Immune System

Few fields are as prone to sweeping statements as this one. It is therefore all the more important to distinguish between laboratory findings, animal studies, and actual human research.

1. Which Substances Have Been Investigated for This Purpose

The overview shows how many studies exist per substance and type of investigation. A single study may be assigned to multiple topics—therefore, the numbers cannot be added together but instead describe this specific subset.

2. All Substances and Therapies with Controlled Studies on Immune System

65 substance and therapy pages assign controlled human studies to this area. The number comes from each page; one study can belong to several areas.

3. The Most Robust Studies

Ranked by evidential strength, not by popularity.

Controlled Human Study

• 1 "Effect of calcifediol treatment and best available therapy versus best available therapy on intensive care unit admission and mortality among patients (2020)"
• 2 Phase IIa clinical trial of curcumin for the prevention of colorectal neoplasia (2011)
• 3 Vitamin D for the Prevention of Disease: An Endocrine Society Clinical Practice Guideline (2024)
• 4 Can supplementation with vitamin D reduce the risk or modify the course of autoimmune diseases? A systematic review of the literature (2012)
• 5 Enriched Marine Oil Supplements Increase Peripheral Blood Specialized Pro-Resolving Mediators Concentrations and Reprogram Host Immune Responses: A Randomised Controlled Trial (2020)
• 6 Vitamin D receptor stimulation to reduce acute respiratory distress syndrome (ARDS) in patients with coronavirus SARS-CoV-2 infections: Revised Ms SBM (2020)
• 7 Oral Curcumin (Meriva) Is Effective as an Adjuvant Treatment and Is Able to Reduce IL-22 Serum Levels in Patients with Psoriasis Vulgaris (2015)
• 8 Treatment With 25-Hydroxyvitamin D₃ (Calcifediol) Is Associated With a Reduction in the Blood Neutrophil-to-Lymphocyte Ratio Marker of Disease (2021)
• 9 Safety and clinical effectiveness of Withania somnifera (Linn.) Dunal root in human ailments (2020)
• 10 Vitamin D Supplementation in COVID-19 Patients: A Clinical Case Series (2020)
• 11 Rhodiola rosea L. as a putative botanical antidepressant (2016)
• 12 Double-blinded randomised controlled trial for immunomodulatory effects of Tulsi (Ocimum sanctum Linn.) leaf extract on healthy volunteers (2011)
• 13 Stimulating the Resolution of Inflammation Through Omega-3 Polyunsaturated Fatty Acids in COVID-19: Rationale for the COVID-Omega-F Trial (2020)
• 14 Curcumin and Curcuma longa Extract in the Treatment of 10 Types of Autoimmune Diseases: A Systematic Review and Meta-Analysis of 31 Randomised Controlled Trials (2022)
• 15 Low vitamin D levels do not exacerbate COVID-19 risk or mortality, and vitamin D supplementation does not improve outcomes in hospitalised patients with COVID-19 (2021)
• 16 Adjunctive Use of a Standardised Extract of Withania somnifera (Ashwagandha) to Treat Symptom Exacerbation in Schizophrenia: A Randomised, Double-Blind, Placebo-Controlled Trial (2018)
• 17 Efficacy of an Oral Nano-Curcumin Formulation in the Management of Mild to Moderate Outpatient COVID-19: A Randomised, Triple-Blind, Placebo-Controlled Clinical Trial (2021)
• 18 Randomised, Placebo-Controlled Pilot Clinical Trial on the Efficacy of an Ayurvedic Treatment Regimen in COVID-19 Positive Patients (2021)
• 19 Ergocalciferol Supplementation in Haemodialysis Patients With Vitamin D Deficiency: A Randomised Clinical Trial (2016)
• 20 Efficacy of Ashwagandha (Withania somnifera [L.] Dunal) in Improving Cardiorespiratory Endurance in Healthy Athletic Adults (2015)