Almonds
Almonds are the seeds of the almond tree; human studies show mixed effects on blood lipids, weight, inflammation, gut, cognition and blood sugar.
We evaluated 113 human studies on Almonds, including 66 randomised controlled trials and 13 meta-analyses or systematic reviews; the controlled studies include 4,433 participants in total. As of 23 October 2026.
1. What Is Almonds? Occurrence, Origin and Forms
Almonds are the seeds of the almond tree (Prunus dulcis), a member of the rose family from the Mediterranean region and Western Asia. They have long been eaten as food, raw, roasted, or processed into flour, paste, oil and almond drink. Studies examine how eating almonds relates to metabolism, body weight and wellbeing.
The almond tree grows in temperate to warm climates, mainly around the Mediterranean, in Western Asia, in California and in Australia. As a food, almonds are available all year round as a snack, a baking ingredient and the base of almond drinks.
After harvest the fruits are dried and the green hull and the hard shell are removed, leaving the seed with its brown skin. Studies test whole almonds (raw or roasted), defatted almond powder, almond flour, almond paste, almond drink, almond oil and almond skin.
Forms and Preparations Studied
- Whole almonds, raw or roasted
- Almond flour and defatted almond powder
- Almond paste (almond butter)
- Almond milk or almond drink
- Almond oil
- Almond skin and almond bran
Not covered on this page:
- Bitter almond (Prunus amara), which contains amygdalin and is not eaten as a food
- Peanut, which is botanically a legume
- Other tree nuts such as walnut, hazelnut, cashew and pistachio
- Almond flavouring (benzaldehyde) as an added aroma compound
2. What Does Almonds Do? Results by Area
| Area | Result in controlled studies | Strength of evidence | Studies | Participants |
|---|---|---|---|---|
| Heart and metabolism (blood lipids) | mixed | high | 2 meta-analyses · 35 controlled · 20 other | 2,734 |
| Weight, satiety and appetite | mostly no difference | high | 1 meta-analyses · 33 controlled · 10 other | 2,552 |
| Inflammation and oxidative stress | mostly no difference | high | 5 meta-analyses · 17 controlled · 8 other | 639 |
| Gut and microbiome | mixed | high | 1 meta-analyses · 12 controlled · 10 other | 595 |
| Blood glucose and insulin | mixed | low | 1 meta-analyses · 23 controlled · 6 other | 2,074 |
| Cognition and mood | mostly no difference | low | 0 meta-analyses · 10 controlled · 1 other | 443 |
| Skin and skin care | mixed | low | 0 meta-analyses · 4 controlled · 3 other | 67 |
| Other investigations | mostly improved | high | 0 meta-analyses · 10 controlled · 8 other | 546 |
How to read the table: counted are human studies whose results concern the area. “High” means at least one meta-analysis and two controlled studies showing improvement, or at least three controlled studies of which three quarters show improvement, with at least 300 participants in total. “Moderate” means at least two controlled studies showing improvement, as a majority, or one meta-analysis alongside controlled studies. “Low” means one controlled study showing improvement. Where an area has no controlled study, the strength of evidence is at most “low” (result “reviews only” or “observational data only”). Everything else is “unclear”. A study counts as showing improvement when at least half of its outcomes in this area improved. Reviews of combination products do not count as meta-analyses; results that only describe side effects or shares of users do not count as an effect. The same study is counted only once.
3. What the Studies Show in Detail
Almonds, Heart and Metabolism (Blood Lipids): Human Studies
In several randomized studies, whole almonds lowered total cholesterol 15161828 and LDL cholesterol 16185183 compared with control diets. A systematic review of almond studies confirms the LDL reduction 2. Triglycerides fell more strongly than under nut-free diets in two studies 2728, but not in others 4183. Blood pressure remained without difference in several randomized studies 20415383; in one study the systolic value fell more strongly 27; liver fat remained unchanged 3783. For LDL particles, the picture was mixed: small particles fell more strongly than under control diets in one study 79, and under statins the pattern shifted toward smaller particles 52. Vascular function improved in one study compared with usual snacks 83, but not in coronary heart disease 53. Several of these studies were funded by the Almond Board of California, an association of the almond industry 162961. Reviews on nuts in general, in which almonds were only a part, also found lower cholesterol levels 1310. Another meta-analysis on almonds, Brazil nuts, and flaxseeds specifically identified lower total and LDL cholesterol for almonds in coronary heart disease 8. What remains open is the effect on clinical endpoints, the influence of the preparation form, and the transferability to people without increased risk.
| Study | Design · participants | Preparation · dose · duration · comparison | Result |
|---|---|---|---|
| 1 Del et al. 2015 | meta-analysis · 2,582 participants | Tree nuts including almonds, as a mixture; dose-standardized to 1 oz (28.4 g) per day; 3 to 26 weeks; vs. Control arm without nut intervention | Total cholesterol: improved (-4.7 mg/dL; 95% CI: -5.3, -4.0 mg/dL); LDL cholesterol: improved (-4.8 mg/dL; 95% CI: -5.5, -4.2 mg/dL); Apolipoprotein B: improved (-3.7 mg/dL; 95% CI: -5.2, -2.3 mg/dL) |
| 2 Musa-Veloso et al. 2025 | systematic review · 2,485 participants | Almond products as investigational product; at least 4 weeks; vs. Control void of nuts/tree nuts | LDL-C: improved (-0.132 mmol/L; 95% CI: -0.190, -0.075 mmol/L; p < 0.001); TC: improved (-0.160 mmol/L; 95% CI: -0.218, -0.101 mmol/L; p < 0.001); non-HDL-C: improved (-0.204 mmol/L; 95% CI: -0.281, -0.127 mmol/L; p < 0.001) |
| 3 Liu et al. 2020 | meta-analysis · 1,677 participants | Almond-enriched diet compared with other nut-enriched diets; vs. Control, walnut-, pistachio-, hazelnut- and cashew-enriched diets | LDL cholesterol reduction (ranking): improved (ranked second best); Triglyceride reduction: unclear; Total cholesterol reduction: unclear |
| 8 Jia et al. 2024 | meta-analysis · 324 participants | Polyphenol-rich seed foods: almonds, Brazil nut, flaxseed; vs. Control (not further described) | Total cholesterol (almonds): improved (MD = -15.53, 95% CI (-21.97, -9.1), p < 0.00001); LDL cholesterol (almonds): improved (MD = -14.62, 95% CI (-20.92, -8.33), p < 0.00001) |
| 9 Vilela et al. 2024 | meta-analysis | Nuts, predominantly almonds; 28 to 84 g/day; 4 to 72 months; vs. Energy restriction without nuts | Total cholesterol, HDL-c, LDL-c, LDL-c/HDL-c, triglycerides: no difference; Systolic and diastolic blood pressure: no difference |
| 10 Guasch-Ferré et al. 2023 | review | Nuts, including almonds, excluding nut oil; vs. nut-enriched vs. usual diet | Total cholesterol: improved (MD, -0.09 to -0.28 mmol/L); LDL-cholesterol: improved (MD, -0.09 to -0.26 mmol/L); Triglycerides: improved (MD, -0.05 to -0.17 mmol/L) |
| 14 Medina-Vera et al. 2021 | systematic review | Raw almonds (among other antioxidant foods) | Blood lipids: improved (significant differences in blood lipids) |
| 15 Gayathri et al. 2022 | randomised controlled · 400 participants | 43 g almonds per day; 43 g/day; 12 weeks; vs. customary diet avoiding nuts | Total cholesterol: improved (-5.4 mg/dl (-10.2, -0.6); p = 0.03) |
Further studies in this area: 16 18 20 21 23 27 28 29 30 33 35 36 37 38 39 41 43 49 50 51 52 53 56 57 58 59 61 62 64 65 70 76 78 79 88 89 95 102 104 105 106 108 109 112 113 114 115 116 117
Almonds, Weight, Satiety and Appetite: Human Studies
In adults with overweight, prediabetes or metabolic syndrome, waist circumference decreased more than with control diets in several randomized studies 284376. Body or abdominal fat decreased more in further studies 1851. For body weight and BMI, findings without a difference predominated 2025263679. Also in further randomized studies on body weight and body composition, no advantage was shown 374164. Individual studies reported a higher energy intake 2652 or a higher BMI and waist circumference 54. After an almond snack, adults ate less over the rest of the day than after cookies 31, but hunger and satiety did not differ compared with pastries 66. A meta-analysis on almond-based diet in type 2 diabetes found a lower BMI 12; a meta-analysis on nuts under calorie reduction, mostly almonds, found no advantage for weight and body composition 9. The evidence is overall extensive but mixed; predominantly whole almonds were investigated, raw or roasted, some as a replacement for isocaloric snacks, some as a supplement. Where almonds were exchanged for other foods, part of the effect is attributable to the exchange; the study with cookies as a comparison was funded by the Almond Board of California 25. Weight studies on almond flour, almond butter, almond milk and almond oil are still pending.
| Study | Design · participants | Preparation · dose · duration · comparison | Result |
|---|---|---|---|
| 9 Vilela et al. 2024 | meta-analysis | Nuts, predominantly almonds; 28 to 84 g/day; 4 to 72 months; vs. Energy restriction without nuts | Weight loss, BMI, waist and hip circumferences: no difference; Body composition (fat mass, fat-free mass, lean mass): no difference |
| 11 Franco et al. 2022 | systematic review | Almonds, hazelnuts, peanuts, walnuts, nut mix; Walnuts 22.1 g to 56 g; peanuts 56 g; acute and chronic studies; vs. different doses or conventional peanuts | Energy metabolism markers (resting energy expenditure, RQ, DIT): no difference |
| 12 Ojo et al. 2021 | meta-analysis | Almond-based diets; vs. Control | Body mass index: improved (p < 0.05) |
| 16 2022 | randomised controlled · 184 participants | 43 g almonds per day; 43 g/day; 12 weeks; vs. habitual diet excluding nuts in any form; manufacturer-funded | body weight: no difference (1%); body mass index: no difference (1%); waist circumference: no difference (1%) |
| 17 Smith et al. 2022 | randomised controlled · 180 participants | Almonds (whole almonds); 300 kcal/d; 30 days; vs. French fries (with/without herb/spice mix), calorie-matched | Fat mass (DXA): no difference (P = 0.443); Body weight change (3 groups): no difference (P = 0.014) |
| 18 Liu et al. 2017 | randomised controlled · 169 participants | Whole almonds, 56 g daily; 56 g/day; 16 weeks; vs. Control group with iso-caloric high-carbohydrate food | Body fat mass: improved; Body fat percentage: improved (P = 0.019); Visceral fat levels: improved (P < 0.001) |
| 20 Jamshed et al. 2016 | randomised controlled · 150 participants | Pakistani or American almonds, soaked overnight; 10 g/day; 12 weeks (follow-ups at week 6 and 12); vs. No-intervention group (no almonds) | Body weight: no difference (remained fairly constant) |
| 21 Jamshed et al. 2015 | randomised controlled · 150 participants | Whole almonds (Pakistani or American variety); 10 g/day, soaked, skin removed, before breakfast; 12 weeks; vs. No intervention (NI) vs. Pakistani vs. American almonds | Body weight: no difference |
Further studies in this area: 22 23 24 26 27 28 31 33 35 36 37 41 43 46 51 52 54 59 64 66 70 72 74 76 78 79 86 87 89 101 104 106 107 109 113 114
Almonds, Inflammation and Oxidative Stress: Human Studies
Two meta-analyses found lower C-reactive protein with almonds 45, and one of them also found lower interleukin-6, but not in obesity or pre-existing conditions 4. Interleukin-6 also fell in randomized trials in obesity and type 2 diabetes 4168. Two meta-analyses also found less malondialdehyde, a marker of oxidative stress 67. Other randomized trials found no differences in inflammatory and oxidative markers 37577680. In one study with almonds alone and together with dark chocolate, oxidative stress did not differ from usual diet 49. The findings come predominantly from small, short studies in overweight or metabolically abnormal adults. The evidence base is therefore extensive but inconsistent, and the transferability to other forms such as almond flour, almond butter or almond milk is open.
| Study | Design · participants | Preparation · dose · duration · comparison | Result |
|---|---|---|---|
| 1 Del et al. 2015 | meta-analysis · 2,582 participants | Tree nuts including almonds, as a mixture; dose-standardized to 1 oz (28.4 g) per day; 3 to 26 weeks; vs. Control arm without nut intervention | C-reactive protein: no difference |
| 4 Fatahi et al. 2022 | meta-analysis · 847 participants | Almond consumption (form not specified); Effective at <60 g/d; vs. no almond consumption | C-reactive protein (CRP): improved (WMD: -0.25 mg/L; 95% CI: -0.43, -0.06 mg/L); Interleukin-6 (IL-6): improved (WMD: -0.11 pg/mL; 95% CI: -0.21, -0.01 pg/mL); Tumor necrosis factor-alpha (TNF-α): no difference (WMD: -0.05 pg/mL; 95% CI: -0.11, 0.01 pg/mL) |
| 5 Eslami et al. 2025 | meta-analysis · 544 participants | Almonds (whole almonds); vs. Control (no almonds) | C-reactive protein (CRP): improved (WMD, -0.28 mg/L; 95% CI, -0.52, -0.04; p = 0.02); Malondialdehyde (MDA): no difference |
| 6 Kolahi et al. 2025 | meta-analysis · 424 participants | Almonds; > 60 g/day; vs. Control | Malondialdehyde (MDA): improved (WMD = -0.46, p = 0.002); 8-hydroxy-2'-deoxyguanosine (8-OHdG): improved (WMD = -5.83, p < 0.001); Uric acid (UA): improved (WMD = -0.64, p = 0.009) |
| 7 Luo et al. 2023 | meta-analysis · 424 participants | Almond intake (form not specified); vs. Control | Malondialdehyde (MDA): improved (WMD: - 6.63 nmol/ml; 95 % CI: - 8.72 to - 4.54; P < 0.001); Oxidized LDL (Ox-LDL): no difference (Hedges' g: - 0.12; 95 % CI: - 0.34 to 0.10; P = 0.28) |
| 12 Ojo et al. 2021 | meta-analysis | Almond-based diets; vs. Control | C-reactive protein and TNF-α: no difference (p > 0.05) |
| 14 Medina-Vera et al. 2021 | systematic review | Raw almonds (among other antioxidant foods) | Oxidative and inflammatory markers: improved (significant differences in ... oxidative and inflammatory markers) |
| 35 Jung et al. 2018 | randomised controlled · 84 participants | 56 g whole almonds daily as a snack; 56 g/day; 2-week run-in, two 4-week phases, 2-week washout; vs. isocaloric cookies | IL-10: worsened (decreased by almond intake (P ≤ 0.05)); ICAM-1, IL-1β, IL-6: unclear (tended to be lower with almonds); Protein carbonyls, MDA, oxLDL: no difference (Neither the almonds nor cookies altered) |
Further studies in this area: 37 41 44 46 49 53 56 57 58 59 63 68 70 76 80 84 102 104 105 108 109 110
Almonds, Gut and Microbiome: Human Studies
For the gut and microbiome, the evidence is high, but the results are mixed. The diversity of the gut flora increased in two randomized studies compared with crackers or cookies 4042, but not in others 3234. Butyrate in stool was higher after almonds than with control 32, other short-chain fatty acids remained unchanged 3442. In metabolic syndrome, inflammation markers in stool decreased when they were initially elevated 76. For gastrointestinal complaints and intestinal transit, the studies showed no difference 3234; hard stools were less frequent in one study 34. Mostly whole almonds, raw or roasted, as well as almond flour, almond butter and almond skin were studied. It remains open which preparation and amount most favorably influence the gut flora and whether the observed laboratory changes have clinical significance.
| Study | Design · participants | Preparation · dose · duration · comparison | Result |
|---|---|---|---|
| 12 Ojo et al. 2021 | meta-analysis | Almond-based diets; vs. Control | Growth of SCFA-producing gut microbiota: improved |
| 13 Fitzgerald et al. 2021 | systematic review | Nuts (almonds, walnuts, hazelnuts, pistachios) | α-diversity: unclear (two studies reporting a significant shift in α-diversity); β-diversity: unclear (four reporting a significant shift in β-diversity); Bacterial composition (SCFA-producing genera): unclear (an increase in genera capable of producing SCFA: Clostridium, Roseburia, Lachnospira and Dialister) |
| 29 Dikariyanto et al. 2020 | randomised controlled · 107 participants | Dry-roasted whole almonds vs. control mini-muffins; 20% of estimated energy requirement; 6 weeks (after 2-week run-in); vs. Isoenergetic control snacks (mini-muffins); manufacturer-funded | Fecal short chain fatty acids: no difference |
| 32 Creedon et al. 2022 | randomised controlled · 87 participants | Whole almonds or ground almonds (almond flour); 56 g/d; 4 weeks; vs. Isocaloric control in place of habitual snacks | Fecal bifidobacteria: no difference (q = 0.613); Butyrate: improved (P = 0.046); Gut microbiota composition and diversity: no difference |
| 34 Sartori et al. 2026 | randomised controlled · 84 participants | Whole almonds; 56 g/d; 12 weeks; vs. Isocaloric snack | Gut microbiota composition: no difference; Short-chain fatty acid concentrations: no difference; Frequency of hard stools: improved (0.0 [0.1] vs 0.1 [0.4] stools/d, P = 0.002) |
| 39 Dhillon et al. 2023 | randomised controlled · 73 participants | Whole almonds as a snack; 2 oz/day; 8 weeks; vs. Isocaloric control snack of graham crackers (325 kcal/day) | Microbial amino acid biosynthesis, amino sugar and nucleotide sugar metabolism pathways: unclear (p < 0.05) |
| 40 Dhillon et al. 2019 | randomised controlled · 73 participants | Almond snack (whole almonds); 56.7 g/d; 364 kcal; 8 weeks; vs. Isocaloric graham cracker snack (77.5 g/d; 338 kcal/d) | Quantitative alpha-diversity (Shannon index): improved (3% greater); Qualitative alpha-diversity (Chao1 index): improved (8% greater); Abundance of Bacteroides fragilis: improved (decreased ... by 48%) |
| 42 Choo et al. 2021 | randomised controlled · 69 participants | Whole almonds (2 servings daily); 56 g/day; 8 weeks; vs. Isocaloric high-carbohydrate biscuit snack | Fecal microbiota composition: improved (P= .011); Bacterial richness, evenness, and diversity: improved (P< .01); Relative and absolute abundance of Ruminococcaceae (Ruminiclostridium): improved (false discovery rate P = .002) |
Further studies in this area: 67 69 70 76 84 85 92 93 96 100 101 105 109 113 114
Almonds, Blood Glucose and Insulin: Human Studies
Under calorie reduction, fasting glucose and insulin fell equally with and without almonds 79. For insulin resistance, two randomized trials found an improvement compared with control 1516, two others found no difference 2957; HbA1c remained unchanged in several studies 263637. The post-meal blood sugar rise was smaller in randomized trials after almonds than without almonds or after cookies 2331. A randomized trial with whole almonds before meals in prediabetes improved glucose and insulin values as well as glucose fluctuations compared with control 4348. In contrast, a randomized controlled trial with whole almonds in prediabetes reported worse values for insulin sensitivity, postprandial glucose and fasting insulin 54. A meta-analysis on almond-based diet in type 2 diabetes found an advantage only for HbA1c, not for fasting blood sugar, postprandial blood sugar, GLP-1, HOMA-IR or fasting insulin 12. A meta-analysis on nuts under calorie reduction, mostly almonds, found no difference in blood sugar and insulin 9. The addition of almonds to meals of dried fruit and rice lowered their glycemic index in most cases in a small study 71. The strength of evidence is overall low because the studies are mostly small, short and inconsistent in form, amount and comparison; several comparisons exchanged almonds for other foods, so that part of the effect is attributable to the exchange. For almond flour, almond butter, almond milk and almond oil, no controlled findings are available in this area.
| Study | Design · participants | Preparation · dose · duration · comparison | Result |
|---|---|---|---|
| 9 Vilela et al. 2024 | meta-analysis | Nuts, predominantly almonds; 28 to 84 g/day; 4 to 72 months; vs. Energy restriction without nuts | Glycemia and insulinemia: no difference |
| 12 Ojo et al. 2021 | meta-analysis | Almond-based diets; vs. Control | HbA1c: improved (p < 0.05); Fasting blood glucose: no difference (p > 0.05); 2 h postprandial blood glucose: no difference (p > 0.05) |
| 15 Gayathri et al. 2022 | randomised controlled · 400 participants | 43 g almonds per day; 43 g/day; 12 weeks; vs. customary diet avoiding nuts | Oral insulin disposition index (DIo): improved (+ 0.7 mmol/L (0.1, 1.3); p = 0.03); Insulin resistance (HOMA IR): improved (-0.4 (-0.7, -0.04; p = 0.03)); Incremental AUC and MAGE (continuous glucose monitoring): improved |
| 16 2022 | randomised controlled · 184 participants | 43 g almonds per day; 43 g/day; 12 weeks; vs. habitual diet excluding nuts in any form; manufacturer-funded | insulin resistance: improved (−0.5(−1.0–0.0); P = 0.04); fasting glucose: no difference (3%) |
| 17 Smith et al. 2022 | randomised controlled · 180 participants | Almonds (whole almonds); 300 kcal/d; 30 days; vs. French fries (with/without herb/spice mix), calorie-matched | Fasting glucose: no difference (P = 0.985); Fasting insulin: no difference (P = 0.082); HOMA-IR: no difference (P = 0.080) |
| 22 Carter et al. 2023 | randomised controlled · 140 participants | Almonds (AL) vs. isocaloric carbohydrate-rich snack bar (SB); 15% of energy requirement; Acute, 150 minutes post snack; vs. Isocaloric carbohydrate-rich snack bar | C-peptide AUC: improved (47% smaller); GIP AUC: improved (18%, p = 0.005); Glucagon AUC: improved (39% p < 0.001) |
| 23 Tan et al. 2013 | randomised controlled · 137 participants | Whole almonds; 43 g/day; 4 weeks; vs. No almonds (control) and consumption with breakfast, lunch, morning or afternoon snack | Postprandial serum glucose response: improved |
| 26 Hunter et al. 2022 | randomised controlled · 134 participants | Whole almonds with breakfast and afternoon snack; 1·5 oz almonds daily; 6 months; vs. Control group maintaining habitual diet | HbA1c: no difference (A: 5·4 (sem 0·04), C: 5·5 (sem 0·04); P > 0·05) |
Further studies in this area: 28 29 31 36 37 38 41 43 46 54 57 58 59 71 72 76 79 104 106 109 111 114
Almonds, Cognition and Mood: Human Studies
For cognition and mood, the evidence is low; most controlled studies found no difference. Compared with control diet, executive function and processing speed improved in one study in prediabetes 46. In mild to moderate Alzheimer's dementia, memory, orientation and sleep improved more with ground sweet almonds with a little rock sugar than with the previous treatment alone 47. In healthy older adults, memory improved only in the group with the higher almond amount compared with baseline; a confirmed difference from the snack group was lacking 80. Working memory and mood remained unchanged in older adults with overweight 27, as did anxiety and depression with mild complaints 34. After unusual exertion, mood and fatigue with almonds showed no confirmed difference from cereal bars 45. It remains open whether the findings in prediabetes and Alzheimer's dementia can be confirmed in larger and longer studies.
| Study | Design · participants | Preparation · dose · duration · comparison | Result |
|---|---|---|---|
| 27 Coates et al. 2020 | randomised controlled · 128 participants | Almond-enriched diet (whole almonds) vs. nut-free diet; 15% energy; 12 weeks; vs. Isocaloric nut-free diet | Cognitive performance (working memory): no difference; Mood: no difference |
| 34 Sartori et al. 2026 | randomised controlled · 84 participants | Whole almonds; 56 g/d; 12 weeks; vs. Isocaloric snack | Anxiety and depression scores (PHQ-ADS): no difference (11.6 ± 5.3 vs 12.5 ± 5.3; P = 0.945); Functional impairment (intention-to-treat): no difference (9.6 ± 7.0 vs 12.2 ± 8.7, P = 0.055); Functional impairment (per-protocol): improved (9.0 ± 6.4 vs 12.5 ± 9.6; P = 0.015) |
| 44 Nieman et al. 2022 | randomised controlled · 64 participants | Almonds (AL) vs. cereal bar (CB), calorie matched; 57 g almonds per day; 4 weeks before eccentric exercise; vs. Cereal bar (calorie matched) | Post-exercise fatigue: no difference (p = 0.051); Post-exercise tension: improved (p = 0.033) |
| 46 Gulati et al. 2026 | randomised controlled · 60 participants | Almonds, 20% of daily energy; 20% of daily energy as almonds; 24 weeks; vs. isocaloric diet and exercise without almonds | Executive function (One Touch Stockings of Cambridge): improved (β = -2.5, 95% CI: -4.4, -0.6, P = 0.01); Processing speed (reaction time): improved (β = 73.8, 95% CI: 25.7, 122.0, P = 0.003); Processing speed (reaction time): improved (β = 39.3, 95% CI: 9.4, 69.1, P = 0.011) |
| 47 Mohajeri et al. 2026 | randomised controlled · 60 participants | 10 g/day powdered sweet almond plus 1 teaspoon rock candy; 10 g/day almond powder plus 1 teaspoon rock candy; 3 months; vs. continuation of previous prescriptions without almond | MMSE orientation scale: improved (p=0.024); MoCA total score: improved (p=0.001); MoCA memory scale: improved (p=0.005) |
| 64 Siegel et al. 2023 | randomised controlled · 25 participants | whole almonds vs. isocaloric unsalted pretzels; 57 g/day almonds or 86 g/day pretzels; 8 weeks; vs. isocaloric unsalted pretzels (control) | mood (POMS-2): no difference (p > 0.05) |
| 66 Sayer et al. 2017 | randomised controlled · 22 participants | 28 g whole, lightly salted roasted almonds vs. isoenergetic baked food; 28 g almonds; two testing days before and at the end of the 12-week intervention; vs. isoenergetic baked food with equivalent macronutrient content | Neural responses to visual food stimuli: no difference |
| 75 Moitra et al. 2026 | randomised controlled | Whole, unsalted almonds with skin; 60 g daily; 20 weeks; vs. Isocaloric cereal-pulse-based snacks | Anxiety symptoms: unclear (p = 0.016) |
Further studies in this area: 77 80 113
Almonds, Skin and Skin Care: Human Studies
In healthy women, consumption of whole almonds compared with pretzels increased the minimal erythema dose, that is, the UV amount until skin redness; roughness, melanin index, moisture, and sebum remained unchanged 55. In postmenopausal women, wrinkle severity and width decreased more strongly under almonds than under a calorie-matched snack 60. A larger follow-up study found fewer wrinkles and pigmentation compared with baseline 82; skin moisture and water loss did not differ 6082. In young adults with mild to moderate acne, lesions decreased more strongly under whole almonds than under a calorie-matched cereal-legume snack 75. The evidence is weak: these are few, small randomized controlled studies with a total of 67 participants, mostly against a calorie-matched snack, so part of the effect may be due to the exchange. Mostly whole almonds were studied; for almond flour, almond paste, almond milk, almond oil, and almond bran, no controlled findings are available for the skin.
| Study | Design · participants | Preparation · dose · duration · comparison | Result |
|---|---|---|---|
| 55 Li et al. 2021 | randomised controlled · 39 participants | Whole almonds orally; 1.5 oz almonds daily; 12 weeks; vs. 1.8 oz pretzels daily | Minimal erythema dose (MED): improved; Allergan roughness: no difference; Melanin index: no difference |
| 60 Foolad et al. 2019 | randomised controlled · 28 participants | Almonds as 20% of daily energy intake; 20% of daily energy intake; 16 weeks; vs. Calorie-matched snack | Wrinkle severity and width: improved (p < .02); Transepidermal water loss: no difference (p = .65) |
| 75 Moitra et al. 2026 | randomised controlled | Whole, unsalted almonds with skin; 60 g daily; 20 weeks; vs. Isocaloric cereal-pulse-based snacks | Total lesion counts: unclear (-22.2% vs. -9.8%); Inflammatory lesion counts: unclear (-8.3% vs. +12%); Non-inflammatory lesion counts: unclear (-26.1% vs. -20.4%) |
| 82 Rybak et al. 2021 | randomised controlled | Almonds as 20% of daily energy intake; 20% of daily energy intake; 24 weeks; vs. Calorie-matched snack | Wrinkle severity: unclear (15% and 16%); Facial pigment intensity: unclear (20%); Skin hydration: no difference |
| 101 Bridges et al. 2023 | cross-sectional study | Plant-based pediatric drink based on almonds and buckwheat; vs. no comparison (retrospective parent survey) | skin rash reduced: improved (over 75%) |
| 107 Mohammadian-Dameski et al. 2025 | review | Sweet almond oil, topical anointment; vs. Comparison of traditional Persian use with modern studies | dry skin prevention and growth promotion in newborns: improved |
| 113 Dreher et al. 2021 | review | Almonds (whole almonds); 42.5 g/day or more; over 6 weeks; vs. Control diets | facial skin aging from UVB exposure: improved (reduced rate) |
Almonds: Further Outcomes in Studies
In coronary heart disease, uric acid in the blood fell more with almonds than without almonds 20. After unusual muscle exertion, strength was better maintained with almonds than with control snacks 4563, but not in another study 64; muscle pain subsided in two studies 6364. The studies in this area were mostly small and short; for almond milk, almond skin and almond bran, controlled studies are still pending.
| Study | Design · participants | Preparation · dose · duration · comparison | Result |
|---|---|---|---|
| 19 Jamshed et al. 2021 | randomised controlled · 150 participants | Whole almonds, Pakistani and American varieties; 10 g/day; 12 weeks; vs. Control group with no intervention | Serum aspartate transaminase: improved (p<0.05); Serum alanine transaminase: improved (p<0.05); Serum gamma-glutamyl transferase: improved (p<0.05) |
| 20 Jamshed et al. 2016 | randomised controlled · 150 participants | Pakistani or American almonds, soaked overnight; 10 g/day; 12 weeks (follow-ups at week 6 and 12); vs. No-intervention group (no almonds) | Serum uric acid: improved (-13 to -16 % less in PA and AA); Serum uric acid (week 12): improved (-14 to -18 % less) |
| 43 Gulati et al. 2023 | randomised controlled · 66 participants | Whole almonds, 20 g, 30 minutes before main meals; 20 g before each main meal; 3 months; vs. Control group without almonds (open-label parallel arms) | Handgrip strength: improved (p < 0·001 for all) |
| 44 Nieman et al. 2022 | randomised controlled · 64 participants | Almonds (AL) vs. cereal bar (CB), calorie matched; 57 g almonds per day; 4 weeks before eccentric exercise; vs. Cereal bar (calorie matched) | Leg-back strength: improved (p = 0.029); Delayed onset of muscle soreness (DOMS): no difference; Serum creatine kinase immediately post-exercise: improved (p = 0.034) |
| 47 Mohajeri et al. 2026 | randomised controlled · 60 participants | 10 g/day powdered sweet almond plus 1 teaspoon rock candy; 10 g/day almond powder plus 1 teaspoon rock candy; 3 months; vs. continuation of previous prescriptions without almond | Pittsburgh Sleep Quality Index: improved (p<0.001) |
| 63 Rayo et al. 2024 | randomised controlled · 26 participants | Raw, shelled almonds vs. isocaloric pretzel; 2 oz/d; 8-wk adaptation, then 3-d recovery; vs. Isocaloric pretzel (control) | Creatine kinase at 72 h: unclear (Δ - 50% from peak); Maximal torque at 120°/s flexion at 24 h: improved (Δ + 12% between trials); Maximal torque at 120°/s flexion at 72 h: improved (Δ + 9% between trials) |
| 64 Siegel et al. 2023 | randomised controlled · 25 participants | whole almonds vs. isocaloric unsalted pretzels; 57 g/day almonds or 86 g/day pretzels; 8 weeks; vs. isocaloric unsalted pretzels (control) | muscle soreness during physical task (72 h AUC): improved (reduced by ~24%); maintenance of vertical jump performance: improved (p < 0.05); CK response to exercise: no difference (p > 0.05) |
| 73 Esquius et al. 2020 | randomised controlled · 5 participants | Almond or placebo supplement; Acute, 2 hours before exercise; vs. Almond vs. placebo | Non-esterified fatty acids (NEFA): improved (0.09 mg·dL-1 (95% CI: 0.05-0.14; p < 0.001)); Cycling performance: improved (5389 ± 1795 W vs. placebo 4470 ± 2053 W, p = 0.043) |
Further studies in this area: 75 81 90 91 94 97 98 99 101 103
4. How Is Almonds Dosed? Preparation, Dose and Duration in Studies
The studies tested predominantly whole almonds, raw, dry roasted or soaked overnight, some with and some without the skin. Individual investigations used almond flour, defatted almond powder, almond butter, almond oil as well as mixtures with other nuts or foods. For almond milk, almond skin and almond bran, only few or no controlled findings are available.
| Preparation or form | Dose | Duration | Study |
|---|---|---|---|
| 43 g almonds per day | 43 g/day | 12 weeks | 15 |
| 43 g almonds per day | 43 g/day | 12 weeks | 16 |
| Almonds (whole almonds) | 300 kcal/d | 30 days | 17 |
| Whole almonds, 56 g daily | 56 g/day | 16 weeks | 18 |
| Whole almonds, Pakistani and American varieties | 10 g/day | 12 weeks | 19 |
| Pakistani or American almonds, soaked overnight | 10 g/day | 12 weeks (follow-ups at week 6 and 12) | 20 |
| Whole almonds (Pakistani or American variety) | 10 g/day, soaked, skin removed, before breakfast | 12 weeks | 21 |
| Almonds (AL) vs. isocaloric carbohydrate-rich snack bar (SB) | 15% of energy requirement | Acute, 150 minutes post snack | 22 |
| Whole almonds | 43 g/day | 4 weeks | 23 |
| Whole almonds compared with biscuits | 10% of total energy requirements or 1030 kJ (42.5 g almonds), whichever was greater | 1 year | 24 |
| Whole almonds with breakfast and afternoon snack | 1·5 oz almonds daily | 6 months | 26 |
| Almond-enriched diet (whole almonds) vs. nut-free diet | 15% energy | 12 weeks | 27 |
| 50 g whole almonds daily in hypocaloric diet | 50 g almonds per day | 3 months | 28 |
| Dry-roasted whole almonds vs. control mini-muffins | 20% of estimated energy requirement | 6 weeks (after 2-week run-in) | 29 |
| Whole almonds as snack | 20% of daily estimated energy requirement | 6 weeks | 30 |
5. Is Almonds Safe? Side Effects in Studies
Gut complaints hardly increased in the studies 3284. Body weight mostly remained unchanged 2536, but in prediabetes BMI and waist circumference increased in one study 54. In a European anaphylaxis registry, almonds were a frequent trigger in adults after hazelnut and walnut 90.
| Study | Reported side effects |
|---|---|
| 32 Creedon et al. 2022 | No effect on gut symptoms |
| 36 Huang et al. 2024 | none reported; almonds hedonically well-tolerated |
| 53 Chen et al. 2015 | no untoward effect reported |
| 60 Foolad et al. 2019 | No adverse effects reported |
| 73 Esquius et al. 2020 | No gastrointestinal disturbances |
| 84 Burns et al. 2016 | Minimal changes in gastrointestinal symptoms |
| 90 Höfer et al. 2025 | anaphylaxis, low adrenaline use |
| 99 Garland et al. 2020 | Oxalate nephropathy with creatinine rise, glomerulosclerosis, fibrosis and calcium oxalate deposition |
| 101 Bridges et al. 2023 | none reported |
| 107 Mohammadian-Dameski et al. 2025 | Minimal adverse effects observed in studies |
6. What Remains Open: Limits of the Evidence
- Most studies are small and short; clinical endpoints such as heart attack or stroke were not tested.
- The preparation form was rarely compared directly, so it remains unclear whether whole almonds, almond flour, almond butter or almond milk act differently.
- Where almonds were exchanged for other foods, part of the effect is attributable to the exchange.
- Several studies were funded by the almond industry; their findings need independent replication.
- The transferability to people without increased cardiovascular or metabolic risk is open.
7. Bottom Line: What Is Established About Almonds
Almonds are the seeds of the almond tree (Prunus dulcis) from the rose family (Rosaceae) and have long been consumed raw, roasted or as flour, butter, oil and almond milk. Human studies show a mixed picture: several controlled studies with whole almonds found more favorable blood lipid levels, a better waist circumference and a more favorable fat distribution as well as lower inflammation and oxidation markers. Other controlled studies saw no differences in cholesterol, blood pressure, liver fat or body weight, and individual ones even reported less favorable values. For blood sugar, skin and cognition, the evidence is low; randomized studies on almond milk, almond skin and almond bran are still pending. The findings apply to the form and preparation studied in each case; where almonds were exchanged for other foods, part of the effect is attributable to the exchange.
Frequently Asked Questions
How well has Almonds been studied in humans?
We evaluated 113 human studies on Almonds, including 66 randomised controlled trials and 13 meta-analyses or systematic reviews; the controlled studies include 4,433 participants in total. As of 23 October 2026.
Does Almonds help with heart and metabolism (blood lipids)? What the studies show
Does Almonds help with weight, satiety and appetite? What the studies show
Does Almonds help with inflammation and oxidative stress? What the studies show
Does Almonds help with gut and microbiome? What the studies show
Does Almonds help with blood glucose and insulin? What the studies show
Does Almonds help with cognition and mood? What the studies show
Which almond form was most frequently investigated in the studies?
Most controlled studies tested whole almonds, raw, dry roasted or soaked overnight, some with and some without the skin. Almond flour, defatted almond powder, almond butter and almond oil were investigated less frequently. For almond milk, almond skin and almond bran, hardly any controlled findings are available.
Do almonds show an effect on blood lipids?
Several randomized studies found lower total or LDL cholesterol with whole almonds than with control diets 1516185183, and individual ones also lower triglycerides 2728. Other randomized studies found no difference in total and LDL cholesterol or triglycerides 374158; with statins, only non-HDL cholesterol decreased 52. For LDL particles, the picture was mixed: small particles decreased more than with control diets in one study 79, with statins the pattern shifted toward smaller particles 52.
Do almonds help with weight loss?
For body weight and BMI, findings without a difference predominated in randomized studies 2025263679. Waist circumference or abdominal fat, by contrast, developed more favorably than with control diets in several randomized studies 2843761851. Individual studies reported a higher energy intake 2652 or a higher BMI and waist circumference 54.
How well tolerated are almonds in the studies?
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Every statement on this page carries its evidence tier — proven, plausible or hypothesis — and leads to the original work. The decision in the individual case rests with the practitioner; we provide the connections.