Inflammatory Processes

Chronic low-grade inflammation is considered a common denominator in many clinical conditions. Accordingly, numerous natural substances are associated with it. This page shows what has actually been studied in humans.

1. Which Substances Have Been Investigated for This Purpose

The overview shows how many studies exist per substance and type of investigation. A single study may be assigned to multiple topics—therefore, the numbers cannot be added together but instead describe each respective subset.

2. All Substances and Therapies with Controlled Studies on Inflammatory Processes

108 substance and therapy pages assign controlled human studies to this area. The number comes from each page; one study can belong to several areas.

3. The Most Robust Studies

Ranked by evidential strength, not by popularity.

Controlled Human Study

• 1 Phase IIa clinical trial of curcumin for the prevention of colorectal neoplasia (2011)
• 2 Antioxidant and anti-inflammatory effects of curcuminoid-piperine combination in subjects with metabolic syndrome: A randomised controlled trial (2015)
• 3 Faecal microbiota transplantation with anti-inflammatory diet (FMT-AID) followed by anti-inflammatory diet alone is effective in inducing and maintaining remission in ulcerative colitis: A randomised controlled trial (2022)
• 4 Curcumin supplementation improves vascular endothelial function in healthy middle-aged and older adults by increasing nitric oxide bioavailability and reducing oxidative stress (2017)
• 5 Nano-curcumin improves glucose indices, lipids, inflammation, and nesfatin in overweight and obese patients with non-alcoholic fatty liver disease (NAFLD): A randomised, double-blind, placebo-controlled trial (2019)
• 6 Short-term effects of highly bioavailable curcumin for treating knee osteoarthritis: A randomised, double-blind, placebo-controlled prospective study (2014)
• 7 The spice for joint inflammation: Anti-inflammatory role of curcumin in treating osteoarthritis (2016)
• 8 Enriched marine oil supplements increase peripheral blood specialised pro-resolving mediator concentrations and reprogram host immune responses: A randomised controlled trial (2020)
• 9 Vitamin D receptor stimulation to reduce acute respiratory distress syndrome (ARDS) in patients with coronavirus SARS-CoV-2 infections: Revised manuscript SBMB (2020)
• 10 Clinical use of curcumin in depression: A meta-analysis (2017)
• 11 Oral curcumin with piperine as adjuvant therapy for the treatment of COVID-19: A randomised clinical trial (2021)
• 12 Modulation of exercise-induced muscle damage, inflammation, and oxidative markers by curcumin supplementation in a physically active population: A systematic review (2020)
• 13 Anti-Inflammatory Diet in Rheumatoid Arthritis (ADIRA)—A Randomised, Controlled Crossover Trial Indicating Effects on Disease Activity (2020)
• 14 Reduction of Delayed-Onset Muscle Soreness by a Novel Curcumin Delivery System (Meriva®): A Randomised, Placebo-Controlled Trial (2014)
• 15 Short-Term Curcuminoid Supplementation for Chronic Pulmonary Complications Due to Sulphur Mustard Intoxication: Positive Results of a Randomised Double-Blind Trial (2015)
• 16 Efficacy and Safety of Curcumin and <i>Curcuma longa</i> Extract in the Treatment of Arthritis: A Systematic Review and Meta-Analysis of Randomised Controlled Trials (2022)
• 17 Phytosome Complex of Curcumin as Complementary Therapy for Advanced Pancreatic Cancer Improves Safety and Efficacy of Gemcitabine: Results of a Prospective Study (2018)
• 18 The Influence of an Anti-Inflammatory Diet on Gingivitis: A Randomised Controlled Trial (2019)
• 19 Effect of Anti-Inflammatory Diets on Pain in Rheumatoid Arthritis: A Systematic Review and Meta-Analysis (2021)
• 20 Oral Curcumin (Meriva) Is Effective as an Adjuvant Treatment and Able to Reduce IL-22 Serum Levels in Patients with Psoriasis Vulgaris (2015)