The Interaction Network
Which compounds appear in the same human studies—whether as a combination, for comparison, or via a shared mechanism of action. Calculated from our proprietary study database, updated with each new harvest.
How the Network Is Formed
For every study involving humans and every review, we examine which other substances from the platform are featured in it. Two substances are connected if they appear in the same study. The strength of the connection is the number of such studies; the critical factor is the column for controlled studies—only there has a combination or comparison actually been tested.
A connection is not evidence of synergy. It shows where research has considered two substances together—and where it has not. The gaps in the network are as informative as the nodes: substances with similar mechanisms of action that have never been studied in combination.
The Strongest Connections
On each substance page, under "Interactions with other substances," the network excerpt for that substance is displayed, along with interactions with drugs and nutrients described in the literature.
Every statement on this page carries its evidence tier — proven, plausible or hypothesis — and leads to the original work. The decision in the individual case rests with the practitioner; we provide the connections.