Knowledge · Natural Compounds

Turmeric and Curcumin

Q: Does Turmeric and Curcumin help with metabolism and blood values? What the studies show

We evaluated 24 meta-analyses or systematic reviews, 90 controlled studies and 16 further studies; the controlled studies include 5,919 participants in total. Result of the controlled studies: mostly improved. Strength of evidence under our published rules: high. Sources: [2, 3, 4, 8]

Q: Does Turmeric and Curcumin help with inflammation-related conditions? What the studies show

We evaluated 17 meta-analyses or systematic reviews, 94 controlled studies and 22 further studies; the controlled studies include 6,429 participants in total. Result of the controlled studies: mostly improved. Strength of evidence under our published rules: high. Sources: [4, 5, 7, 11]

Q: Does Turmeric and Curcumin help with joints and the musculoskeletal system? What the studies show

We evaluated 16 meta-analyses or systematic reviews, 43 controlled studies and 20 further studies; the controlled studies include 3,339 participants in total. Result of the controlled studies: mostly improved. Strength of evidence under our published rules: high. Sources: [6, 7, 11, 12]

Q: Does Turmeric and Curcumin help with absorption in the body? What the studies show

We evaluated one meta-analysis or systematic review, 28 controlled studies and 7 further studies; the controlled studies include 1,077 participants in total. Result of the controlled studies: mostly improved. Strength of evidence under our published rules: high. Sources: [73, 79, 116, 126]

Q: Does Turmeric and Curcumin help with digestion? What the studies show

We evaluated 4 meta-analyses or systematic reviews, 13 controlled studies and 2 further studies; the controlled studies include 511 participants in total. Result of the controlled studies: mostly improved. Strength of evidence under our published rules: high. Sources: [51, 85, 91, 94]

Q: Does Turmeric and Curcumin help with tolerability and safety? What the studies show

We evaluated 2 meta-analyses or systematic reviews, 13 controlled studies and 89 further studies; the controlled studies include 1,732 participants in total. Result of the controlled studies: mostly no difference. Strength of evidence under our published rules: high. Sources: [6, 7, 9, 11]

Q: What is the difference between turmeric and curcumin?

Turmeric is the dried and ground rhizome of Curcuma longa, a plant from the ginger family. Curcumin is the yellow colouring of the rhizome and belongs to the group of curcuminoids. Turmeric traditionally serves as a spice and colouring agent.

Q: Which forms of curcumin were investigated in the studies?

Ground turmeric rhizome powder, curcuminoid-rich extracts, curcumin with piperine from black pepper, curcumin in phytosome form as well as individual curcuminoids and hydrogenated curcumin were investigated. Some of the studies tested mixed preparations with other substances. The absorption findings apply only to the specific form investigated in each case.

Q: How well is curcumin tolerated?

Several controlled studies and reviews described curcuminoids, curcumin in phytosome form and hydrogenated curcuminoids as well tolerated [85, 89, 159, 228, 279]. Liver and kidney values remained unremarkable [110], the liver enzymes also under micellar curcuminoids [247]. For gastrointestinal side effects, the picture was mixed, and due to the mostly short study duration, the findings can only be transferred to long-term use to a limited extent.

Turmeric is the ground rhizome of Curcuma longa, curcumin its yellow colouring; human studies show improvements in metabolism, inflammation and joints.

Last updated: 2026-10-15

We evaluated 375 human studies on Turmeric and Curcumin, including 242 randomised controlled trials and 101 meta-analyses or systematic reviews; the controlled studies include 16,291 participants in total. As of 4 October 2026.

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1. What Is Turmeric and Curcumin? Occurrence, Origin and Forms

Turmeric is the dried and ground rhizome (rootstock) of Curcuma longa, a plant in the ginger family. Curcumin is the yellow pigment of the rhizome and belongs to the group of curcuminoids. Turmeric is traditionally used as a spice and colouring.

Curcuma longa is cultivated in tropical regions of Asia; the part used is the underground rhizome, where the curcuminoids are located. The plant needs a warm, humid climate and is propagated through the rhizome.

For the spice and for extracts the rhizome is dried and ground; curcumin extracts are made from that powder and adjusted to a defined curcuminoid content. Studies examine, among other forms, the powder, extracts, preparations with additives meant to improve absorption, and individual curcuminoids.

Forms and Preparations Studied

Turmeric powder from the ground rhizome
Curcuminoid-rich extract
Curcumin with piperine from black pepper
Curcumin in phytosome form
Individual curcuminoids such as demethoxycurcumin and bisdemethoxycurcumin
Hydrogenated curcumin (tetrahydrocurcumin)

Not covered on this page:

Other Curcuma species such as zedoary (Curcuma zedoaria) and Javanese turmeric (Curcuma xanthorrhiza)
Other ginger-family plants such as ginger (Zingiber officinale) and galangal (Alpinia)
The essential oil obtained from turmeric, which contains no curcuminoids

2. What Does Turmeric and Curcumin Do? Results by Area

Area	Result in controlled studies	Strength of evidence	Studies	Participants
Metabolism and blood values	mostly improved	high	24 meta-analyses · 90 controlled · 16 other	5,919
Inflammation-related conditions	mostly improved	high	17 meta-analyses · 94 controlled · 22 other	6,429
Joints and the musculoskeletal system	mostly improved	high	16 meta-analyses · 43 controlled · 20 other	3,339
Absorption in the body	mostly improved	high	1 meta-analyses · 28 controlled · 7 other	1,077
Digestion	mostly improved	high	4 meta-analyses · 13 controlled · 2 other	511
Tolerability and safety	mostly no difference	high	2 meta-analyses · 13 controlled · 89 other	1,732
Other investigations	mixed	high	22 meta-analyses · 127 controlled · 34 other	8,900

How to read the table: counted are human studies whose results concern the area. “High” means at least one meta-analysis and two controlled studies showing improvement, or at least three controlled studies of which three quarters show improvement, with at least 300 participants in total. “Moderate” means at least two controlled studies showing improvement, as a majority, or one meta-analysis alongside controlled studies. “Low” means one controlled study showing improvement. Where an area has no controlled study, the strength of evidence is at most “low” (result “reviews only” or “observational data only”). Everything else is “unclear”. A study counts as showing improvement when at least half of its outcomes in this area improved. Reviews of combination products do not count as meta-analyses; results that only describe side effects or shares of users do not count as an effect. The same study is counted only once.

3. What the Studies Show in Detail

Turmeric and Curcumin, Metabolism and Blood Values: Human Studies

For metabolism and blood values, curcumin showed improvements in fasting blood glucose 4 8 22 39 43 87 and HbA1c 8 22 43 87 106 110 in several controlled studies. Insulin resistance also improved in several controlled studies 4 69 70 106 140 316, as did liver enzymes 4 44 67 168 220 and markers of oxidative stress 39 112 140 174. Curcuminoid-rich extracts, curcumin in phytosome form and partly unspecified preparations were investigated; the robustness is high, as 24 meta-analyses and 90 controlled studies with a total of 5919 participants are available. A randomised controlled study in healthy older people found elevated blood glucose under lipidated curcumin 170. Many studies do not precisely state form, curcuminoid content and duration of administration, and information on manufacturer funding is largely missing.

Study	Design · participants	Preparation · dose · duration · comparison	Result
2 Wang et al. 2025	meta-analysis · 30,133 participants	Dietary supplements, including curcumin; vs. Control groups of included randomized trials	Fasting glucose: improved (SMD = -3.43)
3 Wan et al. 2024	meta-analysis · 17,126 participants	Polyphenol antioxidant supplements, including curcumin; vs. Control groups of the included randomized trials	indicators of glucose metabolism: improved
4 Jafari et al. 2024	meta-analysis · 7,216 participants	Curcuma longa L. (form not specified in abstract); vs. Placebo	Fasting blood sugar: improved; High-density lipoprotein: improved; Weight: improved
8 Amgain et al. 2025	meta-analysis · 3,706 participants	Curcumin (turmeric extract); exact form not reported; vs. Placebo or control (RCTs within reviews)	Fasting blood glucose: improved (MD = - 6.30 mg/dL; 95% CI: - 9.33, - 3.27); HbA1c: improved (MD = - 0.31%; 95% CI: - 0.57, - 0.05); LDL cholesterol: improved (MD = - 5.95 mg/dL; 95% CI: - 9.43, - 2.47)
13 Ranneh et al. 2024	systematic review · 1,840 participants	Dietary polyphenol supplementation, including turmeric and curcumin; vs. Control groups of the included RCTs	liver enzymes: improved; lipid profile: improved; insulin resistance: improved
19 Xie et al. 2026	meta-analysis · 1,502 participants	Dietary polyphenols, including curcuminoids, flavonoids, stilbenes; Recommendation: long-term over 8 weeks; vs. Polyphenol supplementation versus control	Serum uric acid: no difference (non-significant effects); Serum uric acid (flavonoids/anthocyanins): improved (significantly reduced SUA levels)
22 Mokgalaboni et al. 2024	meta-analysis · 1,382 participants	Curcumin supplementation (form not specified); vs. Placebo	Fasting blood glucose: improved (MD = -11.48 mg/dL, 95%CI (-14.26, -8.70), p < 0.01); Glycated hemoglobin: improved (MD = -0.54%, 95%CI (-0.73, -0.35), p < 0.01)
23 Bahari et al. 2026	systematic review · 1,303 participants	Curcumin/turmeric supplementation; vs. Placebo or control	Serum creatinine: no difference (WMD: -0.01 mg/dL, 95% CI: -0.03 to 0.01, p = 0.519); Blood urea nitrogen (BUN): no difference (WMD: -0.41 mg/dL, 95% CI: -3.15 to 2.33, p = 0.769); Uric acid: unclear (WMD: -1.46 mg/dL, 95% CI: -2.93 to 0.02, p = 0.053)

Further studies in this area: 32 34 39 40 42 43 44 45 47 58 59 60 64 65 67 68 69 70 71 73 74 75 76 81 86 87 92 98 106 110 111 112 118 125 134 135 137 138 139 140 143 145 146 147 148 151 157 161 162 164 165 168 169 170 172 173 174 176 177 178 179 180 181 183 187 189 191 192 194 197 199 200 205 208 209 214 216 219 220 221 222 224 226 235 239 240 243 244 245 246 247 252 254 256 258 262 264 265 270 273 276 277 281 284 285 291 294 307 308 309 316 322 324 326 327 331 338 345 364 366 368 369

Turmeric and Curcumin and Inflammation-Related Conditions: Human Studies

In inflammation-related complaints, curcumin showed improvements in C-reactive protein in several controlled studies and meta-analyses 4 5 15 22 39 53. Tumor necrosis factor-alpha, a messenger substance of inflammation, also decreased more strongly than under control in several studies 5 15 39 111 112 159. Likewise, the erythrocyte sedimentation rate 53 72 119 190 198 279 and the inflammatory messengers interleukin-6 5 111 112 159 174 and interleukin-1 beta 111 112 174 improved. As an adjunct to periodontal treatment, curcumin lowered the gingival index more strongly than the treatment alone 35 250; in rheumatoid arthritis, the rheumatoid factor decreased more strongly than under control 72 279. A meta-analysis on knee osteoarthritis found no difference from placebo for erythrocyte sedimentation rate and interleukin-6 15. Two further controlled studies also saw no difference in the inflammatory markers 247 323. Curcumin, curcuminoid-rich extracts, turmeric powder, curcumin with piperine, and phytosome forms were investigated. Findings from a meta-analysis of various polyphenols in rheumatoid arthritis cannot be attributed to curcumin alone 7. The findings come predominantly from small to medium-sized studies of varying form, dose, and duration, which limits the informative value.

Study	Design · participants	Preparation · dose · duration · comparison	Result
4 Jafari et al. 2024	meta-analysis · 7,216 participants	Curcuma longa L. (form not specified in abstract); vs. Placebo	C-reactive protein: improved; Glutathione: improved; Superoxide dismutase: improved
5 Naghsh et al. 2023	meta-analysis · 5,870 participants	Curcumin supplementation; vs. Placebo or control	C-reactive protein (CRP): improved (ES = -0.74; 95% CI: -1.11, -0.37, p < 0.001); Interleukin-6 (IL-6): improved (ES = -1.07; 95% CI: -1.71, -0.44, p < 0.001); Tumour necrosis factor α (TNF-α): improved (ES: -1.92, 95% CI: -2.64, -1.19, p < 0.0)
7 Long et al. 2023	meta-analysis · 3,852 participants	Curcumin among 14 other polyphenols (mixture); vs. Placebo or control, pooled across 47 RCTs	C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR): improved; Oxidative stress levels: improved
11 Zeng et al. 2022	meta-analysis · 2,396 participants	Curcumin and Curcuma longa extract; 120 mg to 1500 mg; 4 to 36 weeks; vs. randomized controlled trials (control groups not specified)	inflammation severity: improved
13 Ranneh et al. 2024	systematic review · 1,840 participants	Dietary polyphenol supplementation, including turmeric and curcumin; vs. Control groups of the included RCTs	inflammatory cytokines: improved
15 Hsueh et al. 2025	meta-analysis · 1,705 participants	Curcumin (form not specified); vs. Placebo or control group	C-reactive protein (CRP): improved (SMD = -0.906, 95% CI = -1.543 ~ -0.269, P value = 0.005); Tumor necrosis factor-alpha (TNF-alpha): improved (SMD = -0.921, 95% CI = -1.817 ~ -0.026, P value = 0.044); Erythrocyte sedimentation rate (ESR): no difference (SMD = -0.064, 95% CI = -0.064 ~ 0.541, P value = 0.836)
20 Chen et al. 2025	meta-analysis · 1,463 participants	Dietary supplements including curcumin; vs. Network meta-analysis comparing supplements	Interleukin-22: improved (curcumin reduced IL-22)
22 Mokgalaboni et al. 2024	meta-analysis · 1,382 participants	Curcumin supplementation (form not specified); vs. Placebo	C-Reactive Protein: improved (SMD = -0.59, 95%CI (-1.11, -0.07), p = 0.03)

Further studies in this area: 25 31 35 39 47 52 53 54 55 57 59 66 68 70 72 75 76 81 83 102 107 110 111 112 114 117 118 119 123 139 140 141 145 146 147 153 154 156 159 162 164 165 167 171 172 174 176 177 179 180 185 186 187 188 190 191 195 196 198 200 201 204 205 206 208 209 211 213 216 217 218 219 221 224 228 231 240 241 244 247 250 251 254 256 260 261 262 264 266 269 274 279 287 291 293 294 298 304 307 309 313 314 315 316 318 320 323 325 330 331 333 336 340 350 354 355 356 357 361 362 363 364 368 369 370

Turmeric and Curcumin, Joints and the Musculoskeletal System: Human Studies

In joint and movement complaints, curcumin showed improvements in pain intensity in several controlled studies, predominantly in knee osteoarthritis 11 24 37 53 80 101. WOMAC scores 6 80 101 206 and KOOS pain scores 123 202 also improved more than under placebo. Several controlled studies also found better function scores than in the comparison group 93 229 309 and, in rheumatoid arthritis, lower disease activity 53 72 91 279. After unaccustomed exertion, muscle soreness recovered faster under a turmeric preparation than under placebo, and muscle strength declined less 242. Investigated were predominantly curcuminoid-rich extracts, partly in bioavailability-improved or water-dispersible forms, as well as topical curcumin gel and hydrogenated curcumin 202 229 279 309 333. Two controlled studies found no difference from ibuprofen 104 or paracetamol 336, respectively, in pain and function. Disease activity in rheumatoid arthritis and lupus 52, inflammatory markers and synovitis in knee osteoarthritis 323, and performance tests under curcumin gel 202 remained without difference from the control. The findings come partly from combination preparations with Boswellia serrata, NSAIDs or chondroprotective agents and cannot be attributed to curcumin alone 12 16 17 18. The evidence is strong, but many studies are small and short, the forms and additives are inconsistent, and information on manufacturer funding is largely missing.

Study	Design · participants	Preparation · dose · duration · comparison	Result
6 Zhang et al. 2025	meta-analysis · 4,599 participants	Curcumin as a nutritional supplement; vs. Placebo	WOMAC function: improved; WOMAC pain, stiffness, VAS pain: unclear
7 Long et al. 2023	meta-analysis · 3,852 participants	Curcumin among 14 other polyphenols (mixture); vs. Placebo or control, pooled across 47 RCTs	Disease activity score for 28 joints (DAS28): improved
11 Zeng et al. 2022	meta-analysis · 2,396 participants	Curcumin and Curcuma longa extract; 120 mg to 1500 mg; 4 to 36 weeks; vs. randomized controlled trials (control groups not specified)	pain levels: improved
12 Zhao et al. 2024	meta-analysis · 2,175 participants	Curcumin alone or curcumin plus NSAIDs/chondroprotective agents; vs. placebo, NSAIDs, curcumin+NSAIDs, curcumin+chondroprotective agents	VAS pain score: improved (MD = -1.63, 95% CI: -2.91 to -0.45); total WOMAC score: improved (MD = -18.85, 95% CI: -29.53 to -8.76); use of rescue medication: improved (OR = 0.17, 95% CI: 0.08 to 0.36)
14 Del et al. 2017	meta-analysis · 1,741 participants	Oral herbal medicines, including Curcuma longa; vs. Placebo or control	Pain and physical function: no difference
16 Inprasit et al. 2026	meta-analysis · 1,633 participants	Curcuma longa (CL), Boswellia serrata (BS), and mixed formulation; vs. Placebo or other intervention groups	Pain (VAS): improved (SMD: -2.82; 95 %CI: -5.30 to -0.33); WOMAC pain, stiffness, and knee function: improved
17 Zeng et al. 2021	systematic review · 1,621 participants	Curcuma longa extract and curcumin supplements; Recommended: more than 12 weeks; vs. Placebo, NSAIDs, NSAIDs plus curcumin	VAS pain: improved; WOMAC pain: improved; WOMAC function: improved
18 Wan et al. 2022	systematic review · 1,533 participants	Curcuminoid formulations alone or with conventional therapy; vs. NSAIDs or chondroitin sulfate/glucosamine alone	VAS pain: no difference; total WOMAC score: no difference; WOMAC pain/stiffness/physical function: no difference

Further studies in this area: 24 27 29 30 31 36 37 38 52 53 61 72 76 77 79 80 90 91 93 97 99 100 101 104 108 109 115 116 117 122 123 141 142 143 149 153 154 160 163 171 179 188 201 202 206 219 225 229 232 234 242 245 256 275 279 280 285 287 293 309 323 328 333 336 337 343 347 348 353 370 372

Turmeric and Curcumin and Absorption in the Body: Human Studies

Specially prepared forms improved absorption in several controlled studies: micellar, water-soluble, and newly developed preparations achieved higher systemic exposure than conventional curcumin or standard extract 278 294 299. The peak plasma concentrations were also higher with these preparations 278 294 299. Curcumin packaged in fat or water particles (liposomal, nanoemulsified, micellar) was measurable in the blood 233 245 247. An overview mainly of animal and laboratory studies suggests that curcumin is better absorbed in tiny carrier particles (nanocarriers). The findings apply to the respective form investigated — curcuminoid-rich extracts, phytosome and micellar preparations, and ground turmeric rhizome powder — and not to curcumin in general. No difference was found in free curcuminoids between five preparations, between piperine combination and standard extract 271, or in plasma levels after three doses of turmeric powder 305. Most studies were small and investigated healthy volunteers over a short period; the informative value is therefore limited despite the high number of controlled studies.

Study	Design · participants	Preparation · dose · duration · comparison	Result
73 Al-Makhmari et al. 2025	systematic review	Curcumin (Curcuma longa), form and dose not reported; vs. other herbs and controls, not detailed	bioavailability: unclear (its bioavailability remains a challenge)
79 Sato et al. 2025	systematic review	Curcumin or natural derivatives in nanocarrier systems; vs. Free curcumin versus encapsulated curcumin	Solubility, bioavailability and stability: improved
116 Bhat et al. 2023	randomised controlled · 200 participants	Oral curcumin 1 g with piperine 5 mg; 1 g curcumin plus 5 mg piperine twice daily; 52 weeks; vs. Placebo, concurrent csDMARD tapering	Correlation of serum curcuminoid levels with flares: no difference (adjusted HR = 0.99 (95% CI: 0.97-1.0))
126 Wightman et al. 2023	randomised controlled · 128 participants	Multi-ingredient herbal supplement with turmeric whole powder and Turmeric Wholistic™ extract; 90 days (12 weeks); vs. Placebo, randomized, parallel groups	tyrosine in urinary metabolome: improved
153 Majumdar et al. 2025	randomised controlled · 90 participants	CL20192 capsule: Boswellia serrata and Curcuma longa extracts; 300 mg once daily; 90 days; vs. Placebo capsule	Serum levels of boswellic acids and curcuminoids: improved
158 Panahi et al. 2016	randomised controlled · 89 participants	Curcuminoids (1500 mg/day) plus piperine (15 mg/day); 1500 mg curcuminoids + 15 mg piperine daily; 4 weeks; vs. Placebo, double-blind, randomized	Serum GSH levels: improved (p < 0.001); Serum MDA levels: improved (p < 0.001)
162 Azhdari et al. 2026	randomised controlled · 84 participants	Curcumin 500 mg/day, alone or with zinc 30 mg/day; Curcumin 500 mg/day; zinc 30 mg/day; 90 days; vs. Placebo, four groups (curcumin, zinc, curcumin+zinc, placebo)	serum zinc: improved (p=0.001); urinary zinc: improved (p=0.04)
214 Pandaran et al. 2016	randomised controlled · 60 participants	CurQfen (curcumagalactomannoside), natural curcumin with fenugreek fiber; 500 mg twice daily; single dose 500 mg once daily; 30 days; vs. standard curcumin and placebo	free curcuminoids bioavailability, single dose: improved (30.7-fold); free curcuminoids bioavailability, repeated dose: improved (39.1-fold)

Further studies in this area: 233 243 245 247 263 271 274 278 290 292 294 296 297 299 300 301 305 311 318 332 342 346 351 354 357 360 362 364

Turmeric and Curcumin and Digestion: Human Studies

In women with severe obesity, curcumin alleviated gastrointestinal complaints such as belching and constipation more strongly than placebo 265; in children with autism, complaints and fecal calprotectin decreased 198. In ulcerative colitis, a meta-analysis and two reviews of small studies found evidence of a benefit of curcumin, especially as an adjunct to standard therapy 91 94 96. A review saw possible effectiveness in irritable bowel syndrome and chronic inflammatory bowel diseases 85. In irritable bowel syndrome, a meta-analysis found a favorable but not confirmed effect 51, a small randomized study found no difference in gastrointestinal symptoms 291. In hepatic steatosis and liver stiffness, curcumin improved the values in a randomized controlled study 174, and in periodontitis, curcuminoid gel or curcumin gel improved the periodontal parameters 269 304. The findings are based predominantly on small studies of short duration and without information on manufacturer funding; the forms investigated ranged from curcuminoid-rich extract to curcumin with piperine and phytosome form to combination preparations with other substances. Findings from combination preparations are not due to curcumin alone: an herbal preparation with turmeric lowered Sutterella and constipation 126, curcumin with piperine the NAFLD severity 173, a curcumin-boswellia phytosome bloating and abdominal pain 189.

Study	Design · participants	Preparation · dose · duration · comparison	Result
51 Ng et al. 2018	meta-analysis · 326 participants	Curcumin (preparation not specified); vs. Control group in randomized controlled trials	IBS symptom severity from baseline: no difference (pooled standardized mean difference from baseline IBS severity rating -0.466, 95% CI: -1.113 to 0.182, p = 0.158)
85 Thavorn et al. 2024	systematic review	Turmeric (form and curcuminoid content not reported); vs. Randomized controlled trials and comparative observational studies	Efficacy in IBD or IBS: improved; Efficacy in other digestive disorders: unclear
91 Zeng et al. 2022	meta-analysis	Curcumin and Curcuma longa extract; vs. Placebo or control in included RCTs	Clinical or laboratory improvement in ulcerative colitis: improved
94 Coelho et al. 2020	systematic review	Curcumin as complementary therapy; vs. Placebo-controlled RCTs	Maintenance of remission in ulcerative colitis: improved; Remission in Crohn's disease: unclear
96 Holleran et al. 2020	systematic review	Curcumin as a herbal medicine; vs. Placebo in double-blind randomised controlled trials	Evidence of efficacy in ulcerative colitis: improved
126 Wightman et al. 2023	randomised controlled · 128 participants	Multi-ingredient herbal supplement with turmeric whole powder and Turmeric Wholistic™ extract; 90 days (12 weeks); vs. Placebo, randomized, parallel groups	Sutterella in gut microbiome and constipation: improved
173 Mirhafez et al. 2021	randomised controlled · 79 participants	Curcumin plus piperine; 500 mg/day curcumin; 2 months; vs. Placebo, both groups received diet and exercise advice	NAFLD severity: improved (p = 0.04)
174 Yaikwawong et al. 2025	randomised controlled · 78 participants	Curcumin (bioactive polyphenol from turmeric); 1500 mg/day; 12 months; vs. placebo, randomized, double-blind	hepatic steatosis: improved; liver stiffness: improved

Further studies in this area: 189 198 265 269 291 302 304 308 314 341 359

Turmeric and Curcumin, Tolerability and Safety: Human Studies

In this area, 13 controlled studies and 2 meta-analyses with a total of 1732 participants were evaluated for the tolerability of turmeric and curcumin. Several controlled studies and reviews described curcuminoids, curcumin in phytosome form and hydrogenated curcuminoids as well tolerated 85 89 159 228 279. Liver and kidney values remained unremarkable under curcumin 110, liver enzymes remained unchanged under micellar curcuminoids 247, and laboratory values as well as vital signs did not differ from placebo 203. Meta-analyses and reviews found no increase in adverse events under curcumin 6 50 51 93; in a large randomized study over two years, side effects were rare and mild 103. A meta-analysis on curcumin and Curcuma longa extract in various forms of arthritis found no differences in safety endpoints 11. A meta-analysis on Curcuma longa, also as a mixture with Boswellia serrata, found no differences in adverse events 16. A systematic review on Curcuma longa extract and curcumin, partly as a mixture with NSAIDs, reported no differences in adverse events compared with placebo 17. A systematic review found no differences between curcuminoid formulations and NSAIDs in satisfaction, treatment adherence and rescue medication 18. The findings apply to the forms studied — powder, extract, phytosome form and individual substances — and, because of the mostly short study duration and the heterogeneous preparations, can be transferred to long-term use only to a limited extent.

Study	Design · participants	Preparation · dose · duration · comparison	Result
6 Zhang et al. 2025	meta-analysis · 4,599 participants	Curcumin as a nutritional supplement; vs. Placebo	Adverse events
7 Long et al. 2023	meta-analysis · 3,852 participants	Curcumin among 14 other polyphenols (mixture); vs. Placebo or control, pooled across 47 RCTs	Adverse events
9 Gutsche et al. 2025	systematic review · 2,580 participants	Curcumin as complementary therapy, topical or systemic; vs. Control groups of included RCTs	Vomiting: worsened
11 Zeng et al. 2022	meta-analysis · 2,396 participants	Curcumin and Curcuma longa extract; 120 mg to 1500 mg; 4 to 36 weeks; vs. randomized controlled trials (control groups not specified)	safety
12 Zhao et al. 2024	meta-analysis · 2,175 participants	Curcumin alone or curcumin plus NSAIDs/chondroprotective agents; vs. placebo, NSAIDs, curcumin+NSAIDs, curcumin+chondroprotective agents	incidence of adverse reactions (OR = 0.51, 95% CI: 0.25 to 0.94)
16 Inprasit et al. 2026	meta-analysis · 1,633 participants	Curcuma longa (CL), Boswellia serrata (BS), and mixed formulation; vs. Placebo or other intervention groups	Adverse events
17 Zeng et al. 2021	systematic review · 1,621 participants	Curcuma longa extract and curcumin supplements; Recommended: more than 12 weeks; vs. Placebo, NSAIDs, NSAIDs plus curcumin	Adverse events vs. placebo; Adverse events vs. NSAIDs; Adverse events with curcumin plus NSAIDs
18 Wan et al. 2022	systematic review · 1,533 participants	Curcuminoid formulations alone or with conventional therapy; vs. NSAIDs or chondroitin sulfate/glucosamine alone	satisfaction index, global assessment, compliance, rescue medication: no difference

Further studies in this area: 21 24 29 33 38 49 50 51 59 77 78 85 89 90 93 94 99 102 103 104 110 115 116 117 120 122 123 125 129 133 135 142 150 151 152 153 154 159 161 163 175 180 182 185 196 202 203 206 208 209 210 224 225 228 229 232 233 234 236 245 247 248 258 263 268 271 274 275 278 279 282 283 284 285 288 289 290 296 297 301 303 306 309 328 333 336 337 347 348 349 350 351 352 361 362 370

Turmeric and Curcumin: Further Outcomes in Studies

For cognition, several studies found improvements 46 49 57 129 170, while individual controlled studies showed no difference 49 263. For depression 26 50 56 112 244 and anxiety 26 50, several studies also found improvements. The forms ranged from turmeric powder to phytosome; mixed preparations with resveratrol or green tea extract cannot be attributed to curcumin alone 13. The robustness is overall high, but the heterogeneity of the preparations, formulations and endpoints does not allow a uniform statement; it remains open which form and which curcuminoid content are effective for which endpoint.

Study	Design · participants	Preparation · dose · duration · comparison	Result
1 An et al. 2022	meta-analysis · 883,627 participants	Curcumin as micronutrient supplement; vs. Placebo or control	Cardiovascular risk factors: improved (moderate- to high-quality evidence for reducing CVD risk factors)
9 Gutsche et al. 2025	systematic review · 2,580 participants	Curcumin as complementary therapy, topical or systemic; vs. Control groups of included RCTs	Oral mucositis: improved; Weight loss: improved; Oral and skin symptoms, pain, body composition, survival, disease progression: unclear
10 Zeng et al. 2025	meta-analysis · 2,481 participants	Nanocurcumin compared with other nutritional supplements; vs. other supplements, e.g. BSO, probiotics, vitamin D	FEV1% (lung function): improved (MD=13, 95% CI (7.7, 18)); FEV1/FVC: improved (MD=12, 95% CI (4.6, 19), p<0.05)
13 Ranneh et al. 2024	systematic review · 1,840 participants	Dietary polyphenol supplementation, including turmeric and curcumin; vs. Control groups of the included RCTs	NAFLD score: improved
18 Wan et al. 2022	systematic review · 1,533 participants	Curcuminoid formulations alone or with conventional therapy; vs. NSAIDs or chondroitin sulfate/glucosamine alone	Karnofsky Performance Scale score vs. chondroitin sulfate/glucosamine: no difference
21 Sawangjit et al. 2025	meta-analysis · 1,407 participants	Turmeric, mostly nano-curcumin, as adjunct to standard care; Nano-curcumin 160-240 mg/day; vs. Placebo or standard care	All-cause mortality: improved (RR = 0.39; 95 % CI: 0.23-0.67); Need for intubation/mechanical ventilation: improved (RR = 0.35; 95 % CI: 0.17-0.72); Clinical deterioration: improved (RR=0.36; 95 % CI: 0.22-0.59)
25 Indriyani et al. 2025	systematic review · 1,244 participants	Curcumin, various formulations; vs. randomized controlled trials (control not specified)	antioxidant, collagenase-inhibiting, antifungal and wound-healing properties: improved
26 Yuan et al. 2025	systematic review · 1,123 participants	Curcumin from Curcuma longa, various formulations; varied, not reported in abstract; vs. placebo or control	Depressive symptoms (SMD): improved (SMD: -0.65, P = 0.01, 95% CI: -1.16 to -0.13); Anxiety symptoms (SMD): improved (SMD: -0.22, P = 0.01, 95% CI: -0.40 to -0.05)

Further studies in this area: 28 32 41 44 45 46 47 48 49 50 54 56 57 59 62 63 66 70 75 76 78 81 82 83 84 88 89 91 95 102 103 105 107 112 113 114 120 121 122 124 126 127 128 129 130 131 132 133 136 142 143 144 149 150 151 152 153 155 158 159 164 165 166 168 170 175 176 179 181 182 184 185 187 189 190 191 193 196 198 199 200 201 205 207 208 209 210 212 213 214 215 216 219 220 221 223 224 227 228 229 230 237 238 239 240 241 244 246 248 249 251 253 254 255 256 257 259 261 263 267 268 272 273 274 280 281 282 283 284 285 286 287 288 289 293 295 303 305 306 307 310 312 313 314 317 318 319 321 322 325 327 329 334 335 339 344 347 348 349 350 351 353 354 355 356 357 358 360 361 362 363 365 367 371 373

4. How Is Turmeric and Curcumin Dosed? Preparation, Dose and Duration in Studies

The studies used ground turmeric rhizome powder, curcuminoid-rich extracts, curcumin with piperine from black pepper, curcumin in phytosome form as well as individual curcuminoids and hydrogenated curcumin. Some of the investigations tested mixed preparations with other polyphenols, Boswellia serrata or NSAIDs, whose findings cannot be attributed to curcumin alone. Form, curcuminoid content and duration of administration were not precisely stated in many studies.

Preparation or form	Dose	Duration	Study
oral curcumin (turmeric extract, exact composition not stated)	2000 mg per dose, 8 doses over 4 days	4 days perioperative	102
Oral submicron-powdered curcumin (Theracurmin®)	180 mg twice daily	2 years	103
Curcuma domestica extract (1,500 mg/day)	1,500 mg/day	4 weeks	104
commercially available curcumin 500 mg orally	500 mg curcumin daily	90 days treatment, then 3 months post-treatment follow-up	105
Curcumin extract (Curcuma longa)	1500 mg/day	12 months	106
SinaCurcumin™ nano-curcumin	240 mg daily	3 days pre-op plus 4 post-op days	107
turmeric-Boswellia extract (TBE), 1,000 mg	1,000 mg TBE	6 hours	108
TBF (Rhuleave-K): turmeric and boswellia extracts in sesame oil	single dose of 1000 mg TBF	single dose, follow-up up to 6 hours	109
Curcumin 1500 mg daily	1500 mg/day	12 months	110
Curcumin (from turmeric root)	—	12 months	111
Curcumin supplement	—	12 months	112
PMSoff supplement containing turmeric among 11 ingredients	—	2 months	113
BV-4051, Ayurvedic polyherbal tablet with Ashwagandha, Boswellia, Ginger and Turmeric	—	14 days	114
CuraMed (curcuminoid extract with turmeric oil) or Curamin (plus boswellic acid)	500 mg capsule three times daily (333 mg curcuminoids; 350 mg curcuminoids + 150 mg boswellic acid)	12 weeks	115
Oral curcumin 1 g with piperine 5 mg	1 g curcumin plus 5 mg piperine twice daily	52 weeks	116

5. Is Turmeric and Curcumin Safe? Side Effects in Studies

Curcumin was well tolerated in most studies 50 89 159 228. Under a Curcuma domestica extract, abdominal pain occurred less often than under ibuprofen 104, other studies reported more gastrointestinal complaints under curcumin 9 49 263 275. As an infusion, liposomal curcumin temporarily changed the shape of red blood cells at higher doses 233.

Study	Reported side effects
6 Zhang et al. 2025	No increase in adverse events versus placebo
7 Long et al. 2023	Adding polyphenols did not increase adverse events
9 Gutsche et al. 2025	One study reported significantly more vomiting in the curcumin group
11 Zeng et al. 2022	Safe in all studies; no further details
12 Zhao et al. 2024	curcumin and curcumin+NSAIDs reduced adverse reactions versus NSAIDs
14 Del et al. 2017	Adverse events as secondary outcome, no numbers reported
16 Inprasit et al. 2026	No significant differences in adverse events across all comparisons
17 Zeng et al. 2021	Comparable to placebo; lower than NSAIDs; adding to NSAIDs did not increase events
18 Wan et al. 2022	Curcuminoid formulations could alleviate some adverse events caused by NSAIDs
20 Chen et al. 2025	Adverse events comparable (RR 1.02, 95% CI 0.94–1.10)
21 Sawangjit et al. 2025	Mostly mild gastrointestinal symptoms, comparable to placebo
24 Hsiao et al. 2021	Higher AE rates with NSAIDs, significant in only one study

6. What Remains Open: Limits of the Evidence

Many studies are small and short, and form, curcuminoid content as well as duration of administration are often not precisely stated.
Information on manufacturer funding is largely missing, which makes it difficult to assess the findings.
The bioavailability of conventional curcumin is low; the absorption findings apply only to the specific form investigated in each case.
Findings from mixed preparations with other polyphenols, Boswellia serrata or NSAIDs cannot be attributed to curcumin alone.
It remains open which form and which curcuminoid content are effective for which endpoint.

7. Bottom Line: What Is Established About Turmeric and Curcumin

Turmeric and curcumin have been investigated in numerous controlled human studies and meta-analyses. Improvements are seen in metabolic and blood values, in inflammation-related complaints, in joint and movement complaints as well as in digestive complaints. Specially prepared forms such as micellar and water-soluble preparations increased the absorption of curcuminoids compared with conventional curcumin in small studies. Tolerability was good in most studies, although gastrointestinal side effects occurred more frequently in individual studies.

The validity is limited by the fact that many studies are small and short, form and curcuminoid content remain inconsistent and information on manufacturer funding is largely missing. Individual endpoints remained without difference, and a randomised controlled study in healthy older people found elevated blood glucose under curcumin. Findings from mixed preparations cannot be attributed to curcumin alone.

Frequently Asked Questions

How well has Turmeric and Curcumin been studied in humans?

Does Turmeric and Curcumin help with metabolism and blood values? What the studies show

We evaluated 24 meta-analyses or systematic reviews, 90 controlled studies and 16 further studies; the controlled studies include 5,919 participants in total. Result of the controlled studies: mostly improved. Strength of evidence under our published rules: high. Sources: 2 3 4 8

Does Turmeric and Curcumin help with inflammation-related conditions? What the studies show

We evaluated 17 meta-analyses or systematic reviews, 94 controlled studies and 22 further studies; the controlled studies include 6,429 participants in total. Result of the controlled studies: mostly improved. Strength of evidence under our published rules: high. Sources: 4 5 7 11

Does Turmeric and Curcumin help with joints and the musculoskeletal system? What the studies show

We evaluated 16 meta-analyses or systematic reviews, 43 controlled studies and 20 further studies; the controlled studies include 3,339 participants in total. Result of the controlled studies: mostly improved. Strength of evidence under our published rules: high. Sources: 6 7 11 12

Does Turmeric and Curcumin help with absorption in the body? What the studies show

We evaluated one meta-analysis or systematic review, 28 controlled studies and 7 further studies; the controlled studies include 1,077 participants in total. Result of the controlled studies: mostly improved. Strength of evidence under our published rules: high. Sources: 73 79 116 126

Does Turmeric and Curcumin help with digestion? What the studies show

We evaluated 4 meta-analyses or systematic reviews, 13 controlled studies and 2 further studies; the controlled studies include 511 participants in total. Result of the controlled studies: mostly improved. Strength of evidence under our published rules: high. Sources: 51 85 91 94

Does Turmeric and Curcumin help with tolerability and safety? What the studies show

We evaluated 2 meta-analyses or systematic reviews, 13 controlled studies and 89 further studies; the controlled studies include 1,732 participants in total. Result of the controlled studies: mostly no difference. Strength of evidence under our published rules: high. Sources: 6 7 9 11

What is the difference between turmeric and curcumin?

Turmeric is the dried and ground rhizome of Curcuma longa, a plant from the ginger family. Curcumin is the yellow colouring of the rhizome and belongs to the group of curcuminoids. Turmeric traditionally serves as a spice and colouring agent.

Which forms of curcumin were investigated in the studies?

Ground turmeric rhizome powder, curcuminoid-rich extracts, curcumin with piperine from black pepper, curcumin in phytosome form as well as individual curcuminoids and hydrogenated curcumin were investigated. Some of the studies tested mixed preparations with other substances. The absorption findings apply only to the specific form investigated in each case.

How well is curcumin tolerated?

Several controlled studies and reviews described curcuminoids, curcumin in phytosome form and hydrogenated curcuminoids as well tolerated 85 89 159 228 279. Liver and kidney values remained unremarkable 110, the liver enzymes also under micellar curcuminoids 247. For gastrointestinal side effects, the picture was mixed, and due to the mostly short study duration, the findings can only be transferred to long-term use to a limited extent.

Why is the bioavailability of curcumin an issue?

Conventional curcumin is poorly absorbed; micellar and water-soluble preparations achieved significantly higher blood levels in small studies 278 294 299. These findings apply only to the specific form investigated in each case. Most of these studies were small and investigated healthy volunteers over a short period.

Can findings from mixed preparations be transferred to curcumin alone?

No. To make a statement about curcumin alone, studies with the individual substance are necessary.

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Dietary Factors and Supplements Influencing Prostate Specific-Antigen (PSA) Concentrations in Men with Prostate Cancer and Increased Cancer Risk: An Evidence Analysis Review Based on Randomized Controlled Trials
Grammatikopoulou MG, Gkiouras K, Papageorgiou SΤ, Myrogiannis I, Mykoniatis I, Papamitsou T et al. · 2020
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Herbal medicinal products for inflammatory bowel disease: A focus on those assessed in double-blind randomised controlled trials
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Efficacy of Spice Supplementation in Rheumatoid Arthritis: A Systematic Literature Review
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98
Curcumin reduces malondialdehyde and improves antioxidants in humans with diseased conditions: a comprehensive meta-analysis of randomized controlled trials
Alizadeh M, Kheirouri S · 2019
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Dietary supplements for treating osteoarthritis: a systematic review and meta-analysis
Liu X, Machado GC, Eyles JP, Ravi V, Hunter DJ · 2018
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Which supplements can I recommend to my osteoarthritis patients?
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101
Efficacy of Turmeric Extracts and Curcumin for Alleviating the Symptoms of Joint Arthritis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials
Daily JW, Yang M, Park S · 2016
102
Oral curcumin in elective abdominal aortic aneurysm repair: a multicentre randomized controlled trial
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103
Curcumin Suppresses Growth of Recurrent Colorectal Adenoma After Endoscopic Resection: A Randomized, Double-Blind, Placebo-Controlled, Multicenter Trial
Takayama T, Okamoto K, Ishikawa H, Kagemoto K, Yasaka T, Hisabe T et al. · 2026
104
Efficacy and safety of Curcuma domestica extracts compared with ibuprofen in patients with knee osteoarthritis: a multicenter study
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105
A comparative study to evaluate the therapeutic effects of nutraceuticals in oral leukoplakia:- A randomized clinical trail
Ahmad T, Khan I, Sultana A, Rizvi MMA · 2023
106
Curcumin extract improves beta cell functions in obese patients with type 2 diabetes: a randomized controlled trial
Yaikwawong M, Jansarikit L, Jirawatnotai S, Chuengsamarn S · 2024
107
The effect of nanocurcumin on the incidence of atrial fibrillation, and markers of inflammation and oxidative stress level after coronary artery bypass graft surgery: A randomized, double-blind, placebo-controlled clinical study
Hossaini Alhashemi S, Mohammadpour AH, Heidari R, Nikoo MH, Nemati MH, Vazin A · 2022
108
Modulation of Affective and Sensory Qualities of Acute Nociceptive Pain by Curcuma longa and Boswellia serrata Extract Formulation: A Randomized, Double-Blind, Placebo-Controlled Design in Subjects With Exercise-Induced Acute Musculoskeletal Pain
Kumar Kare S, H R G, Gupta A · 2025
109
Fast pain relief in exercise-induced acute musculoskeletal pain by turmeric-boswellia formulation: A randomized placebo-controlled double-blinded multicentre study
Rudrappa GH, Murthy M, Saklecha S, Kumar Kare S, Gupta A, Basu I · 2022
110
Curcumin Attenuates Liver Steatosis via Antioxidant and Anti-Inflammatory Pathways in Obese Patients with Type 2 Diabetes Mellitus: A Randomized Controlled Trial
Yaikwawong M, Kamdee K, Chuengsamarn S · 2025
111
The Effect of Curcumin on Reducing Atherogenic Risks in Obese Patients with Type 2 Diabetes: A Randomized Controlled Trial
Yaikwawong M, Jansarikit L, Jirawatnotai S, Chuengsamarn S · 2024
112
Curcumin Reduces Depression in Obese Patients with Type 2 Diabetes: A Randomized Controlled Trial
Yaikwawong M, Jansarikit L, Jirawatnotai S, Chuengsamarn S · 2024
113
Natural relief for premenstrual syndrome (PMS): a double-blind clinical trial on the efficacy and safety of PMSoff
Saghafi F, Zare P, Hatamizadeh N, Malmir M, Sahebnasagh A · 2025
114
Phase III randomized clinical trial of BV-4051, an Ayurvedic polyherbal formulation in moderate SARS-CoV-2 infections and its impact on inflammatory biomarkers
Chitre D, Nadkarni S, Jagtap N, Tulle R, Gitte A, Rahate P et al. · 2023
115
Efficacy and safety of curcumin and its combination with boswellic acid in osteoarthritis: a comparative, randomized, double-blind, placebo-controlled study
Haroyan A, Mukuchyan V, Mkrtchyan N, Minasyan N, Gasparyan S, Sargsyan A et al. · 2018
116
Efficacy and safety of curcumin in maintaining remission during disease-modifying antirheumatic drug withdrawal in rheumatoid arthritis at 52 weeks: a phase III double-blind, randomized placebo-controlled trial
Bhat SS, Ahmed S, Reji R, Mehta P, Paul A, Mohanan M et al. · 2023
117
Efficacy of a proprietary combination of Tamarindus indica seeds and Curcuma longa rhizome extracts in osteoarthritis: a clinical investigation
Prasad N, Vinay V, Srivastava A · 2023
118
An Evaluation of a Nutraceutical with Berberine, Curcumin, Inositol, Banaba and Chromium Picolinate in Patients with Fasting Dysglycemia
Derosa G, D'Angelo A, Vanelli A, Maffioli P · 2020
119
A Triple-blind randomized controlled trial on the effects of turmeric versus ginger on inflammatory biomarkers in patients with COVID-19
Saleh Z, Asgari MR, Ghorbani R, Babamohamadi H · 2025
120
Safety and efficacy of an add-on therapy with curcumin phytosome and piperine and/or lipoic acid in subjects with a diagnosis of peripheral neuropathy treated with dexibuprofen
Di Pierro F, Settembre R · 2013
121
A new nutraceutical (Livogen Plus®) improves liver steatosis in adults with non-alcoholic fatty liver disease
Ferro Y, Pujia R, Mazza E, Lascala L, Lodari O, Maurotti S et al. · 2022
122
Efficacy and safety of combination of curcuminoid complex and diclofenac versus diclofenac in knee osteoarthritis: A randomized trial
Shep D, Khanwelkar C, Gade P, Karad S · 2020
123
Efficacy and Safety of a Novel Low-Dose Water-Dispersible Turmeric Extract in the Management of Knee Osteoarthritis: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
Thanawala S, Shah R, Alluri KV, Bhupathiraju K, Prasad N, Agarwal Y · 2025
124
Analgesic Efficacy of Bromelain and Bromelain Plus Turmeric for Pain Control After Orthodontic Separator Placement: A Triple-Blind Randomized Clinical Trial
Ajami S, Hosseini SH, Babanouri N, Hashemi Z · 2025
125
Long-term safety and efficacy of a highly purified plant-based nutraceutical for improving clinical parameters of liver function in healthy participants: a randomized, double-blind, placebo-controlled clinical trial
Patel G, Shah S, D'Adamo CR · 2025
126
Chronic supplementation of a multi-ingredient herbal supplement increases speed of cognitive task performance alongside changes in the urinary metabolism of dopamine and the gut microbiome in cognitively intact older adults experiencing subjective memory decline: a randomized, placebo controlled, parallel groups investigation
Wightman E, Khan J, Smith E, Rolfe V, Smith D, Young G et al. · 2023
127
Prevention of Recurrent Benign Paroxysmal Positional Vertigo: The Role of Combined Supplementation with Vitamin D and Antioxidants
Libonati GA, Leone A, Martellucci S, Gallo A, Albera R, Lucisano S et al. · 2022
128
The effect of curcumax on postpartum women's depression: a randomized controlled trial
Nikpour F, Ansari S, Abedi P, Jahanfar S, Sharifat N, Hooshmand G et al. · 2024
129
Efficacy of Curcumin on Cognitive Function Scores in Women with Premenstrual Syndrome and Dysmenorrhea: A Triple-Blind, Placebo-Controlled Clinical Trial
Bahrami A, Jafari-Nozad AM, Karbasi S, Ayadilord M, Ferns GA · 2023
130
Effects of curcumin supplementation on insomnia and daytime sleepiness in young women with premenstrual syndrome and dysmenorrhea: A randomized clinical trial
Seyedabadi S, Hoseini ZS, Ferns GA, Bahrami A · 2023
131
Efficacy of curcumin, and a saffron/curcumin combination for the treatment of major depression: A randomised, double-blind, placebo-controlled study
Lopresti AL, Drummond PD · 2017
132
Biocurcumin as Radiosensitiser for Cervical Cancer Study (BRACES): A Double-Blind Randomised Placebo-Controlled Trial
Purbadi S, Rustamadji P, Prijanti AR, Sekarutami SM, Sutrisna B, Suyatna FD et al. · 2020
133
Efficacy and Safety of Curcumin as an Adjuvant to Standard Chemotherapy in Advanced and Metastatic Breast Cancer Patients: A Randomized Controlled Study
Goyal S, Beniwal SK, Agarwal P, Brar RK, Jain P, Kumar HS et al. · 2025
134
The Efficacy of Nigella sativa L. and Curcumin Nanomicelle Alone or Together on Lipid Profile, Glycemic Control Indices, and Serum 17-Β Estradiol in Postmenopausal Women
Sadeghzadeh Z, Ostadrahimi A, Ranjbar M, Farshbaf-Khalili A · 2023
135
Efficacy of nanomicelle curcumin, Nigella sativa oil, and their combination on bone turnover markers and their safety in postmenopausal women with primary osteoporosis and osteopenia: A triple-blind randomized controlled trial
Kheiridoost H, Shakouri SK, Shojaei-Zarghani S, Dolatkhah N, Farshbaf-Khalili A · 2022
136
The effect of nanomicelle curcumin supplementation and Nigella sativa oil on the expression level of miRNA-21, miRNA-422a, and miRNA-503 gene in postmenopausal women with low bone mass density: A randomized, triple-blind, placebo-controlled clinical trial with factorial design
Farshbaf-Khalili A, Farajnia S, Pourzeinali S, Shakouri SK, Salehi-Pourmehr H · 2021
137
Antioxidant effects of curcuminoids in patients with type 2 diabetes mellitus: a randomized controlled trial
Panahi Y, Khalili N, Sahebi E, Namazi S, Karimian MS, Majeed M et al. · 2017
138
Curcuminoids modify lipid profile in type 2 diabetes mellitus: A randomized controlled trial
Panahi Y, Khalili N, Sahebi E, Namazi S, Reiner Ž, Majeed M et al. · 2017
139
Antioxidant and anti-inflammatory effects of curcuminoid-piperine combination in subjects with metabolic syndrome: A randomized controlled trial and an updated meta-analysis
Panahi Y, Hosseini MS, Khalili N, Naimi E, Majeed M, Sahebkar A · 2015
140
Curcumin Supplementation Reduces Inflammation, Neutrophil-to-Lymphocyte Ratio (NLR), and Antioxidant Status in Obese Patients with Type 2 Diabetes: A Randomized Controlled Trial
Yaikwawong M, Kamdee K, Chuengsamarn S · 2026
141
A full-spectrum Boswellia serrata extract with enhanced bioavailability, and its co-delivered system with curcumin alleviate pain and stiffness associated with moderate spondylitis: a randomized double-blind, placebo-controlled, 3-arm study
Mamatha K, Prabhakaran P, Syam Das S, Kanjoormana Aryan M, Thomas J · 2025
142
A Placebo-Controlled Double-Blind Study Demonstrates the Clinical Efficacy of a Novel Herbal Formulation for Relieving Joint Discomfort in Human Subjects with Osteoarthritis of Knee
Karlapudi V, Prasad Mungara AVV, Sengupta K, Davis BA, Raychaudhuri SP · 2018
143
Curcumin supplementation during high-altitude exposure modulates body composition and its relationship with gut microbiota: a randomized controlled trial
Hu J, Fan D, Xiao C, Kang C, Shi J, Li Y et al. · 2026
144
Adjunctive curcumin nano-micelles reduce overall pruritus intensity in refractory post-burn pruritus: A randomized controlled trial
Alirezaei L, Golmohammadi H, Pourrashid MH, Kheiri AA, Sarbakhsh P, Samankan S et al. · 2025
145
A minor metabolite from Curcuma longa effective against metabolic syndrome: results from a randomized, double-blind, placebo-controlled clinical study
Majeed M, Nagabhushanam K, Devarajan TV, Saklecha S, Reddy SVK, Mundkur L · 2023
146
Effects of Curcuminoids Plus Piperine on Glycemic, Hepatic and Inflammatory Biomarkers in Patients with Type 2 Diabetes Mellitus: A Randomized Double-Blind Placebo-Controlled Trial
Panahi Y, Khalili N, Sahebi E, Namazi S, Simental-Mendía LE, Majeed M et al. · 2018
147
Curcuminoids Plus Piperine Modulate Adipokines in Type 2 Diabetes Mellitus
Panahi Y, Khalili N, Sahebi E, Namazi S, Atkin SL, Majeed M et al. · 2017
148
Lipid-modifying effects of adjunctive therapy with curcuminoids-piperine combination in patients with metabolic syndrome: results of a randomized controlled trial
Panahi Y, Khalili N, Hosseini MS, Abbasinazari M, Sahebkar A · 2014
149
A commercialized dietary supplement alleviates joint pain in community adults: a double-blind, placebo-controlled community trial
Nieman DC, Shanely RA, Luo B, Dew D, Meaney MP, Sha W · 2013
150
Efficacy of Curcuminoids in Managing Postoperative Pain after Total Laparoscopic Hysterectomy: A Randomized Controlled, Open-Label Trial
Ariyasriwatana C, Phoolcharoen N, Oranratanaphan S, Worasethsin P · 2022
151
The effectiveness and safety of nanocurcumin supplementation for diabetic peripheral neuropathy in patients with type 2 diabetes: a randomized double-blind clinical trial
Mansour A, Rahimi HR, Gerami H, Khorasanian AS, Esmaeili AH, Amrollahi Bioky A et al. · 2025
152
Efficacy and Safety of an Oral Low-Dose Water-Dispersible Turmeric Extract Capsule on Facial Skin Health in Healthy Women: A Randomized, Double-Blind, Placebo-Controlled Trial
Thanawala S, Shah R, Alluri KV, Bhupathiraju K, Salvi A · 2025
153
Efficacy and safety evaluation of Boswellia serrata and Curcuma longa extract combination in the management of chronic lower back pain: A randomised, double-blind, placebo-controlled clinical study
Majumdar A, Prasad MAVV, Gandavarapu SR, Reddy KSK, Sureja V, Kheni D et al. · 2025
154
Tamarindus indica Seed Extract-Based Botanical Compositions Alleviate Knee Pain and Improve Joint Function in Mild-to-Moderate Osteoarthritis: A Randomized, Double-Blind, Placebo-Controlled Clinical Study
Kare SK, Vinay V, Maresz K, Prisk V, Vik H · 2022
155
Comparison of therapeutic response of lycopene and curcumin in oral submucous fibrosis: A randomized controlled trial
Piyush P, Mahajan A, Singh K, Ghosh S, Gupta S · 2019
156
The efficacy of curcumin in managing acute inflammation pain on the post-surgical removal of impacted third molars patients: A randomised controlled trial
Maulina T, Diana H, Cahyanto A, Amaliya A · 2018
157
Cost-Effectiveness of Passion Fruit Albedo versus Turmeric in the Glycemic and Lipaemic Control of People with Type 2 Diabetes: Randomized Clinical Trial
Sousa DF, Araújo MFM, de Mello VD, Damasceno MMC, Freitas RWJF · 2021
158
Effects of Curcuminoids-Piperine Combination on Systemic Oxidative Stress, Clinical Symptoms and Quality of Life in Subjects with Chronic Pulmonary Complications Due to Sulfur Mustard: A Randomized Controlled Trial
Panahi Y, Ghanei M, Hajhashemi A, Sahebkar A · 2016
159
Short-term Curcuminoid Supplementation for Chronic Pulmonary Complications due to Sulfur Mustard Intoxication: Positive Results of a Randomized Double-blind Placebo-controlled Trial
Panahi Y, Ghanei M, Bashiri S, Hajihashemi A, Sahebkar A · 2015
160
Efficacy of high-dissolution turmeric-sesame formulation for pain relief in adult subjects with acute musculoskeletal pain compared to acetaminophen: A randomized controlled study
Rudrappa GH, Chakravarthi PT, Benny IR · 2020
161
Efficacy and Safety of a Multi-Ingredient Liquid-Based Botanical Nutraceutical for Improving Markers of Metabolic Health: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
Messier H, D'Adamo CR, Panchal N, Patel G · 2026
162
Combined Effects of Curcumin and Zinc Co-Supplementation on Inflammatory and Oxidative Stress Biomarkers in Prediabetes: A Double-Blind, Randomized, Placebo- Controlled Trial
Azhdari M, Karandish M, Mozaffari-khosravi H, Cheraghian B, Mohammadi SM · 2026
163
Effect of an oral complementary medicine combination for symptomatic knee osteoarthritis: A double-blind, randomized, placebo-controlled trial
Yuan S, Liu X, Bracken K, Christensen R, Deveza LA, Collins S et al. · 2026
164
Nano-curcumin improves glucose indices, lipids, inflammation, and Nesfatin in overweight and obese patients with non-alcoholic fatty liver disease (NAFLD): a double-blind randomized placebo-controlled clinical trial
Jazayeri-Tehrani SA, Rezayat SM, Mansouri S, Qorbani M, Alavian SM, Daneshi-Maskooni M et al. · 2019
165
Evaluation of the effectiveness of curcumin and piperine co-supplementation on inflammatory factors, cardiac biomarkers, atrial fibrillation, and clinical outcomes after coronary artery bypass graft surgery
Tehrani SD, Hosseini A, Shahzamani M, Heidari Z, Askari G, Majeed M et al. · 2024
166
Curcuminoid-Piperine Combination Improves Radical Scavenging Activity in Women with Premenstrual Syndrome and Dysmenorrhea: A Post-hoc Analysis of a Randomized Clinical Study
Karbasi S, Seyedabadi S, Mozaffari S, Foroutan Z, Ferns GA, Zarban A et al. · 2024
167
Effects of curcumin-piperine supplementation on systemic immunity in young women with premenstrual syndrome and dysmenorrhea: A randomized clinical trial
Bahrami A, Mohammadifard M, Rajabi Z, Motahari-Nasab M, Ferns GA · 2022
168
The Effect of Curcumin Phytosome on the Treatment of Patients with Non-alcoholic Fatty Liver Disease: A Double-Blind, Randomized, Placebo-Controlled Trial
Mirhafez SR, Azimi-Nezhad M, Dehabeh M, Hariri M, Naderan RD, Movahedi A et al. · 2021
169
Effects of phytosomal curcumin on anthropometric parameters, insulin resistance, cortisolemia and non-alcoholic fatty liver disease indices: a double-blind, placebo-controlled clinical trial
Cicero AFG, Sahebkar A, Fogacci F, Bove M, Giovannini M, Borghi C · 2020
170
Further Evidence of Benefits to Mood and Working Memory from Lipidated Curcumin in Healthy Older People: A 12-Week, Double-Blind, Placebo-Controlled, Partial Replication Study
Cox KHM, White DJ, Pipingas A, Poorun K, Scholey A · 2020
171
Curcumagalactomannoside/Glucosamine Combination Improved Joint Health Among Osteoarthritic Subjects as Compared to Chondroitin Sulfate/Glucosamine: Double-Blinded, Randomized Controlled Study
Khanna A, Das SS, Smina TP, Thomas JV, Kunnumakkara AB, Maliakel B et al. · 2020
172
Effects on oral fat load of a nutraceutical combination of fermented red rice, sterol esters and stanols, curcumin, and olive polyphenols: A randomized, placebo controlled trial
Derosa G, Catena G, Raddino R, Gaudio G, Maggi A, D'Angelo A et al. · 2018
173
Curcumin and Piperine Combination for the Treatment of Patients with Non-alcoholic Fatty Liver Disease: A Double-Blind Randomized Placebo-Controlled Trial
Mirhafez SR, Dehabeh M, Hariri M, Farimani AR, Movahedi A, Naderan RD et al. · 2021
174
Curcumin for Inflammation Control in Individuals with Type 2 Diabetes Mellitus and Metabolic Dysfunction-Associated Steatotic Liver Disease: A Randomized Controlled Trial
Yaikwawong M, Jansarikit L, Jirawatnotai S, Chuengsamarn S · 2025
175
The effect of adding curcumin to sodium valproate in treatment of patients with bipolar disorder in the acute phase of mania: A randomized double-blind clinical trial
Akbarzadeh F, Niksun N, Behravan G, Behdani F, Mohammadpour AH, Jaafari M et al. · 2023
176
Curcuma longa improves endothelial glycocalyx integrity and redox-inflammatory pathways in type 2 diabetes mellitus: a randomized double-blind placebo-controlled study
Viudes DR, Mateus AR, Silva CA, do Carmo Franco M · 2026
177
Effect of curcumin on inflammatory biomarkers and iron profile in patients with premenstrual syndrome and dysmenorrhea: A randomized controlled trial
Talebpour A, Mohammadifard M, Zare Feyzabadi R, Mahmoudzadeh S, Rezapour H, Saharkhiz M et al. · 2023
178
Effects of curcumin supplementation on vitamin D levels in women with premenstrual syndrome and dysmenorrhea: a randomized controlled study
Arabnezhad L, Mohammadifard M, Rahmani L, Majidi Z, Ferns GA, Bahrami A · 2022
179
The effect of curcumin-piperine supplementation on lipid profile, glycemic index, inflammation, and blood pressure in patients with type 2 diabetes mellitus and hypertriglyceridemia
Hosseini H, Bagherniya M, Sahebkar A, Iraj B, Majeed M, Askari G · 2024
180
A scientifically validated combination of garcinol, curcuminoids, and piperine for mild to moderate nonalcoholic steatohepatitis patients-results from a randomized, double-blind, placebo-controlled study
Majeed M, Nagabhushanam K, Noureddin M, Paulose S, Barik C, Saklecha S et al. · 2023
181
The Effects of Curcumin Plus Piperine Supplementation in Patients with Acute Myocardial Infarction: A Randomized, Double-Blind, and Placebo-Controlled Trial
Tabaee S, Sahebkar A, Aghamohammadi T, Pakdel M, Dehabeh M, Sobhani R et al. · 2021
182
Effectiveness of a novel herbal agent MB-6 as a potential adjunct to 5-fluoracil-based chemotherapy in colorectal cancer
Chen WT, Yang TS, Chen HC, Chen HH, Chiang HC, Lin TC et al. · 2014
183
Effectiveness of the piperine-supplemented Curcuma longa L. in metabolic control of patients with type 2 diabetes: a randomised double-blind placebo-controlled clinical trial
Neta JFF, Veras VS, Sousa DF, Cunha MDCDSO, Queiroz MVO, Neto JCGL et al. · 2021
184
Curcumin as a neuroprotective agent against platinum-induced peripheral neuropathy: a double-blind randomized clinical trial
Zabihi M, Hoseinzadeh F, Mostafaei M, Vahedian-Ardakani HA, Saghafi F · 2026
185
Effectiveness of curcumin mouthwash in preventing traumatic ulcers in orthodontic patients
Somprajob C, Auychai P, Chavanavesh J, Suttamanatwong S · 2025
186
The effects of nanomicelle of curcumin on the matrix metalloproteinase (MMP-2, 9) activity and expression in patients with coronary artery disease (CAD): A randomized controlled clinical trial
Mogharrabi M, Rahimi HR, Hasanzadeh S, Dastani M, Kazemi-Oskuee R, Akhlaghi S et al. · 2020
187
Curcuminoids plus piperine improve nonalcoholic fatty liver disease: A clinical trial
Panahi Y, Valizadegan G, Ahamdi N, Ganjali S, Majeed M, Sahebkar A · 2019
188
Acute Effects of Turmeric Extracts on Knee Joint Pain: A Pilot, Randomized Controlled Trial
Calderón-Pérez L, Llauradó E, Companys J, Pla-Pagà L, Boqué N, Puiggrós F et al. · 2021
189
Beneficial Effects on Abdominal Bloating with an Innovative Food-Grade Formulation of Curcuma longa and Boswellia serrata Extracts in Subjects with Irritable Bowel Syndrome and Small Bowel Dysbiosis
Giacosa A, Riva A, Petrangolini G, Allegrini P, Fazia T, Bernardinelli L et al. · 2022
190
Effects of Curcuminoids on Systemic Inflammation and Quality of Life in Patients with Colorectal Cancer Undergoing Chemotherapy: A Randomized Controlled Trial
Panahi Y, Saberi-Karimian M, Valizadeh O, Behnam B, Saadat A, Jamialahmadi T et al. · 2021
191
Therapeutic effects of curcumin and piperine combination in critically ill patients with sepsis: a randomized double-blind controlled trial
Alikiaii B, Khatib N, Badpeyma M, Hasanzadeh E, Abbasi S, Amini S et al. · 2025
192
The Effect of Curcumin Supplementation on Pulse Wave Velocity in Patients with Metabolic Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial
Alidadi M, Sahebkar A, Eslami S, Vakilian F, Jarahi L, Alinezhad-Namaghi M et al. · 2021
193
A Randomized Controlled Trial to Determine the Effects of Curcumin and Epigallocatechin-3-Gallate Supplementation on Serum Brain-Derived Neurotrophic Factor and Mood Disturbance in Adults
Cavanah AM, Robinson LA, Aguilar MM, Molaison EF, Greene MW, Roberts MD et al. · 2026
194
Curcumin and/or omega-3 polyunsaturated fatty acids supplementation reduces insulin resistance and blood lipids in individuals with high risk of type 2 diabetes: a randomised controlled trial
Thota RN, Acharya SH, Garg ML · 2019
195
Oral Curcumin (Meriva) Is Effective as an Adjuvant Treatment and Is Able to Reduce IL-22 Serum Levels in Patients with Psoriasis Vulgaris
Antiga E, Bonciolini V, Volpi W, Del Bianco E, Caproni M · 2015
196
Safety and efficacy of a mucoadhesive phytomedication containing curcuminoids and Bidens pilosa L. extract in the prevention and treatment of radiochemotherapy-induced oral mucositis: Triple-blind, randomized, placebo-controlled, clinical trial
Arantes DAC, da Silva ACG, Freitas NMA, Lima EM, de Oliveira AC, Marreto RN et al. · 2021
197
Effects of supplementation with curcuminoids on serum adipokines in critically ill patients: a randomized double-blind placebo-controlled trial
Shadnoush M, Zahedi H, Norouzy A, Sahebkar A, Sadeghi O, Najafi A et al. · 2020
198
[Curcumin in children with autism spectrum disorder: systemic inflammation, sensory regulation, and gut-brain interaction disorders. A randomized, double-blind, placebo-controlled clinical trial (CURATEA)]
Vergara Serpa JJ, Sumalla Cano S · 2026
199
The Effect of Curcumin Plus Piperine on Mental Health Status, Sleep Quality, and Anthropometric Indices in Patients with Non-Proliferative Diabetic Retinopathy: A Randomized Double-Blind Placebo-Controlled Trial
Amini S, Dehghani A, Sahebkar A, Iraj B, Rezaeian-Ramsheh A, Askari G et al. · 2026
200
The effects of Mixodin supplementation on migraine headache characteristics, oxidative stress and inflammatory biomarkers in patients with migraine: a double-blind, placebo-controlled, randomized trial
Askari MA, Golpour-Hamedani S, Khorvash F, Yegdaneh A, Vajdi M · 2026
201
Anti-Inflammatory Properties of Curcumin as Add-On Therapy in Patients with MS-Prospective, Comparative, Randomized, Pilot Study
Kukushkina A, Rogovskii V, Zhilenkova O, Sadekov T, Melnikov M, Boyko A · 2026
202
The effect of a topical curcumin formulation (VAS-101) on knee pain in adults with knee osteoarthritis: a randomised, double-blind, placebo-controlled study
Lopresti AL, Antony B, Smith SJ · 2026
203
Safety assessment and gastrointestinal tolerance of a novel highly bioavailable turmeric extract formulation: A randomised, double-blind, placebo controlled clinical trial
Laval J, Phipps KR, Brinet S, Fournier MC, Douillard B, Pham S et al. · 2026
204
Comparative evaluation of novel nano-herbal and photo-biomodulation therapy for gingivitis in visually impaired children: A randomized controlled study
Shrutha SP, Havale R, Chowdary YV, Balkattu K, Siddanatham VS · 2025
205
The efficacy of curcumin-piperine supplementation in patients with nonproliferative diabetic retinopathy: An optical coherence tomography angiography-based randomized controlled trial
Amini S, Dehghani A, Sahebkar A, Iraj B, Rezaeian-Ramsheh A, Askari G et al. · 2024
206
Clinical Evaluation of Anti-inflammatory and Analgesic Activities of AQUA-TURM (branded extract of Curcuma longa) in Individuals Suffering from Osteoarthritis of Knee(s): A Randomized, Double Blind, Placebo Controlled clinical study
Pande S, Godatwar P, Agiwal S, Khatau K, Tamoli S · 2023
207
Effect of Turmeric-Boswellia-Sesame Formulation in Menstrual Cramp Pain Associated with Primary Dysmenorrhea-A Double-Blind, Randomized, Placebo-Controlled Study
Agarwal D, Chaudhary P · 2023
208
Curcuminoids can prevent post-contrast acute kidney injury in chronic kidney disease patients: A randomized controlled trial
Jaturapisanukul S, Kurathong S, Ngamvichchukorn T, Trakarnvanich T · 2022
209
Oral nano-curcumin formulation efficacy in the management of mild to moderate outpatient COVID-19: A randomized triple-blind placebo-controlled clinical trial
Ahmadi R, Salari S, Sharifi MD, Reihani H, Rostamiani MB, Behmadi M et al. · 2021
210
Chemopreventive Synergism between Green Tea Extract and Curcumin in Patients with Potentially Malignant Oral Disorders: A Double-blind, Randomized Preliminary Study
Neetha MC, Panchaksharappa MG, Pattabhiramasastry S, Shivaprasad NV, Venkatesh UG · 2020
211
Herbal formulation "turmeric extract, black pepper, and ginger" versus Naproxen for chronic knee osteoarthritis: A randomized, double-blind, controlled clinical trial
Heidari-Beni M, Moravejolahkami AR, Gorgian P, Askari G, Tarrahi MJ, Bahreini-Esfahani N · 2020
212
Efficacy of curcuminoids for reducing postoperative pain after laparoscopic gynecologic surgery: A pilot randomized trial
Phoolcharoen N, Oranratanaphan S, Ariyasriwatana C, Worasethsin P · 2019
213
A comparative study to evaluate the efficacy of lycopene and curcumin in oral submucous fibrosis patients: A randomized clinical trial
Saran G, Umapathy D, Misra N, Channaiah SG, Singh P, Srivastava S et al. · 2018
214
Safety, Tolerance, and Enhanced Efficacy of a Bioavailable Formulation of Curcumin With Fenugreek Dietary Fiber on Occupational Stress: A Randomized, Double-Blind, Placebo-Controlled Pilot Study
Pandaran Sudheeran S, Jacob D, Natinga Mulakal J, Gopinathan Nair G, Maliakel A, Maliakel B et al. · 2016
215
Curcumin plus piperine improve body composition in patients with inflammatory bowel disease: a randomized, double-blind, placebo-controlled clinical trial
da Paz Martins AS, de Araújo ORP, da Silva Gomes A, Araujo FLC, Júnior JO, de Vasconcelos JKG et al. · 2025
216
The Combined Effects of an Anti-Inflammatory Diet and Curcumin Supplementation on Thyroid Function and Lipid Profile in Patients With Hashimoto's Thyroiditis: A Double Blind Randomised Clinical Trial
Bourbour F, Mahdavi B, Naghshi N, Yari Z, Hosseini SM, Kalbasi S et al. · 2026
217
The Additive Effects of Curcumin Supplementation in Addition to an Anti-Inflammatory Diet on Inflammatory Indices in Patients With Hashimoto's Thyroiditis (HT): A Double Blind Randomized Controlled Clinical Trial
Bourbour F, Mahdavi B, Naghshi N, Yari Z, Hosseini SM, Kalbasi S et al. · 2026
218
Comparison of oral Nano-Curcumin with oral prednisolone on oral lichen planus: a randomized double-blinded clinical trial
Kia SJ, Basirat M, Mortezaie T, Moosavi MS · 2020
219
The effects of curcumin-piperine supplementation on inflammatory, oxidative stress and metabolic indices in patients with ischemic stroke in the rehabilitation phase: a randomized controlled trial
Boshagh K, Khorvash F, Sahebkar A, Majeed M, Bahreini N, Askari G et al. · 2023
220
Effect of nano-curcumin supplementation on liver fibrosis in patients with NAFLD-associated fibrosis: a double-blind randomized controlled trial
Gerami H, Mozaffari-Khosravi H, Mansour A, Sohrabpour AA, Poustchi H, Hashemi Taheri AP et al. · 2025
221
Effects of curcuminoids on inflammatory status in patients with non-alcoholic fatty liver disease: A randomized controlled trial
Saberi-Karimian M, Keshvari M, Ghayour-Mobarhan M, Salehizadeh L, Rahmani S, Behnam B et al. · 2020
222
The effect of curcumin with piperine supplementation on pro-oxidant and antioxidant balance in patients with non-alcoholic fatty liver disease: a randomized, double-blind, placebo-controlled trial
Mirhafez SR, Farimani AR, Gholami A, Hooshmand E, Tavallaie S, Nobakht M Gh BF · 2019
223
Overall Survival of Glioblastoma Patients Treated With a Combination of 7 Micronutrients: A Nutraceutical Trial
Rooprai HK, Lawrence P, Ashkan K, Beaney R, Pilkington GJ, Gullan RW · 2026
224
Effect of phospholipid curcumin Meriva on liver histology and kidney disease in nonalcoholic steatohepatitis: A randomized, double-blind, placebo-controlled trial
Musso G, Pinach S, Mariano F, Saba F, De Michieli F, Framarin L et al. · 2025
225
The effect of turmeric-Boswellia formulation (Rhuleave-K) in posture-related low back soreness and discomfort: A randomized double blinded placebo controlled trial
Gupta A, Agarwal A · 2025
226
Impaired postprandial GLP-2 response enhances endotoxemia, systemic inflammation, and kidney injury in metabolic dysfunction-associated steatohepatitis (MASH): effect of phospholipid curcumin meriva
Musso G, Alberto M, Mariano F, Cassader M, De Michieli F, Riva A et al. · 2024
227
The Use of Herbal Medicine in Sudden Sensorineural Hearing Loss in Diabetic Patients
Tajdini A, Karimi Yazdi A, Ravand H, Sahebi L · 2023
228
Randomized, Double-Blind, Placebo-Controlled Trial of Meriva (Curcuminoids) as a Candidate Chemoprevention Agent for Gastric Carcinogenesis
Gonzalez-Pons M, Dominguez RL, Montalvan-Sanchez EE, Foster NR, Strand CA, Hernandez-Marrero J et al. · 2026
229
Bioavailability-Enhanced Curcumin (CurcuBoost®) as Adjunct Therapy Improves Symptoms in Knee Osteoarthritis: A Randomized Clinical Trial
Bansal L, Kumar D · 2026
230
Effect of ArtemiC in patients with COVID-19: A Phase II prospective study
Hellou E, Mohsin J, Elemy A, Hakim F, Mustafa-Hellou M, Hamoud S · 2022
231
Effects of nanomicelle curcumin capsules on prevention and treatment of oral mucosits in patients under chemotherapy with or without head and neck radiotherapy: a randomized clinical trial
Kia SJ, Basirat M, Saedi HS, Arab SA · 2021
232
A Randomized, Double Blind, Placebo Controlled, Parallel-Group Study to Evaluate the Safety and Efficacy of Curene® versus Placebo in Reducing Symptoms of Knee OA
Panda SK, Nirvanashetty S, Parachur VA, Mohanty N, Swain T · 2018
233
Safety, tolerability and pharmacokinetics of liposomal curcumin in healthy humans
Storka A, Vcelar B, Klickovic U, Gouya G, Weisshaar S, Aschauer S et al. · 2015
234
Short-term effects of highly-bioavailable curcumin for treating knee osteoarthritis: a randomized, double-blind, placebo-controlled prospective study
Nakagawa Y, Mukai S, Yamada S, Matsuoka M, Tarumi E, Hashimoto T et al. · 2014
235
Can curcumin supplementation break the vicious cycle of inflammation, oxidative stress, and uremia in patients undergoing peritoneal dialysis?
Reis DCMV, Alvarenga L, Cardozo LFMF, Baptista BG, Fanton S, Paiva BR et al. · 2024
236
Safety of NR-INF-02, an Extract of Curcuma Longa Containing Turmerosaccharides, in Healthy Volunteers: A Randomized, Open-label Clinical Trial
Selvi M, Mohan Mv R, Bethapudi B, Mundkinajeddu D, Kumari S · 2022
237
Supportive treatment of vascular dysfunction in pediatric subjects with obesity: the OBELIX study
Pecoraro L, Zoller T, Atkinson RL, Nisi F, Antoniazzi F, Cavarzere P et al. · 2022
238
Effects of Curcumin and Fenugreek Soluble Fiber on the Physical Working Capacity at the Fatigue Threshold, Peak Oxygen Consumption, and Time to Exhaustion
Herrick LP, Goh J, Menke W, Campbell MS, Fleenor BS, Abel MG et al. · 2020
239
Effect of Turmeric Supplementation on Blood Pressure and Serum Levels of Sirtuin 1 and Adiponectin in Patients with Nonalcoholic Fatty Liver Disease: A Double-Blind, Randomized, Placebo-Controlled Trial
Kalhori A, Rafraf M, Navekar R, Ghaffari A, Jafarabadi MA · 2022
240
The efficacy of curcumin-piperine co-supplementation on clinical symptoms, duration, severity, and inflammatory factors in COVID-19 outpatients: a randomized double-blind, placebo-controlled trial
Askari G, Sahebkar A, Soleimani D, Mahdavi A, Rafiee S, Majeed M et al. · 2022
241
Randomised Clinical Trial Study: The Combination of Vitamin D and Curcumin Piperine Attenuates Disease Activity and Pro-inflammatory Cytokines Levels Insystemic Lupus Erythematosus Patients
Wahono CS, Susianti H, Hakim AL, Rosita F, Pratama MZ, Rahman PA et al. · 2024
242
A randomized, placebo-controlled, crossover clinical trial to evaluate the effect of a turmeric formulation on muscle soreness and function recovery in moderately active adults
Schönenberger KA, Laval J, Woods T, Truillet R, Naranjo-Modad S, Mettler S et al. · 2025
243
Effects of a Low-Dose Spirulina/Turmeric Supplement on Cardiometabolic and Antioxidant Serum Markers of Patients With Abdominal Obesity
Gómez-Téllez A, Sierra-Puente D, Muñoz-Gómez R, Ibarra-Pitts A, Guevara-Cruz M, Hernández-Ortega M et al. · 2020
244
Effect of nano-curcumin supplementation on cardiometabolic risk factors, physical and psychological quality of life, and depression in patients with coronary slow flow phenomenon: a randomized double-blind clinical trial
Soltani M, Hosseinzadeh-Attar MJ, Rezaei M, Alipoor E, Vasheghani-Farahani A, Yaseri M et al. · 2024
245
Randomized placebo-controlled, double-blind clinical trial of nanoemulsion curcumin in women with aromatase inhibitor-induced arthropathy: an Alliance/NCORP pilot trial
Lustberg M, Fan-Havard P, Wong FL, Hill K, Phelps MA, Herrera KW et al. · 2024
246
Effect of nano-curcumin supplementation on angina status, and traditional and novel cardiovascular risk factors in overweight or obese patients with coronary slow flow phenomenon: a randomized double-blind placebo-controlled clinical trial
Rezaei M, Soltani M, Alipoor E, Rezayat SM, Vasheghani-Farahani A, Yaseri M et al. · 2024
247
Highly bioavailable micellar curcuminoids accumulate in blood, are safe and do not reduce blood lipids and inflammation markers in moderately hyperlipidemic individuals
Kocher A, Bohnert L, Schiborr C, Frank J · 2016
248
Curcuminoid supplementation for vasomotor symptoms in postmenopausal women: a pilot, randomized, double-blind, placebo-controlled proof-of-concept trial
Buntoonprayuk J, Chattrakulchai K, Vallibhakara O, Prasanchit P, Vallibhakara SA · 2026
249
Antimicrobial efficacy of disinfecting solutions against S. mutans on toothbrushes for school children in Uttar Pradesh, India
Singh S, Alok A, Shahnawaz K, Kumar S, Ramdas Naik S, Piyush K · 2026
250
Comparative Assessment of Subgingivally Delivered 2% Curcumin Gel as an Adjunct to Scaling and Root Planing in Smokers with Chronic Periodontitis: A Clinical Study
Gupta S, Jyothi SG, Siddiqui A, Dhanai A, Yadav H, Singh U · 2025
251
Role of oral bio-enhanced curcumin in dry eye disease
Kapil D, Bari A, Sharma N, Velpandian T, Sinha R, Maharana P et al. · 2025
252
Curcumin supplementation combined with high intensity interval training modulates serum irisin and lipid profile in obese women: "A randomized double-blind clinical trial"
Gharakhanlou BJ, Bonab SB, Amaghani A, Shiri-Shahsavar MR · 2025
253
The effectiveness of curcumin as a safe agent on hearing threshold improvement in patients with chronic kidney disease: a double-blind, placebo-controlled trial
Doostkam A, Iravani K, Malekmakan L, Gholamabbas G, Roozbeh J, Soltaniesmaeili A · 2024
254
Evaluation of Curcumin-Piperine Supplementation in COVID-19 Patients Admitted to the Intensive Care: A Double-Blind, Randomized Controlled Trial
Askari G, Bagherniya M, Kiani Z, Alikiaii B, Mirjalili M, Shojaei M et al. · 2023
255
Analysis of Curcumin as a Radiosensitizer in Cancer Therapy with Serum Survivin Examination: Randomised Control Trial
Hidayat YM, Wagey F, Suardi D, Susanto H, Laihad BJ, Tobing MDL · 2021
256
Recovery Of Bone And Muscle Mass In Patients With Chronic Kidney Disease And Iron Overload On Hemodialysis And Taking Combined Supplementation With Curcumin And Resveratrol
Murillo Ortiz BO, Fuentes Preciado AR, Ramírez Emiliano J, Martínez Garza S, Ramos Rodríguez E, de Alba Macías LA · 2019
257
The effects of curcumin on the prevention of atrial and ventricular arrhythmias and heart failure in patients with unstable angina: A randomized clinical trial
Dastani M, Bigdelu L, Hoseinzadeh M, Rahimi HR, Karimani A, Hooshang Mohammadpour A et al. · 2019
258
Nutraceutical Effects on Glucose and Lipid Metabolism in Patients with Impaired Fasting Glucose: A Pilot, Double-Blind, Placebo-Controlled, Randomized Clinical Trial on a Combined Product
Cicero AFG, Fogacci F, Morbini M, Colletti A, Bove M, Veronesi M et al. · 2017
259
Mitigation of Systemic Oxidative Stress by Curcuminoids in Osteoarthritis: Results of a Randomized Controlled Trial
Panahi Y, Alishiri GH, Parvin S, Sahebkar A · 2016
260
Impact of Supplementation with Curcuminoids on Systemic Inflammation in Patients with Knee Osteoarthritis: Findings from a Randomized Double-Blind Placebo-Controlled Trial
Rahimnia AR, Panahi Y, Alishiri G, Sharafi M, Sahebkar A · 2015
261
Curcumin supplementation improves vascular endothelial function in healthy middle-aged and older adults by increasing nitric oxide bioavailability and reducing oxidative stress
Santos-Parker JR, Strahler TR, Bassett CJ, Bispham NZ, Chonchol MB, Seals DR · 2017
262
Effects of Curcuma longa L. and Green Propolis Extract-Loaded Microcapsules Supplementation on Inflammation in Hemodialysis Patients: Preliminary Results of a Randomized Clinical Trial
Britto I, Couto H, de Paiva BR, de Brito JS, Alvarenga L, Cardozo LFMF et al. · 2025
263
Oral curcumin for Alzheimer's disease: tolerability and efficacy in a 24-week randomized, double blind, placebo-controlled study
Ringman JM, Frautschy SA, Teng E, Begum AN, Bardens J, Beigi M et al. · 2012
264
Inflammatory and Metabolic Biomarker Assessment in a Randomized Presurgical Trial of Curcumin and Anthocyanin Supplements in Patients with Colorectal Adenomas
Macis D, Briata IM, D'Ecclesiis O, Johansson H, Aristarco V, Buttiron Webber T et al. · 2023
265
Curcumin Supplementation Improves Gastrointestinal Symptoms in Women with Severe Obesity: A Double-Blind, Randomized, Placebo-Controlled Trial-A Pilot Study
Kattah FM, Figueiredo N, Bezerra KK, Oliveira ES, Melo CC, Lima GB et al. · 2025
266
Impact of curcumin supplementation on expression of inflammatory transcription factors in hemodialysis patients: A pilot randomized, double-blind, controlled study
Alvarenga L, Salarolli R, Cardozo LFMF, Santos RS, de Brito JS, Kemp JA et al. · 2020
267
Bioenhancer Assessment of Black Pepper with Turmeric on Self-Reported Pain Ratings in Adults: A Randomized, Cross-Over, Clinical Trial
Durham L, Oster RA, Ithurburn M, Reynolds C, Hill JO, Smith DL · 2026
268
Comparison of the efficacy of placental extract gel vs. curcumin gel in the treatment of oral aphthous ulcer: a randomized clinical trial
Thangeswaran S, S N, Maniangat Luke A, Ingafou MSH · 2026
269
Evaluation of the efficacy of curcuminoids gel as an adjunct to scaling and root planing in the treatment of chronic periodontitis: A clinicobiochemical study
Ramalingam K, Dorairaj J, Saminathan S, Ravi S, Ravindran S, Desingu V · 2025
270
Curcumin's effect on serum zinc, copper and magnesium levels in obese individuals
Saberi-Karimian M, Orooji A, Taghizadeh N, Ekhteraee Toosi MS, Ferns GA, Aghasizadeh M et al. · 2023
271
Pharmacokinetics of a Single Dose of Turmeric Curcuminoids Depends on Formulation: Results of a Human Crossover Study
Fança-Berthon P, Tenon M, Bouter-Banon SL, Manfré A, Maudet C, Dion A et al. · 2021
272
Comparative evaluation of a modified endodontic approach using Curcuma longa L. and conventional pulpectomy in primary molars: A randomized clinical trial
Sahiti PS, Kamatham R · 2021
273
Effects of a Cinnamon, Curcumin/Turmeric Dietary Supplement on Glucose, Lipid, and Cognitive Measures
Young H, Clayton D, Masis N, Gaylor C, Benton D · 2020
274
Curcumin Combined with FOLFOX Chemotherapy Is Safe and Tolerable in Patients with Metastatic Colorectal Cancer in a Randomized Phase IIa Trial
Howells LM, Iwuji COO, Irving GRB, Barber S, Walter H, Walter H et al. · 2019
275
Efficacy and safety of curcumin in patients with hand osteoarthritis: a pilot double-blinded randomised controlled trial
Tuntiyatorn P, Lerspongpaibool C, Kanchanathepsak T, Watcharananan I, Tawonsawatruk T · 2025
276
Adiponectin levels in myeloma patients after curcumin supplementation: A randomized clinical pilot study
Santosa D, Rizqi DM, Pangarsa EA, Setiawan B, Suyono S, Tobing ML et al. · 2025
277
No effect of the turmeric root phenol curcumin on prednisolone-induced glucometabolic perturbations in men with overweight or obesity
Hellmann PH, Bagger JI, Carlander KR, Hansen KB, Forman JL, Størling J et al. · 2023
278
Superior Bioavailability of a Novel Curcumin Formulation in Healthy Humans Under Fasting Conditions
Kothaplly S, Alukapally S, Nagula N, Maddela R · 2022
279
A novel bioavailable hydrogenated curcuminoids formulation (CuroWhite™) improves symptoms and diagnostic indicators in rheumatoid arthritis patients - A randomized, double blind and placebo controlled study
Jacob J, Amalraj A, Raj KKJ, Divya C, Kunnumakkara AB, Gopi S · 2019
280
Ubiquitin Proteasome System Activity is Suppressed by Curcumin following Exercise-Induced Muscle Damage in Human Skeletal Muscle
Cardaci TD, Machek SB, Wilburn DT, Hwang PS, Willoughby DS · 2021
281
Influence of enhanced bioavailable curcumin on obesity-associated cardiovascular disease risk factors and arterial function: A double-blinded, randomized, controlled trial
Campbell MS, Ouyang A, I M K, Charnigo RJ, Westgate PM, Fleenor BS · 2019
282
A Placebo-Controlled Double-Blinded Randomized Pilot Study of Combination Phytotherapy in Biochemically Recurrent Prostate Cancer
van Die MD, Williams SG, Emery J, Bone KM, Taylor JM, Lusk E et al. · 2017
283
Efficacy of topical curcuma longa in the healing of extraction sockets: A split-mouth clinical trial
Pandya K, Abbinayah D, Selvakumar D, Jayakumar N · 2023
284
The effect of turmeric and black pepper powder incorporated in breakfast on postprandial glycemia, appetite, palatability, and gastrointestinal well-being in normal-weight adults
Khan S, Arif M, Laraib H, Naqvi SN, Shah OA, Farooq U et al. · 2024
285
Efficacy of Curcumin on Treating Cancer Anorexia-Cachexia Syndrome in Locally or Advanced Head and Neck Cancer: A Double-Blind, Placebo-Controlled Randomised Phase IIa Trial (CurChexia)
Thambamroong T, Seetalarom K, Saichaemchan S, Pumsutas Y, Prasongsook N · 2022
286
A Placebo-Controlled, Pseudo-Randomized, Crossover Trial of Botanical Agents for Gulf War Illness: Curcumin (Curcuma longa), Boswellia (Boswellia serrata), and French Maritime Pine Bark (Pinus pinaster)
Donovan EK, Kekes-Szabo S, Lin JC, Massey RL, Cobb JD, Hodgin KS et al. · 2021
287
Reduction of delayed onset muscle soreness by a novel curcumin delivery system (Meriva®): a randomised, placebo-controlled trial
Drobnic F, Riera J, Appendino G, Togni S, Franceschi F, Valle X et al. · 2014
288
Multidimensional LDCT Imaging Endpoints for a Randomized Pilot Phase II Trial of Curcumin and Omega-3 Fatty Acids for Lung Cancer Chemoprevention: Results of a Randomized Pilot Trial
Kumar NB, Schabath M, Alexandrow M, Gray J, Tanventyanon T, Khalil F et al. · 2026
289
Multidimensional LDCT Imaging Endpoints for an Early-Phase Trial of Curcumin and Omega-3 Fatty Acids for Lung Cancer Chemoprevention: Results of a Randomized Pilot Trial
Kumar NB, Schabath M, Alexandrow M, Gray J, Tanventyanon T, Khalil F et al. · 2026
290
Enhanced bioavailability of a novel double-layered nano-liposomal curcumin (BNT-C060): a randomized, double-blind, clinical trial
Kim DS, Kim HK, Ha KC, Jang GH, Park SH, Kim DH et al. · 2026
291
Impact of 3-day turmeric supplementation on fasting and postprandial LPS and chylomicron-related markers in patients with IBS: A randomized crossover trial
van den Belt M, JanssenDuijghuijsen L, Tomassen M, de Roos N, Witteman B, Fança-Berthon P et al. · 2026
292
Comparative Pharmacokinetics of Curcuminoids from Water-Dispersible Turmeric Extract Against a Curcuminoids-Piperine Combination: An Open-Label, Randomized, Balanced, 2-Treatment, 2-Sequence, 2-Period Crossover Study
Thanawala S, Shah R, Doyle L, Upadhyay V · 2024
293
The Curcumin Supplementation with Piperine Can Influence the Acute Elevation of Exercise-Induced Cytokines: Double-Blind Crossover Study
Miranda-Castro S, Aidar FJ, de Moura SS, Marcucci-Barbosa L, Lobo LF, de Assis Dias Martins-Júnior F et al. · 2022
294
Micellar Curcumin: Pharmacokinetics and Effects on Inflammation Markers and PCSK-9 Concentrations in Healthy Subjects in a Double-Blind, Randomized, Active-Controlled, Crossover Trial
Grafeneder J, Derhaschnig U, Eskandary F, Buchtele N, Sus N, Frank J et al. · 2022
295
Determination of efficacy of curcumin and Tulsi extracts as local drugs in periodontal pocket reduction: A clinical and microbiological study
Rahalkar A, Kumathalli K, Kumar R · 2021
296
An Open Label, Randomized, Comparative Bioavailability Study of BioTurm™ Extract Versus Curcuma longa Extract With Piperine in Healthy Adult Volunteers
Malhotra VK, Deshpande AC, Tamoli S, Soman GS, Sabnis Shinde R, Soman AD · 2025
297
Comparative bioavailability of curcuminoids from a water-dispersible high curcuminoid turmeric extract against a generic turmeric extract: a randomized, cross-over, comparative, pharmacokinetic study
Thanawala S, Shah R, Alluri KV, Somepalli V, Vaze S, Upadhyay V · 2021
298
Dietary Polyphenol and Methylsulfonylmethane Supplementation Improves Immune, DAMP Signaling, and Inflammatory Responses During Recovery From All-Out Running Efforts
McFarlin BK, Hill DW, Vingren JL, Curtis JH, Tanner EA · 2021
299
Pharmacokinetic Analysis of the Bioavailability of AQUATURM®, a Water-Soluble Curcumin Formulation, in Comparison to a Conventional Curcumin Tablet, in Human Subjects
Jabur L, Pandey R, Mikhael M, Niedermayer G, Gyengesi E, Mahns D et al. · 2025
300
Pharmacokinetic Analysis of the Bioavailability of AQUATURM®, a Water-Soluble Curcumin Formulation in Comparison to a Conventional Curcumin Tablet, in Human Subjects
Muench G · 2024
301
Oil-Based Curcuminoid Phospholipid Formulation Mimicking Natural Digestion Enhances Oral Bioavailability of Curcuminoids in Healthy Subjects
Wagner T, Wacker R, Klein T, Kompek A, Schön C · 2024
302
Impact of Curcuma longa L. extract supplementation on the gut microbiota of hemodialysis patients
Alvarenga L, Cardozo L, Schultz J, Modolon F, Rosado A, Mafra D · 2026
303
Tetrahydrocurcuminoid cream plus targeted narrowband UVB phototherapy for vitiligo: a preliminary randomized controlled study
Asawanonda P, Klahan SO · 2010
304
Comparative Evaluation of Curcumin Gel With Diode Laser (970 nm) Versus Diode Laser Alone For Pocket Depth Reduction in Chronic Localised Periodontitis - A Split-Mouth Randomized Clinical Trial
Sharath S, Kamath DG, Shenoy N · 2025
305
Evaluation of the Impact of Different Doses of Curcuma longa L. on Antioxidant Capacity: A Randomized, Double-Blind, Crossover Pilot Trial
Gomes TLN, Zenha RSS, Antunes AH, Faria FR, Rezende KR, de Souza EL et al. · 2021
306
Effectiveness and safety of an ayurvedic nutraceutical for improving clinical parameters of liver function in participants with metabolic dysfunction-associated steatotic liver disease: a randomized, placebo-controlled, preliminary phase 2 exploratory clinical trial
Messier H, Patel J, Bhomia V, Kataria D, Patel G · 2026
307
The effect of curcumin and piperine co-supplementation on glycemic indices in prediabetes: A triple-blind randomized controlled trial
Ghazaee H, Sahebkar A, Mazloum Khorasani Z, Emadzadeh M · 2026
308
Dietary intake and blood biomarker changes with a one-week pesco-vegetarian diet intervention supplemented with varying dose of ginger and curcumin: A single-blinded randomized clinical trial
Mossburg K, Matheny JB, Masuda H · 2026
309
Efficacy of GV22202 in subjects with mild knee osteoarthritis: A randomized, triple arm trial assessing pain reduction and functional outcomes
Srivastava A, Vinay V, Singh MK · 2026
310
The effect of curcumin capsule on the severity and duration of primary dysmenorrhea among students: A triple-blind randomized controlled trial in the West of Iran
Abdoli S, Khazaei S, Mehrpooya M, Kazemi F, Jenabi E, Yazdaniroshan R · 2025
311
The influence of food matrices on the bioavailability of curcuminoids from a dried colloidal turmeric suspension: a randomized, crossover, clinical trial
Schönenberger KA, Ranzini C, Laval J, Bellenger P, Tenon M, Fança-Berthon P · 2025
312
Phytotherapy Might Have a Role in Reducing Unnecessary Prostate Biopsies: Results from an Exploratory, Randomized Controlled Trial of Two Different Phytotherapeutic Agents
Cai T, Tamanini I, Puglisi M, Bizzotto L, Rizzo M, Liguori G et al. · 2024
313
Oral mucositis management with photobiomodulation, Bidens pilosa L. (Asteraceae) and Curcuma longa L. (Zingiberaceae), the FITOPROT herbal medicine, and its influence on inflammatory cytokine levels: a randomized clinical trial
Pereira CH, Martins AFL, Morais MO, de Sousa-Neto SS, da Silva ACG, Arantes DAC et al. · 2024
314
Effects of Mediterranean Diet, Curcumin, and Resveratrol on Mild-to-Moderate Active Ulcerative Colitis: A Multicenter Randomized Clinical Trial
Erol Doğan Ö, Karaca Çelik KE, Baş M, Alan EH, Çağın YF · 2024
315
Effect of Curcumin Plus Piperine on Redox Imbalance, Fecal Calprotectin and Cytokine Levels in Inflammatory Bowel Disease Patients: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
Martins ASDP, Araújo ORP, Gomes ADS, Araujo FLC, Oliveira Junior J, Vasconcelos JKG et al. · 2024
316
Curcuma longa extract reduces serum inflammatory markers and postprandial hyperglycemia in healthy but borderline participants with overweight and glycemia in the normal/prediabetes range: a randomized, double-blind, and placebo-controlled trial
Uchio R, Okuda-Hanafusa C, Sakaguchi H, Saji R, Muroyama K, Murosaki S et al. · 2024
317
Oral preparation of hyaluronic acid, chondroitin sulfate, N-acetylglucosamine, and vitamin C improves sexual and urinary symptoms in participants with recurrent urinary tract infections: a randomized crossover trial
Boeri L, De Lorenzis E, Lucignani G, Turetti M, Silvani C, Zanetti SP et al. · 2024
318
Acute supplementation with a curcuminoid-based formulation fails to enhance resting or exercise-induced NRF2 activity in males and females
Thorley J, Alhebshi A, Rodriguez-Mateos A, Zhang Z, Bailey SJ, Martin NRW et al. · 2024
319
Effect of Curcuma longa (Turmeric), as an intra-canal medicament, on inter-appointment endodontic pain in patients with symptomatic irreversible pulpitis: A randomized controlled clinical trial
Singla R, Gupta C, Gill GS, Jain N, Arora S, Algarni YA et al. · 2024
320
Effect of Curcumin plus Piperine on Redox Imbalance and Inflammation in Inflammatory Bowel Disease Patients: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
Martins ASdP, Araújo ORPd, Gomes AdS, Araujo FLC, Oliveira Junior J, Vasconcelos JKGd et al. · 2024
321
Establishment of a Mesoamerican-Caribbean South-South Research Platform: Challenges in the Meriva (Curcuminoids) Gastric Cancer Chemoprevention Trial
Montalvan-Sanchez EE, Hernandez-Marrero J, Norwood DA, González-Pons M, Dominguez RL, Rodriguez LM et al. · 2024
322
Effect of Curcumin Intake on Skeletal Muscle Oxygen Saturation Parameters in Older Participants
Ramos-Junior OJF, Pinheiro VDS, Souza TGDS, Alvares TS · 2024
323
Effect of Curcuma longa extract on serum inflammatory markers and MRI-based synovitis in knee osteoarthritis: secondary analyses from the CurKOA randomised trial
Wang Z, Winzenberg T, Singh A, Aitken D, Blizzard L, Boesen M et al. · 2023
324
Efficacy of curcumin plus piperine co-supplementation in moderate-to-high hepatic steatosis: A double-blind, randomized, placebo-controlled clinical trial
Sharifi S, Bagherniya M, Khoram Z, Ebrahimi Varzaneh A, Atkin SL, Jamialahmadi T et al. · 2023
325
Effects of a mucoadhesive phytomedicine (Curcuma longa L. and Bidens pilosa L.) on radiotherapy-induced oral mucositis and quality of life of patients undergoing head and neck cancer treatment: randomized clinical trial
Martins AFL, Pereira CH, Morais MO, de Sousa-Neto SS, Valadares MC, Freitas NMA et al. · 2023
326
Effects of turmeric extract supplementation on the lipid and lipoprotein subfraction profile in hemodialysis patients: A randomised, double-blind, crossover and controlled trial
Alvarenga L, Cardozo LFMF, Ribeiro-Alves M, Damasceno NRT, Berretta AA, Lima JA et al. · 2023
327
The effect of curcumin on anthropometric indices, blood pressure, lipid profiles, fasting blood glucose, liver enzymes, fibrosis, and steatosis in non-alcoholic fatty livers
Safari Z, Bagherniya M, Khoram Z, Ebrahimi Varzaneh A, Heidari Z, Sahebkar A et al. · 2023
328
Clinical usefulness of nutraceutics with acetyl-L-carnitine, α-lipoic acid, phosphatidylserine, curcumin, C, E and B-group vitamins in patients awaiting for carpal tunnel release during COVID-19 pandemic: a randomized controlled open label prospective study
D'Orio M, De Vitis R, Taccardo G, Rocchi L, Ferrari F, Perna A et al. · 2023
329
Antibacterial efficacy of manuka honey, ocimum sanctum, curcuma longa and 0.2% chlorhexidine mouthwash on the level of streptococcus mutans and lactobacillus acidophilus - A randomized controlled trial
Jain A, Singh V, Lukram A, Chatterjee S, Khan AM, Dawar G · 2022
330
Turmeric supplementation with piperine is more effective than turmeric alone in attenuating oxidative stress and inflammation in hemodialysis patients: A randomized, double-blind clinical trial
Freitas E Silva-Santana NC, Rodrigues HCN, Pereira Martins TF, Braga CC, Silva MAC, Carlos da Cunha L et al. · 2022
331
Bioactive Yoghurt Containing Curcumin and Chlorogenic Acid Reduces Inflammation in Postmenopausal Women
Ahmed Nasef N, Thota RN, Mutukumira AN, Rutherfurd-Markwick K, Dickens M, Gopal P et al. · 2022
332
Comparative Pharmacokinetic of Curcuminoids Formulations with an Omega-3 Fatty Acids Monoglyceride Carrier: A Randomized Cross-Over Triple-Blind Study
Aguilera EC, Vachon A, Plourde M · 2022
333
A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial Assessing Efficacy and Safety of a Novel Low-Dose Turmeric Extract Formulation in Healthy Adults with Chronic Knee Pain
Thanawala S, Shah R, Somepalli V, Alluri KV, Desomayanandam P, Bhuvanendran A · 2021
334
Effects of curcumin on menstrual pattern, premenstrual syndrome, and dysmenorrhea: A triple-blind, placebo-controlled clinical trial
Bahrami A, Zarban A, Rezapour H, Agha Amini Fashami A, Ferns GA · 2021
335
Oral Curcumin With Piperine as Adjuvant Therapy for the Treatment of COVID-19: A Randomized Clinical Trial
Pawar KS, Mastud RN, Pawar SK, Pawar SS, Bhoite RR, Bhoite RR et al. · 2021
336
Bioavailable turmeric extract for knee osteoarthritis: a randomized, non-inferiority trial versus paracetamol
Singhal S, Hasan N, Nirmal K, Chawla R, Chawla S, Kalra BS et al. · 2021
337
Efficacy and safety of a supplement combination on hand pain among people with symptomatic hand osteoarthritis an internet-based, randomised clinical trial the RADIANT study
Liu X, Robbins S, Eyles J, Fedorova T, Virk S, Deveza LA et al. · 2021
338
Dietary Supplementation with Curcumin Reduce Circulating Levels of Glycogen Synthase Kinase-3β and Islet Amyloid Polypeptide in Adults with High Risk of Type 2 Diabetes and Alzheimer's Disease
Thota RN, Rosato JI, Dias CB, Burrows TL, Martins RN, Garg ML · 2020
339
Curcuma longa L. ameliorates asthma control in children and adolescents: A randomized, double-blind, controlled trial
Manarin G, Anderson D, Silva JME, Coppede JDS, Roxo-Junior P, Pereira AMS et al. · 2019
340
Curcumin's Effect on COX-2 and IL-10 Serum in Preeclampsia's Patient Undergo Sectio Caesarea with Spinal Anesthesia
Fadinie W, Lelo A, Wijaya DW, Lumbanraja SN · 2019
341
Effects of Turmeric and Curcumin Dietary Supplementation on Human Gut Microbiota: A Double-Blind, Randomized, Placebo-Controlled Pilot Study
Peterson CT, Vaughn AR, Sharma V, Chopra D, Mills PJ, Peterson SN et al. · 2018
342
Randomized Pharmacokinetic Crossover Study Comparing 2 Curcumin Preparations in Plasma and Rectal Tissue of Healthy Human Volunteers
Asher GN, Xie Y, Moaddel R, Sanghvi M, Dossou KS, Kashuba AD et al. · 2017
343
Co-analgesic therapy for arthroscopic supraspinatus tendon repair pain using a dietary supplement containing Boswellia serrata and Curcuma longa: a prospective randomized placebo-controlled study
Merolla G, Dellabiancia F, Ingardia A, Paladini P, Porcellini G · 2015
344
Treatment for benign thyroid nodules with a combination of natural extracts
Stancioiu F, Mihai D, Papadakis GZ, Tsatsakis A, Spandidos DA, Badiu C · 2019
345
Curcumin Enhances Fed-State Muscle Microvascular Perfusion but Not Leg Glucose Uptake in Older Adults
Deane CS, Din USU, Sian TS, Smith K, Gates A, Lund JN et al. · 2022
346
Colloidal submicron-particle curcumin exhibits high absorption efficiency-a double-blind, 3-way crossover study
Sunagawa Y, Hirano S, Katanasaka Y, Miyazaki Y, Funamoto M, Okamura N et al. · 2015
347
A new curcuma extract (flexofytol®) in osteoarthritis: results from a belgian real-life experience
Appelboom T, Maes N, Albert A · 2014
348
Curcuminoids and Boswellia serrata extracts combination decreases tendinopathy symptoms: findings from an open-label post-observational study
Henrotin Y, Dierckxsens Y, Delisse G, Seidel L, Albert A · 2021
349
New Approach for Enhancing Survival in Glioblastoma Patients: A Longitudinal Pilot Study on Integrative Oncology
Bonucci M, Fuggetta MP, Anelli L, Giannarelli D, Fiorentini C, Ravagnan G · 2025
350
Phytosome complex of curcumin as complementary therapy of advanced pancreatic cancer improves safety and efficacy of gemcitabine: Results of a prospective phase II trial
Pastorelli D, Fabricio ASC, Giovanis P, D'Ippolito S, Fiduccia P, Soldà C et al. · 2018
351
A phase I evaluation of the effect of curcumin on dose-limiting toxicity and pharmacokinetics of irinotecan in participants with solid tumors
Gbolahan OB, O'Neil BH, McRee AJ, Sanoff HK, Fallon JK, Smith PC et al. · 2022
352
Safety evaluation of an effervescent curcuminoids-ascorbic acid-polysaccharide-β-cyclodextrin (CUR-A-Poly-β-CD) inclusion complex powder in healthy volunteers: A non-placebo-controlled pilot study
Pramvichai C, Mongkolwat W, Aluksanasuwan S, Jaidee W, Charoensup R, Pimtong S et al. · 2026
353
Potential Adjunctive Effects of Quercetin-Curcumin Co-Supplementation in Adults with Mild-to-Moderate Long COVID: Results from a Pragmatic Exploratory Real-World Clinical Study
Khan A, Rabbani F, Mumtaz SU, Javed R, Ujjan I, Kanwal A et al. · 2026
354
A Phase 2 Study to Assess the Immunomodulatory Capacity of a Lecithin-based Delivery System of Curcumin in Endometrial Cancer
Tuyaerts S, Rombauts K, Everaert T, Van Nuffel AMT, Amant F · 2018
355
Pilot Trial of Adjunctive Curcumin for Treatment-Resistant Bipolar Depression in Youth: Focus on Inflammation and Oxidative Stress
Osei-Bonsu GA, Dimick MK, Kennedy KG, Barton JS, Sultan AA, Young LT et al. · 2026
356
Nanocurcumin in Oral Disease Therapy: A Review of Innovations and Future Prospects
Wang Q, Jiang K, Lan X, Zhang L, Duan Y, Gao J et al. · 2026
357
From bench to bedside: unlocking the anti-inflammatory, antioxidant, and anticancer promise of curcumin in gynecology
Sanlier NT, Sacinti KG, Turkoglu İ, Sanlier N · 2026
358
Dietary Bioactives in Alzheimer's Disease: A Critical Appraisal of Clinical Trials and Future Nutritional Strategies
Kumari A, Zeng XA · 2026
359
Adjunctive nutraceutical strategies in ulcerative colitis: From molecular pathways to clinical outcomes
Caputo C, De Maio AC, Lombardi A, Sperlongano R, Caraglia M, Cautela D · 2026
360
Dietary polyphenols in colorectal cancer - Mechanisms, clinical evidence, and bioavailability of curcumin, resveratrol, and epigallocatechin-3-gallate: A review
Alqahtani HA · 2026
361
Curcumin for The Management of Skin Diseases: A Review of the Results of Preclinical and Clinical Trials and Nanoformulations
Sivamaruthi BS, Suganthy N, Chaiyasut C, Khongtan S, Fukngoen P, Kesika P · 2026
362
Curcumin in Acne Management: A Narrative Review of Mechanisms and Efficacy
Chen Y, Zhang X, Zeng R · 2026
363
Plant-Derived Polyphenols in the Fight against Colorectal Cancer
Arjona-Ruiz C, Valdez-Morales EE, Guerrero-Alba R · 2026
364
Standardized curcumin formulations in type 2 diabetes mellitus: a precision adjunct strategy targeting bioavailability, glycemic control, and immunometabolic inflammation
Okonta EO, Nnadi CO, Paul-Chima UO · 2026
365
Natural supplements in breast cancer therapy: translational evidence, clinical safety, and emerging challenges
Talath S, El-Tanani M, Wali AF, Rabbani SA, Bhongande B, Ibraheem W et al. · 2026
366
Beyond Conventional Therapy: A Comprehensive Review of Herbal, Traditional, and Emerging Interventions for Polycystic Ovary Syndrome
Bashir S, Shah IM, Javeed S, Rafiquee A, Mir B, Hassan Mir R et al. · 2026
367
From Macronutrients to Functional Foods: Nutritional Strategies for Recovery Following High-Intensity Exercise
Farzana HR, Vigriawan GE, Santini A, Nurkolis F · 2026
368
Phytochemicals from medicinal plants as alternative therapeutics for metabolic syndrome: A review of randomized controlled trials
Rad MS, Jamialahmadi T, Kesharwani P, Sahebkar A · 2025
369
Curcumin and Tetrahydrocurcumin as Multi-Organ Modulators of the Adipose Tissue-Gut-Liver Axis: Mechanistic Insights, Therapeutic Potential, and Translational Challenges
Konaktchieva M, Stojchevski R, Hadzi-Petrushev N, Gagov H, Konakchieva R, Mitrokhin V et al. · 2025
370
Dietary Phytonutrients in Fibromyalgia: Integrating Mechanisms, Biomarkers, and Clinical Evidence-A Narrative Review
Kahraman T, Ayaz A · 2025
371
Herbal Medicines in Autism Spectrum Disorder: Therapeutic Potential, Plant Components, and Dosage Guidelines
Aldekhail NM, Khojah H, Alsaadoun NH, Al-Sanea MM, Alshammari SB, Alhazeemi AH et al. · 2025
372
Role of Anti-Inflammatory Diet and Fecal Microbiota Transplant in Psoriatic Arthritis
Gopalarathinam R, Sankar R, Zhao SS · 2024
373
Curcumin Formulations and Trials: What's New in Neurological Diseases
Gagliardi S, Morasso C, Stivaktakis P, Pandini C, Tinelli V, Tsatsakis A et al. · 2020

Every statement on this page carries its evidence tier — proven, plausible or hypothesis — and leads to the original work. The decision in the individual case rests with the practitioner; we provide the connections.