hyaluronic acid on palate pain scores and wound healing after free gingival graft: a quasi-randomized controlled clinical trial
Oliveira JA, da Silveira MI, de Oliveira Alves R, Bezerra FJB, de Oliveira GJPL, Pigossi SC · 2023
192
A nutritional supplement for improving fertility in women: a pilot study
Westphal LM, Polan ML, Trant AS, Mooney SB · 2004
193
Interest in complementary and alternative medicine among participants in a study on cancer prevention by green tea extract - results from an expert-based survey of MIRACLE trial participants
Melzer A, Sturm N, Rohlmann F, Muche R, Stingl J, Ettrich TJ et al. · 2025
194
Green tea consumption, primary treatment outcome and survival after a diagnosis of ovarian cancer
Gersekowski K, DeFazio A, Friedlander M, Obermair A, Webb PM · 2025
195
The association between polyphenol consumption and stroke risk factors in Saudi Arabia
Alsharif SN · 2025
196
Prostate health supporting by a novel nutraceutical compound with antioxidant property: Results from a pilot study
Marino C, Magliocchetti M, Di Lieto D, Cione E, Vocca C, Ceccato T et al. · 2026
197
Cognitive and transcriptomic effects of Epigallocatechin gallate in fetal alcohol spectrum disorders
Ramos-Triguero A, Astals-Vizcaino M, Navarro-Tapia E, Vieiros M, Bastons-Compta A, Martínez L et al. · 2026
198
Green Tea Polyphenols Ameliorate Esophagitis rather than Aspirin in a Non-Randomized Prospective Cohort Study
Li X, Zhang Q, Zhang H, Li P, Zhu S, Zhang S et al. · 2026
199
A Phase I Dose-Escalation Study of Polyphenon E in Liver Cirrhosis: Evaluation of Safety and Effect on Liver γ-OHPdG Levels
He AR, Smith CI, Cruz-Correa M, Chakraborty R, Zhang S, Sang S et al. · 2025
200
Dietary Polyphenols in Non-Communicable Chronic Diseases: Neuro-Enteric Mechanisms, Multi-Omics Biomarkers and Translational Opportunities
Akif A, Munami JW, Das R, Shawon NJ · 2026
201
Dietary Bioactives in Alzheimer's Disease: A Critical Appraisal of Clinical Trials and Future Nutritional Strategies
Kumari A, Zeng XA · 2026
202
Dietary polyphenols in colorectal cancer - Mechanisms, clinical evidence, and bioavailability of curcumin, resveratrol, and epigallocatechin-3-gallate: A review
Alqahtani HA · 2026
203
Association Between Selected Flavanols and Isoflavones and Precocious Puberty in Girls-A Scoping Review
Michońska I, Serwin A, Dereń K · 2026
204
Drug repurposing for disease-modifying effects in multiple system atrophy
Jeong SH, Shin JY, Lee PH · 2026
205
Beyond Conventional Therapy: A Comprehensive Review of Herbal, Traditional, and Emerging Interventions for Polycystic Ovary Syndrome
Bashir S, Shah IM, Javeed S, Rafiquee A, Mir B, Hassan Mir R et al. · 2026
206
Plant-Derived Polyphenols in the Fight against Colorectal Cancer
Arjona-Ruiz C, Valdez-Morales EE, Guerrero-Alba R · 2026
207
From Macronutrients to Functional Foods: Nutritional Strategies for Recovery Following High-Intensity Exercise
Farzana HR, Vigriawan GE, Santini A, Nurkolis F · 2026
208
Dietary Antioxidants, Polyphenols, and Vascular Health: Insights From Ultrasound Measurement of Carotid Intima-Media Thickness and Their Association With Cognitive Function in Aging and Neurodegenerative Diseases
Wang L, Luo Z, Liu D · 2026
209
Green tea catechins and prostate cancer: mechanisms, clinical evidence, and safety: a narrative review
Altinoz HB, Sanlier N · 2026
210
Normal serum uric acid gout: a neglected and challenging condition
Yang XH, Zhan XL, Xuan QX, Jin HM, Ye ZB · 2026
211
Consumer Perceptions Influence Supplement Choice: A Narrative Review of Clinically Studied Weight-Management Supplements in Obesity
Lee H, Kwak JH · 2026
212
From Treg, FOXP3 to RBPJ: Linking basic science and clinical medicine
Chen LF, Chen CJ · 2026
213
Tea Bioactive Compounds in Obesity Prevention and Management: Processing-Dependent Composition, Molecular Mechanisms, Human Evidence, and Translational Challenges
Hu Y, Huang G, Soonjae K · 2026
214
The Complex Interplay between Botanical Supplements and the Human Gut Microbiome
Ponte AT, Liu A, Acquah KS, Balunas MJ · 2026
215
Kombucha as a Functional Fermented Beverage: Emerging Clinical Evidence, Proposed Mechanisms, Sensory Dimensions, Cultural Context, and Implications for Global Health
Cohen MM · 2026
216
Green Tea Components: In Vitro and In Vivo Evidence for Their Anticancer Potential in Colon Cancer
Randisi F, Perletti G, Marras E, Gariboldi MB · 2025
217
Flavonoids in atopic dermatitis: mechanisms, delivery innovations, and translational strategies
Li D, Han Y, Zhou J, Chen J, Tey HL, Tan TTY · 2025
218
Herbal Medicines in Autism Spectrum Disorder: Therapeutic Potential, Plant Components, and Dosage Guidelines
Aldekhail NM, Khojah H, Alsaadoun NH, Al-Sanea MM, Alshammari SB, Alhazeemi AH et al. · 2025
219
Epigallocatechin 3-gallate-induced neuroprotection in neurodegenerative diseases: molecular mechanisms and clinical insights
Islam MR, Rauf A, Akter S, Akter H, Al-Imran MIK, Islam S et al. · 2025
220
Plant-based bioactives and oxidative stress in reproduction: anti-inflammatory and metabolic protection mechanisms
Liu X, Zeng T, Zhang E, Bin C, Liu Q, Wu K et al. · 2025
221
Epigallocatechin-Gallate (EGCG): An Essential Molecule for Human Health and Well-Being
Rovaldi E, Di Donato V, Paolino G, Bruno M, Medei A, Nisticò SP et al. · 2025
222
The Safety and Efficacy of Dietary Epigallocatechin Gallate Supplementation for the Management of Obesity and Non-Alcoholic Fatty Liver Disease: Recent Updates
Yan R, Cao Y · 2025
223
Phytotherapy and the Role of Bioactive Compounds in Modulating Mechanisms of Overweight and Obesity Comorbid with Depressive Symptoms-A Scoping Review of Mechanisms of Action
Sochacka K, Lachowicz-Wiśniewska S · 2025
224
Metabolic regulation of obesity by naturally occurring compounds: mechanisms and therapeutic potential
Das M, Yagnik U, Raninga I, Banerjee D · 2025
225
Effects of Dietary Components on Mast Cells: Possible Use as Nutraceuticals for Allergies?
Kaag S, Lorentz A · 2023
226
Nutraceuticals in the Management of Dyslipidemia: Which, When, and for Whom? Could Nutraceuticals Help Low-Risk Individuals with Non-optimal Lipid Levels?
Cicero AFG, Fogacci F, Stoian AP, Vrablik M, Al Rasadi K, Banach M et al. · 2021
227
Green Tea and Epigallocatechin Gallate (EGCG) for the Management of Nonalcoholic Fatty Liver Diseases (NAFLD): Insights into the Role of Oxidative Stress and Antioxidant Mechanism
Tang G, Xu Y, Zhang C, Wang N, Li H, Feng Y · 2021
228
Potential Benefits of Phytochemicals for Abdominal Aortic Aneurysm
Hosseini A, Penson PE, Cicero AFG, Golledge J, Al-Rasadi K, Jamialahmadi T et al. · 2021
229
Cancer Prevention with Green Tea and Its Principal Constituent, EGCG: from Early Investigations to Current Focus on Human Cancer Stem Cells
Fujiki H, Watanabe T, Sueoka E, Rawangkan A, Suganuma M · 2018
230
Challenging the effectiveness of green tea in primary and tertiary cancer prevention
Fujiki H, Imai K, Nakachi K, Shimizu M, Moriwaki H, Suganuma M · 2012
231
Potential role of green tea catechins in various disease therapies: progress and promise
Mak JC · 2012
232
Antiobesity effects of green tea catechins: a mechanistic review
Rains TM, Agarwal S, Maki KC · 2011
233
Chemoprevention of prostate cancer with nutrients and supplements
Van Poppel H, Tombal B · 2011
234
Green tea catechins for treatment of external genital warts
Meltzer SM, Monk BJ, Tewari KS · 2009

Every statement on this page carries its evidence tier — proven, plausible or hypothesis — and leads to the original work. The decision in the individual case rests with the practitioner; we provide the connections.