Glycine and Ageing: What David Sinclair Discusses in His Podcast
The episode asks whether glycine plays a role in ageing — one of the simplest amino acids, sweet enough to replace sugar, and also found on asteroids and comets. It covers collagen, blood sugar, heart, memory and recovery after stroke, as well as work linking glycine to longer lifespans in animal models, and closes with the question of what it would take to show such effects in humans.
With David Sinclair, Professor of Genetics, Harvard Medical School. Declared interests: Founder and shareholder of several companies for dietary supplements and ageing medicine (including Animal Bioscience, Tally Health, Metro Biotech). Sponsors of this episode: Ketone-IQ, WHOOP, Withings; Matthew LaPlante, science journalist.
▶ This Sugar Substitute May Extend Your Life | Lifespan with Dr. David Sinclair - S2, Ep. 9 — David Sinclair, YouTube, 2026-09-20
The source’s view, not our assessment — whether it holds up is for research to show. Evidence on Glycine.
How It Fits Earlier Research
The earlier review on glycine and ageing describes lifespan benefits in animal models — precisely the animal findings the podcast takes as its starting point. Whether such effects can be shown in humans remains the open question both raise. Glycine and aging: Evidence and mechanisms. (2023)
Every statement on this page carries its evidence tier — proven, plausible or hypothesis — and leads to the original work. The decision in the individual case rests with the practitioner; we provide the connections.