Systematic Review with Meta-Analysis of Randomized Controlled Trials: Gut Microbiota-Targeted Approaches in Osteoarthritis – Symptomatic Benefit
A systematic review and meta-analysis of randomized controlled trials evaluated probiotics, prebiotics, synbiotics, or dietary modification for pain, physical function, and inflammatory biomarkers in osteoarthritis. Probiotics may improve pain, physical function, and systemic inflammation.
1. What the Research Says
Databases were searched up to January 2026; GRADE certainty ranged from high (WOMAC function) to very low (VAS pain). Unchanged COMP indicates no support for cartilage protection or disease modification.
2. First Review on This Question
This is the first review on this question: it pools the existing individual studies, and there is no earlier review on it. Its result still needs to be confirmed by further studies.
3. Source
Full evidence overview: Probiotics
Every statement on this page carries its evidence tier — proven, plausible or hypothesis — and leads to the original work. The decision in the individual case rests with the practitioner; we provide the connections.