Fatigue and Stress

States of exhaustion are difficult to measure and are heavily influenced by the expectation effect. Controlled studies carry particular weight in this context.

1. Which Substances Have Been Investigated for This Purpose

The overview shows how many studies exist per substance and type of investigation. A single study may be assigned to multiple topics—therefore, the numbers are not additive but instead describe this specific subset.

2. All Substances and Therapies with Controlled Studies on Fatigue and Stress

123 substance and therapy pages assign controlled human studies to this area. The number comes from each page; one study can belong to several areas.

3. The Most Robust Studies

Ranked by evidential strength, not by popularity.

Controlled Human Study

• 1 "Effect of calcifediol treatment and best available therapy versus best available therapy on intensive care unit admission and mortality among patients (2020)"
• 2 Antioxidant and anti-inflammatory effects of curcuminoid-piperine combination in subjects with metabolic syndrome: A randomised controlled trial and an (2015)
• 3 A prospective, randomised, double-blind, placebo-controlled study of the safety and efficacy of a high-concentration, full-spectrum extract of ashwagandha root (2012)
• 4 Wisconsin Ginseng (Panax quinquefolius) to improve cancer-related fatigue: a randomised, double-blind trial, N07C2 (2013)
• 5 Curcumin supplementation improves vascular endothelial function in healthy middle-aged and older adults by increasing nitric oxide bioavailability and (2017)
• 6 Effects of phytosomal curcumin on anthropometric parameters, insulin resistance, cortisol levels and non-alcoholic fatty liver disease indices: a double-blind (2020)
• 7 Pilot study of Panax quinquefolius (American ginseng) to improve cancer-related fatigue: a randomised, double-blind, dose-finding evaluation: NCCTG trial (2010)
• 8 An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract: A randomised, double-blind, placebo-controlled (2019)
• 9 Vitamin D receptor stimulation to reduce acute respiratory distress syndrome (ARDS) in patients with coronavirus SARS-CoV-2 infections: Revised Ms SBM (2020)
• 10 Reduction of delayed onset muscle soreness by a novel curcumin delivery system (Meriva®): a randomised, placebo-controlled trial (2014)
• 11 Adaptogenic and Anxiolytic Effects of Ashwagandha Root Extract in Healthy Adults: A Double-blind, Randomised, Placebo-controlled Clinical Study (2019)
• 12 Vitamin D Supplementation Improves Cognitive Function Through Reducing Oxidative Stress Regulated by Telomere Length in Older Adults with Mild Cognitive (2020)
• 13 Body Weight Management in Adults Under Chronic Stress Through Treatment With Ashwagandha Root Extract: A Double-Blind, Randomised, Placebo-Controlled Trial (2017)
• 14 Calcifediol Treatment and Hospital Mortality Due to COVID-19: A Cohort Study (2021)
• 15 Safety and Clinical Effectiveness of Withania somnifera (Linn.) Dunal Root in Human Ailments (2020)
• 16 Efficacy and Safety of Ashwagandha (Withania somnifera) Root Extract in Insomnia and Anxiety: A Double-Blind, Randomised, Placebo-Controlled Study (2019)
• 17 Rhodiola rosea for Physical and Mental Fatigue: A Systematic Review (2012)
• 18 Vitamin D Supplementation in COVID-19 Patients: A Clinical Case Series (2020)
• 19 Rhodiola rosea L. as a Putative Botanical Antidepressant (2016)
• 20 A Randomised, Double-Blind, Placebo-Controlled, Crossover Study Examining the Hormonal and Vitality Effects of Ashwagandha (Withania somnifera) in Ageing Adults (2019)